YRC Public Data Repository - Protein Structure Prediction

Protein:	FRDA_ECOLI
Organism:	Escherichia coli
Length:	602 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRDA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|151937207, gi... - gi\|75854923\|ref\|ZP_00762591.1\| COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein sub...	507.0	[0..1]	[582..1]
gi\|59712941, gi\|... - gi\|59712941\|ref\|YP_205717.1\| fumarate reductase flavoprotein subunit [Vibrio fischeri ES114], gi\|594...	507.0	[0..1]	[582..1]
gi\|28807866, gi\|... - gi\|28899614\|ref\|NP_799219.1\| fumarate reductase flavoprotein subunit [Vibrio parahaemolyticus RIMD 2... gi\|28807866 - gi\|28807866\|dbj\|BAC61103.1\| fumarate reductase, flavoprotein subunit [Vibrio parahaemolyticus RIMD 2... gi\|153838019, gi... - gi\|153838019\|ref\|ZP_01990686.1\| fumarate reductase, flavoprotein subunit [Vibrio parahaemolyticus AQ...	506.0	[0..1]	[582..1]
gi\|91228402, gi\|... - gi\|91228402\|ref\|ZP_01262328.1\| fumarate reductase [Vibrio alginolyticus 12G01], gi\|91188043\|gb\|EAS74...	505.0	[0..1]	[582..1]
gi\|84378250, gi\|... - gi\|84386960\|ref\|ZP_00989984.1\| fumarate reductase [Vibrio splendidus 12B01], gi\|84378250\|gb\|EAP95109...	503.0	[0..1]	[582..1]
gi\|27364670, gi\|... - gi\|27364670\|ref\|NP_760198.1\| fumarate reductase flavoprotein subunit [Vibrio vulnificus CMCP6], gi\|2...	503.0	[0..1]	[582..1]
gi\|86147218, gi\|... - gi\|86147218\|ref\|ZP_01065533.1\| fumarate reductase [Vibrio sp. MED222], gi\|85834933\|gb\|EAQ53076.1\| fu...	502.0	[0..1]	[582..1]
gi\|150421241, gi... - gi\|75823999\|ref\|ZP_00753469.1\| COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein sub... gi\|229349453, gi... - gi\|229513576\|ref\|ZP_04403040.1\| succinate dehydrogenase flavoprotein subunit [Vibrio cholerae TMA 21... gi\|229527419, gi... - gi\|229527419\|ref\|ZP_04416811.1\| succinate dehydrogenase flavoprotein subunit [Vibrio cholerae 12129(... gi\|229341313, gi... - gi\|229521719\|ref\|ZP_04411137.1\| succinate dehydrogenase flavoprotein subunit [Vibrio cholerae TM 110... tr\|A0A085SCH7\|A0... - Fumarate reductase, flavoprotein subunit OS=Vibrio cholerae GN=frdA PE=4 SV=1 gi\|124115566, gi... - gi\|153213996\|ref\|ZP_01949189.1\| fumarate reductase, flavoprotein subunit [Vibrio cholerae 1587], gi\|... gi\|149741232, gi... - gi\|153825086\|ref\|ZP_01977753.1\| fumarate reductase, flavoprotein subunit [Vibrio cholerae MZO-2], gi...	498.0	[0..1]	[581..1]
gi\|194537417, gi... - gi\|75819842\|ref\|ZP_00749905.1\| COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein sub...	498.0	[0..1]	[581..1]
gi\|229606801, gi... - gi\|229606801\|ref\|YP_002877449.1\| succinate dehydrogenase flavoprotein subunit [Vibrio cholerae MJ-12... gi\|197752605, gi... - gi\|254285848\|ref\|ZP_04960810.1\| fumarate reductase, flavoprotein subunit [Vibrio cholerae AM-19226],... gi\|153829468, gi... - gi\|153829468\|ref\|ZP_01982135.1\| fumarate reductase, flavoprotein subunit [Vibrio cholerae 623-39], g... gi\|75830072, gi\|... - gi\|75830072\|ref\|ZP_00759357.1\| COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein sub... gi\|227014544, gi... - gi\|75827902\|ref\|ZP_00757337.1\| COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein sub... gi\|121727580, gi... - gi\|75816581\|ref\|ZP_00747047.1\| COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein sub... gi\|124119922, gi... - gi\|153221011\|ref\|ZP_01952066.1\| fumarate reductase, flavoprotein subunit [Vibrio cholerae MAK 757], ... gi\|153819795, gi... - gi\|153819795\|ref\|ZP_01972462.1\| fumarate reductase, flavoprotein subunit [Vibrio cholerae NCTC 8457]... gi\|126520938, gi... - gi\|229509781\|ref\|ZP_04399262.1\| succinate dehydrogenase flavoprotein subunit [Vibrio cholerae B33], ... gi\|227010660, gi... - gi\|227082772\|ref\|YP_002811323.1\| fumarate reductase, flavoprotein subunit [Vibrio cholerae M66-2], g... gi\|9657248, gi\|1... - gi\|9657248\|gb\|AAF95797.1\| fumarate reductase, flavoprotein subunit [Vibrio cholerae O1 biovar El Tor... gi\|229507295, gi... - gi\|229507295\|ref\|ZP_04396800.1\| succinate dehydrogenase flavoprotein subunit [Vibrio cholerae BX 330... gi\|11252516 - pir\|\|F82050 fumarate reductase, flavoprotein chain VC2656 [imported] - Vibrio cholerae (strain N1696... gi\|229345969, gi... - gi\|229516906\|ref\|ZP_04406352.1\| succinate dehydrogenase flavoprotein subunit [Vibrio cholerae RC9], ...	497.0	[0..1]	[581..1]

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Predicted Domain #1

Region A:
Residues: [1-602]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTFQADLAI VGAGGAGLRA AIAAAQANPN AKIALISKVY PMRSHTVAAE GGSAAVAQDH  60
   61 DSFEYHFHDT VAGGDWLCEQ DVVDYFVHHC PTEMTQLELW GCPWSRRPDG SVNVRRFGGM 120
  121 KIERTWFAAD KTGFHMLHTL FQTSLQFPQI QRFDEHFVLD ILVDDGHVRG LVAMNMMEGT 180
  181 LVQIRANAVV MATGGAGRVY RYNTNGGIVT GDGMGMALSH GVPLRDMEFV QYHPTGLPGS 240
  241 GILMTEGCRG EGGILVNKNG YRYLQDYGMG PETPLGEPKN KYMELGPRDK VSQAFWHEWR 300
  301 KGNTISTPRG DVVYLDLRHL GEKKLHERLP FICELAKAYV GVDPVKEPIP VRPTAHYTMG 360
  361 GIETDQNCET RIKGLFAVGE CSSVGLHGAN RLGSNSLAEL VVFGRLAGEQ ATERAATAGN 420
  421 GNEAAIEAQA AGVEQRLKDL VNQDGGENWA KIRDEMGLAM EEGCGIYRTP ELMQKTIDKL 480
  481 AELQERFKRV RITDTSSVFN TDLLYTIELG HGLNVAECMA HSAMARKESR GAHQRLDEGC 540
  541 TERDDVNFLK HTLAFRDADG TTRLEYSDVK ITTLPPAKRV YGGEADAADK AEAANKKEKA 600
  601 NG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	135.0
Match:	2b76A
Description:	E. coli Quinol fumarate reductase FrdA E49Q mutation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
succinate dehydrogenase activity	10.1697547809338	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	8.87698547678677	bayes_pls_golite062009
succinate dehydrogenase (ubiquinone) activity	8.87698547678677	bayes_pls_golite062009
L-aspartate oxidase activity	7.97437641217089	bayes_pls_golite062009
aspartate oxidase activity	7.32727957948448	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	6.81299528298802	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	5.74880353813045	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	5.00880700655468	bayes_pls_golite062009
oxidoreductase activity	4.62076392207627	bayes_pls_golite062009
NADPH-adrenodoxin reductase activity	3.86336671540719	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.57282017498189	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.50603438449246	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.28982462439281	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	2.26549080531565	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	2.16428165652808	bayes_pls_golite062009
electron carrier activity	1.96249176032145	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	1.91979117253135	bayes_pls_golite062009
binding	1.343461862937	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.18990628739838	bayes_pls_golite062009
antioxidant activity	1.12347155061135	bayes_pls_golite062009
catalytic activity	1.02941336036162	bayes_pls_golite062009
transporter activity	0.890824576391732	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	0.798505263716232	bayes_pls_golite062009
transmembrane transporter activity	0.706117386114413	bayes_pls_golite062009
ferredoxin reductase activity	0.61713057030514	bayes_pls_golite062009
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	0.61713057030514	bayes_pls_golite062009
ferredoxin-NADP+ reductase activity	0.61713057030514	bayes_pls_golite062009
FAD binding	0.525342258522943	bayes_pls_golite062009
substrate-specific transporter activity	0.491481205015383	bayes_pls_golite062009
coenzyme binding	0.48211536331404	bayes_pls_golite062009
succinate-CoA ligase activity	0.468246082354334	bayes_pls_golite062009
protein binding	0.404450175883241	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.26114823844682	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: