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View Protein Complex Details

Complex Overview

From Publication: Qiu J, Noble WS (2008) Predicting Co-Complexed Protein Pairs from Heterogeneous Data. PLoS Comput Biol 4(4): e1000054. doi:10.1371/journal.pcbi.1000054
Notes: Classfier did not use Gene Ontology annotations. [FDR: 0.021] [SVM Score: 0.849584955566]
Complex Size: 2 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
    		•
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
    		•
  • DNA binding
    		•
    HHT1, HHT2
  • nucleus
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • nucleosome
    		•
  • mitotic cell cycle spindle assembly checkpoint
  • DNA repair
  • negative regulation of biosynthetic process
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • response to DNA damage stimulus
  • aging
  • DNA packaging
  • nucleosome assembly
  • negative regulation of transposition, RNA-mediated
  • chromosome organization
  • negative regulation of transcription
  • negative regulation of transposition
  • regulation of transposition
  • regulation of transposition, RNA-mediated
    		•
  • DNA binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    replication fork protection complex 5.0527E-8 2 2 2 6292
    nuclear nucleosome 3.3348E-6 2 12 2 6292
    nucleosome 3.3348E-6 2 12 2 6292
    nuclear replication fork 9.6001E-6 2 20 2 6292
    replication fork 4.3504E-5 2 42 2 6292
    protein-DNA complex 8.0641E-5 2 57 2 6292
    nuclear chromatin 1.3278E-4 2 73 2 6292
    chromatin 1.4784E-4 2 77 2 6292
    nuclear chromosome part 9.0721E-4 2 190 2 6292
    nuclear chromosome 1.3075E-3 2 228 2 6292
    chromosomal part 1.413E-3 2 237 2 6292
    chromosome 1.8898E-3 2 274 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nucleosome assembly 6.0632E-6 2 16 2 6292
    chromatin assembly 8.6401E-6 2 19 2 6292
    nucleosome organization 2.0514E-5 2 29 2 6292
    DNA packaging 2.5061E-5 2 32 2 6292
    chromatin assembly or disassembly 3.0063E-5 2 35 2 6292
    protein-DNA complex assembly 3.744E-5 2 39 2 6292
    DNA conformation change 8.3521E-5 2 58 2 6292
    positive regulation of transcription 3.1407E-4 2 112 2 6292
    positive regulation of gene expression 3.1407E-4 2 112 2 6292
    histone H3-K79 methylation 3.1786E-4 2 1 1 6292
    negative regulation of transposition, RNA-mediated 3.1786E-4 2 1 1 6292
    regulation of transposition, RNA-mediated 3.1786E-4 2 1 1 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.4879E-4 2 118 2 6292
    positive regulation of nitrogen compound metabolic process 3.4879E-4 2 118 2 6292
    positive regulation of macromolecule biosynthetic process 3.4879E-4 2 118 2 6292
    positive regulation of biosynthetic process 3.6682E-4 2 121 2 6292
    positive regulation of cellular biosynthetic process 3.6682E-4 2 121 2 6292
    positive regulation of macromolecule metabolic process 3.979E-4 2 126 2 6292
    positive regulation of metabolic process 4.1715E-4 2 129 2 6292
    positive regulation of cellular metabolic process 4.1715E-4 2 129 2 6292
    positive regulation of cellular process 4.6384E-4 2 136 2 6292
    positive regulation of biological process 4.7071E-4 2 137 2 6292
    histone lysine methylation 6.3568E-4 2 2 1 6292
    negative regulation of transcription 6.7534E-4 2 164 2 6292
    negative regulation of gene expression 6.7534E-4 2 164 2 6292
    negative regulation of macromolecule biosynthetic process 7.6927E-4 2 175 2 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.1399E-4 2 180 2 6292
    negative regulation of nitrogen compound metabolic process 8.1399E-4 2 180 2 6292
    cellular macromolecular complex assembly 8.3223E-4 2 182 2 6292
    negative regulation of biosynthetic process 8.9766E-4 2 189 2 6292
    negative regulation of cellular biosynthetic process 8.9766E-4 2 189 2 6292
    DNA repair 9.2646E-4 2 192 2 6292
    negative regulation of macromolecule metabolic process 9.2646E-4 2 192 2 6292
    chromatin organization 1.036E-3 2 203 2 6292
    negative regulation of cellular metabolic process 1.0983E-3 2 209 2 6292
    negative regulation of metabolic process 1.1088E-3 2 210 2 6292
    response to DNA damage stimulus 1.4011E-3 2 236 2 6292
    negative regulation of cellular process 1.5726E-3 2 250 2 6292
    negative regulation of biological process 1.6107E-3 2 253 2 6292
    cellular macromolecular complex subunit organization 1.6882E-3 2 259 2 6292
    macromolecular complex assembly 1.9877E-3 2 281 2 6292
    cellular response to stress 2.1173E-3 2 290 2 6292
    negative regulation of transposition 2.859E-3 2 9 1 6292
    regulation of transposition 2.859E-3 2 9 1 6292
    macromolecular complex subunit organization 3.2108E-3 2 357 2 6292
    cellular response to stimulus 3.6193E-3 2 379 2 6292
    regulation of transcription 3.7155E-3 2 384 2 6292
    cellular component assembly 3.7349E-3 2 385 2 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.3405E-3 2 415 2 6292
    regulation of nitrogen compound metabolic process 4.3615E-3 2 416 2 6292
    regulation of gene expression 4.9915E-3 2 445 2 6292
    regulation of macromolecule biosynthetic process 5.2416E-3 2 456 2 6292
    regulation of cellular biosynthetic process 5.6164E-3 2 472 2 6292
    regulation of biosynthetic process 5.6402E-3 2 473 2 6292
    regulation of macromolecule metabolic process 6.004E-3 2 488 2 6292
    response to stress 6.2277E-3 2 497 2 6292
    histone methylation 6.3477E-3 2 20 1 6292
    regulation of primary metabolic process 6.6615E-3 2 514 2 6292
    mitotic cell cycle spindle assembly checkpoint 6.6645E-3 2 21 1 6292
    negative regulation of nuclear division 6.6645E-3 2 21 1 6292
    negative regulation of mitosis 6.6645E-3 2 21 1 6292
    negative regulation of mitotic metaphase/anaphase transition 6.6645E-3 2 21 1 6292
    spindle assembly checkpoint 6.6645E-3 2 21 1 6292
    negative regulation of cell cycle 6.9813E-3 2 22 1 6292
    regulation of cellular metabolic process 7.2445E-3 2 536 2 6292
    regulation of metabolic process 7.5452E-3 2 547 2 6292
    protein amino acid alkylation 7.6148E-3 2 24 1 6292
    protein amino acid methylation 7.6148E-3 2 24 1 6292
    transcription 7.6839E-3 2 552 2 6292
    chromosome organization 7.7677E-3 2 555 2 6292
    spindle checkpoint 7.9314E-3 2 25 1 6292
    regulation of mitotic metaphase/anaphase transition 7.9314E-3 2 25 1 6292
    mitotic cell cycle spindle checkpoint 7.9314E-3 2 25 1 6292
    DNA metabolic process 8.631E-3 2 585 2 6292
    mitotic cell cycle checkpoint 8.8811E-3 2 28 1 6292
    negative regulation of cellular component organization 9.1975E-3 2 29 1 6292
    regulation of nuclear division 9.1975E-3 2 29 1 6292
    negative regulation of organelle organization 9.1975E-3 2 29 1 6292
    regulation of mitosis 9.1975E-3 2 29 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    DNA binding 1.6492E-3 2 256 2 6292
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