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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Gcn3. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BGL2
  • fungal-type cell wall
  • cellular cell wall organization
  • glucan 1,3-beta-glucosidase activity
  • CBP6
  • mitochondrion
  • translation
  • molecular_function
  • FRS2
  • cytoplasm
  • phenylalanine-tRNA ligase complex
  • phenylalanyl-tRNA aminoacylation
  • phenylalanine-tRNA ligase activity
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • GCN3
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • HXT7
  • mitochondrion
  • plasma membrane
  • hexose transport
  • fructose transmembrane transporter activity
  • glucose transmembrane transporter activity
  • mannose transmembrane transporter activity
  • MCX1
  • mitochondrial matrix
  • mitochondrion
  • biological_process
  • ATP binding
  • unfolded protein binding
  • NDE1
  • mitochondrion
  • NADH oxidation
  • glucose catabolic process to ethanol
  • chronological cell aging
  • NADH dehydrogenase activity
  • NPA3
  • cytoplasm
  • biological_process
  • ATPase activity
  • PET10
  • lipid particle
  • aerobic respiration
  • molecular_function
  • PET9
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • mitochondrial transport
  • aerobic respiration
  • ATP transport
  • ADP transport
  • ATP:ADP antiporter activity
  • SLC1
  • lipid particle
  • sphingolipid biosynthetic process
  • 1-acylglycerol-3-phosphate O-acyltransferase activity
  • TRP3
  • cytoplasm
  • anthranilate synthase complex
  • tryptophan biosynthetic process
  • indole-3-glycerol-phosphate synthase activity
  • anthranilate synthase activity
  • TRP5
  • nucleus
  • cytoplasm
  • tryptophan biosynthetic process
  • tryptophan synthase activity
  • VPS8
  • membrane fraction
  • late endosome to vacuole transport
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    lipid particle 3.0164E-3 15 35 2 6292
    anthranilate synthase complex 4.7627E-3 15 2 1 6292
    phenylalanine-tRNA ligase complex 4.7627E-3 15 2 1 6292
    eukaryotic translation initiation factor 2 complex 7.136E-3 15 3 1 6292
    cytoplasmic part 8.2094E-3 15 2482 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    indolalkylamine biosynthetic process 3.4536E-4 15 12 2 6292
    tryptophan metabolic process 3.4536E-4 15 12 2 6292
    indole and derivative metabolic process 3.4536E-4 15 12 2 6292
    indole derivative metabolic process 3.4536E-4 15 12 2 6292
    indole derivative biosynthetic process 3.4536E-4 15 12 2 6292
    tryptophan biosynthetic process 3.4536E-4 15 12 2 6292
    indolalkylamine metabolic process 3.4536E-4 15 12 2 6292
    aromatic amino acid family biosynthetic process 7.9401E-4 15 18 2 6292
    chorismate metabolic process 7.9401E-4 15 18 2 6292
    cellular biogenic amine biosynthetic process 9.8331E-4 15 20 2 6292
    aromatic amino acid family metabolic process 1.4205E-3 15 24 2 6292
    cellular amino acid derivative biosynthetic process 1.9348E-3 15 28 2 6292
    dicarboxylic acid metabolic process 2.2205E-3 15 30 2 6292
    ADP transport 2.384E-3 15 1 1 6292
    cellular biogenic amine metabolic process 3.367E-3 15 37 2 6292
    aromatic compound biosynthetic process 3.9271E-3 15 40 2 6292
    translational initiation 4.323E-3 15 42 2 6292
    phenylalanyl-tRNA aminoacylation 4.7627E-3 15 2 1 6292
    anaerobic respiration 4.7627E-3 15 2 1 6292
    energy derivation by oxidation of organic compounds 4.8042E-3 15 149 3 6292
    purine ribonucleotide transport 7.136E-3 15 3 1 6292
    ATP transport 7.136E-3 15 3 1 6292
    adenine nucleotide transport 7.136E-3 15 3 1 6292
    cellular amino acid derivative metabolic process 8.9514E-3 15 61 2 6292
    purine nucleotide transport 9.5041E-3 15 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation initiation factor activity 1.7991E-3 15 27 2 6292
    1-acylglycerol-3-phosphate O-acyltransferase activity 2.384E-3 15 1 1 6292
    indole-3-glycerol-phosphate synthase activity 2.384E-3 15 1 1 6292
    tryptophan synthase activity 2.384E-3 15 1 1 6292
    translation factor activity, nucleic acid binding 4.7368E-3 15 44 2 6292
    acylglycerol O-acyltransferase activity 4.7627E-3 15 2 1 6292
    anthranilate synthase activity 4.7627E-3 15 2 1 6292
    ATP:ADP antiporter activity 7.136E-3 15 3 1 6292
    NADH dehydrogenase activity 7.136E-3 15 3 1 6292
    oxo-acid-lyase activity 9.5041E-3 15 4 1 6292
    phenylalanine-tRNA ligase activity 9.5041E-3 15 4 1 6292

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