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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ume1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 4 proteins

Complex Member Proteins

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term

P-value

A

B

I

T

histone deacetylase complex 7.6359E-5 4 23 2 6292
chromatin remodeling complex 1.4406E-3 4 99 2 6292
Sin3 complex 2.5411E-3 4 4 1 6292
Sin3-type complex 3.1756E-3 4 5 1 6292
nucleoplasm part 8.6014E-3 4 245 2 6292
nucleoplasm 9.9491E-3 4 264 2 6292

Biological Process Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term

P-value

A

B

I

T

histone deacetylation 2.69E-10 4 27 4 6292
protein amino acid deacetylation 3.6404E-10 4 29 4 6292
covalent chromatin modification 3.5742E-8 4 88 4 6292
histone modification 3.5742E-8 4 88 4 6292
chromatin modification 4.9077E-7 4 168 4 6292
chromatin organization 1.0528E-6 4 203 4 6292
post-translational protein modification 1.02E-5 4 357 4 6292
positive regulation of transcription 2.1685E-5 4 112 3 6292
positive regulation of gene expression 2.1685E-5 4 112 3 6292
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.5376E-5 4 118 3 6292
positive regulation of nitrogen compound metabolic process 2.5376E-5 4 118 3 6292
positive regulation of macromolecule biosynthetic process 2.5376E-5 4 118 3 6292
positive regulation of biosynthetic process 2.7369E-5 4 121 3 6292
positive regulation of cellular biosynthetic process 2.7369E-5 4 121 3 6292
positive regulation of macromolecule metabolic process 3.0916E-5 4 126 3 6292
positive regulation of metabolic process 3.3184E-5 4 129 3 6292
positive regulation of cellular metabolic process 3.3184E-5 4 129 3 6292
positive regulation of cellular process 3.8899E-5 4 136 3 6292
protein modification process 3.9123E-5 4 499 4 6292
positive regulation of biological process 3.9765E-5 4 137 3 6292
chromatin silencing at rDNA 4.6226E-5 4 18 2 6292
chromosome organization 5.9941E-5 4 555 4 6292
macromolecule modification 6.624E-5 4 569 4 6292
double-strand break repair via nonhomologous end joining 9.0505E-5 4 25 2 6292
chromatin silencing at silent mating-type cassette 1.5902E-4 4 33 2 6292
non-recombinational repair 1.6892E-4 4 34 2 6292
regulation of cellular process 2.5447E-4 4 796 4 6292
regulation of biological process 2.9228E-4 4 824 4 6292
chromatin silencing at telomere 4.4515E-4 4 55 2 6292
double-strand break repair 4.7822E-4 4 57 2 6292
negative regulation of transcription from RNA polymerase II promoter 5.3002E-4 4 60 2 6292
cellular protein metabolic process 8.4498E-4 4 1074 4 6292
regulation of transcription 8.6159E-4 4 384 3 6292
organelle organization 1.0248E-3 4 1127 4 6292
positive regulation of transcription from RNA polymerase II promoter 1.0385E-3 4 84 2 6292
protein metabolic process 1.058E-3 4 1136 4 6292
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.084E-3 4 415 3 6292
regulation of nitrogen compound metabolic process 1.0917E-3 4 416 3 6292
regulation of gene expression 1.3321E-3 4 445 3 6292
biological regulation 1.3758E-3 4 1213 4 6292
regulation of macromolecule biosynthetic process 1.4316E-3 4 456 3 6292
negative regulation of gene expression, epigenetic 1.4697E-3 4 100 2 6292
gene silencing 1.4697E-3 4 100 2 6292
regulation of gene expression, epigenetic 1.4697E-3 4 100 2 6292
chromatin silencing 1.4697E-3 4 100 2 6292
positive regulation of transcription, DNA-dependent 1.5586E-3 4 103 2 6292
regulation of cellular biosynthetic process 1.5848E-3 4 472 3 6292
regulation of biosynthetic process 1.5947E-3 4 473 3 6292
positive regulation of RNA metabolic process 1.6812E-3 4 107 2 6292
regulation of macromolecule metabolic process 1.7483E-3 4 488 3 6292
regulation of primary metabolic process 2.0368E-3 4 514 3 6292
regulation of cellular metabolic process 2.3038E-3 4 536 3 6292
regulation of metabolic process 2.4454E-3 4 547 3 6292
transcription 2.5116E-3 4 552 3 6292
negative regulation of transcription, DNA-dependent 3.5916E-3 4 157 2 6292
negative regulation of RNA metabolic process 3.6369E-3 4 158 2 6292
negative regulation of transcription 3.9142E-3 4 164 2 6292
negative regulation of gene expression 3.9142E-3 4 164 2 6292
cellular component organization 3.9851E-3 4 1582 4 6292
negative regulation of macromolecule biosynthetic process 4.4481E-3 4 175 2 6292
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.7016E-3 4 180 2 6292
negative regulation of nitrogen compound metabolic process 4.7016E-3 4 180 2 6292
negative regulation of biosynthetic process 5.1748E-3 4 189 2 6292
negative regulation of cellular biosynthetic process 5.1748E-3 4 189 2 6292
DNA repair 5.3374E-3 4 192 2 6292
negative regulation of macromolecule metabolic process 5.3374E-3 4 192 2 6292
loss of chromatin silencing involved in replicative cell aging 5.7106E-3 4 9 1 6292
negative regulation of cellular metabolic process 6.3039E-3 4 209 2 6292
progressive alteration of chromatin involved in replicative cell aging 6.3436E-3 4 10 1 6292
loss of chromatin silencing 6.3436E-3 4 10 1 6292
negative regulation of metabolic process 6.3631E-3 4 210 2 6292
progressive alteration of chromatin involved in cell aging 6.9763E-3 4 11 1 6292
positive regulation of gene expression, epigenetic 6.9763E-3 4 11 1 6292
regulation of gene silencing 6.9763E-3 4 11 1 6292
negative regulation of gene silencing 6.9763E-3 4 11 1 6292
regulation of chromatin silencing 6.9763E-3 4 11 1 6292
negative regulation of chromatin silencing 6.9763E-3 4 11 1 6292
regulation of transcription from RNA polymerase II promoter 7.4744E-3 4 228 2 6292
response to DNA damage stimulus 7.9954E-3 4 236 2 6292
negative regulation of cellular process 8.9471E-3 4 250 2 6292
negative regulation of biological process 9.1576E-3 4 253 2 6292

Molecular Function Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term

P-value

A

B

I

T

histone deacetylase activity 5.5118E-10 4 32 4 6292
protein deacetylase activity 5.5118E-10 4 32 4 6292
deacetylase activity 8.0255E-10 4 35 4 6292
transcription factor binding 1.8916E-9 4 43 4 6292
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.9824E-9 4 48 4 6292
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2.4242E-8 4 80 4 6292
transcription corepressor activity 5.3897E-8 4 16 3 6292
transcription cofactor activity 9.4818E-7 4 40 3 6292
transcription repressor activity 1.2704E-6 4 44 3 6292
transcription coactivator activity 6.3408E-5 4 21 2 6292
protein binding 8.8715E-5 4 612 4 6292
hydrolase activity 4.3699E-4 4 911 4 6292
transcription activator activity 5.4787E-4 4 61 2 6292
transcription regulator activity 5.9551E-4 4 339 3 6292
binding 1.7823E-3 4 1294 4 6292

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