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View Structure Prediction Details

Protein: gi|190689293, gi...
Organism: synthetic construct
Length: 393 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190689293, gi....

Description E-value Query
Range
Subject
Range
gi|114603719, gi... - gi|55625514|ref|XP_518140.1| PREDICTED: hypothetical protein XP_518140 [Pan troglodytes], gi|1146037...
0.0 [1..393] [1..393]
gi|109079984, gi... - gi|109079988|ref|XP_001095477.1| PREDICTED: similar to CG3295-PA isoform 12 [Macaca mulatta], gi|109...
0.0 [1..393] [1..393]
gi|62945302, gi|... - gi|62945302|ref|NP_001017473.1| required for meiotic nuclear division 5 homolog B [Rattus norvegicus...
0.0 [1..393] [1..393]
RMD5B_MOUSE - Protein RMD5 homolog B OS=Mus musculus GN=Rmnd5b PE=2 SV=1
0.0 [1..393] [1..393]
gi|73970525 - gi|73970525|ref|XP_531873.2| PREDICTED: similar to CG3295-PA [Canis familiaris]
0.0 [1..393] [1..393]
gi|76622625, gi|... - gi|76622625|ref|XP_888435.1| PREDICTED: similar to CG3295-PA isoform 10 [Bos taurus], gi|76622609|re...
0.0 [1..393] [1..393]
gi|10434433 - gi|10434433|dbj|BAB14257.1| unnamed protein product [Homo sapiens]
0.0 [1..393] [1..391]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQCACVERE LDKVLQKFLT YGQHCERSLE ELLHYVGQLR AELASAALQG TPLSATLSLV  60
   61 MSQCCRKIKD TVQKLASDHK DIHSSVSRVG KAIDRNFDSE ICGVVSDAVW DAREQQQQIL 120
  121 QMAIVEHLYQ QGMLSVAEEL CQESTLNVDL 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.968 N/A N/A a.24.9 alpha-catenin/vinculin

Predicted Domain #2
Region A:
Residues: [151-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFKQPFLELN RILEALHEQD LGPALEWAVS HRQRLLELNS SLEFKLHRLH FIRLLAGGPA  60
   61 KQLEALSYAR HFQPFARLHQ REIQVMMGSL VYLRLGLEKS PYCHLLDSSH WAEICETFTR 120
  121 DACSLLGLSV ESPLSVSFAS GCVALPVLMN IKAVIEQRQC TGVWNHKDEL PIEIELGMKC 180
  181 WYHSVFACPI LRQQTSDSNP PIKLICGHVI SRDALNKLIN GGKLKCPYCP MEQNPADGKR 240
  241 IIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1fbvA
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.12724619324809 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.53071837898279 bayes_pls_golite062009
small conjugating protein ligase activity 2.35007226898734 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
transcription regulator activity 1.79278689121507 bayes_pls_golite062009
acid-amino acid ligase activity 1.60687631865164 bayes_pls_golite062009
nucleic acid binding 1.59077352153329 bayes_pls_golite062009
DNA binding 1.49540318847431 bayes_pls_golite062009
transcription repressor activity 0.937092252245555 bayes_pls_golite062009
transcription factor activity 0.862300124095671 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.748479359639348 bayes_pls_golite062009
kinase activity 0.662911740280035 bayes_pls_golite062009
molecular adaptor activity 0.657981592359252 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.559549509453052 bayes_pls_golite062009
phosphoprotein binding 0.53553338374323 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.493362981045534 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.452350351194157 bayes_pls_golite062009
protein phosphorylated amino acid binding 0.43808715710519 bayes_pls_golite062009
protein kinase activity 0.373245013550244 bayes_pls_golite062009
protein binding, bridging 0.370788151516215 bayes_pls_golite062009
transferase activity 0.169970258787201 bayes_pls_golite062009
signal transducer activity 0.150891693412241 bayes_pls_golite062009
molecular transducer activity 0.150891693412241 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle