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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Las17. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BZZ1
  • cytoplasm
  • actin cortical patch
  • response to salt stress
  • actin filament organization
  • endocytosis
  • molecular_function
  • GAL2
  • plasma membrane
  • galactose metabolic process
  • galactose transport
  • galactose transmembrane transporter activity
  • glucose transmembrane transporter activity
  • HXT7
  • mitochondrion
  • plasma membrane
  • hexose transport
  • fructose transmembrane transporter activity
  • glucose transmembrane transporter activity
  • mannose transmembrane transporter activity
  • LAS17
  • cytoplasm
  • actin cortical patch
  • bipolar cellular bud site selection
  • actin polymerization or depolymerization
  • response to osmotic stress
  • cytokinesis
  • actin filament organization
  • endocytosis
  • cytoskeletal protein binding
  • PEP1
  • Golgi apparatus
  • vacuolar transport
  • protein targeting to vacuole
  • signal sequence binding
  • PHO84
  • integral to plasma membrane
  • phosphate transport
  • manganese ion transport
  • inorganic phosphate transmembrane transporter activity
  • manganese ion transmembrane transporter activity
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RVS167
  • actin cortical patch
  • vesicle-mediated transport
  • bipolar cellular bud site selection
  • response to osmotic stress
  • endocytosis
  • cytoskeletal protein binding
  • SLA1
  • actin cortical patch
  • bipolar cellular bud site selection
  • cellular cell wall organization
  • actin filament organization
  • endocytosis
  • actin cortical patch assembly
  • ubiquitin binding
  • cytoskeletal protein binding
  • protein binding, bridging
  • SQT1
  • cytoplasm
  • cytosol
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • VMA6
  • vacuolar proton-transporting V-type ATPase, V0 domain
  • vacuolar membrane
  • vacuolar transport
  • vacuolar acidification
  • proton-transporting ATPase activity, rotational mechanism
  • YHM2
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial nucleoid
  • tricarboxylic acid transport
  • mitochondrial genome maintenance
  • DNA binding
  • tricarboxylate secondary active transmembrane transporter activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    actin cortical patch 1.0637E-6 13 41 4 6292
    cortical actin cytoskeleton 2.8079E-6 13 52 4 6292
    cortical cytoskeleton 2.8079E-6 13 52 4 6292
    actin cytoskeleton 2.0217E-5 13 85 4 6292
    cell cortex part 3.2751E-5 13 96 4 6292
    cell cortex 5.403E-5 13 109 4 6292
    cytoskeletal part 5.7608E-4 13 201 4 6292
    cytoskeleton 7.5654E-4 13 216 4 6292
    proteasome regulatory particle 9.7297E-4 13 23 2 6292
    proteasome accessory complex 9.7297E-4 13 23 2 6292
    proteasome complex 4.2134E-3 13 48 2 6292
    cytoplasmic part 6.8899E-3 13 2482 10 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transport 1.7312E-6 13 997 10 6292
    establishment of localization 1.9222E-6 13 1008 10 6292
    localization 3.1027E-6 13 1060 10 6292
    endocytosis 2.3203E-5 13 88 4 6292
    membrane invagination 3.0134E-5 13 94 4 6292
    bipolar cellular bud site selection 3.9744E-5 13 34 3 6292
    actin filament organization 3.1959E-4 13 68 3 6292
    cellular bud site selection 4.1043E-4 13 74 3 6292
    cytokinesis, site selection 4.1043E-4 13 74 3 6292
    response to osmotic stress 4.6149E-4 13 77 3 6292
    cell cycle cytokinesis 5.1647E-4 13 80 3 6292
    cellular membrane organization 5.441E-4 13 198 4 6292
    membrane organization 5.441E-4 13 198 4 6292
    establishment of cell polarity 5.9611E-4 13 84 3 6292
    establishment or maintenance of cell polarity 6.1717E-4 13 85 3 6292
    cell budding 7.297E-4 13 90 3 6292
    asexual reproduction 7.297E-4 13 90 3 6292
    cytokinetic process 7.7815E-4 13 92 3 6292
    monosaccharide transport 1.2455E-3 13 26 2 6292
    hexose transport 1.2455E-3 13 26 2 6292
    cytokinesis 1.3788E-3 13 112 3 6292
    actin cytoskeleton organization 1.4147E-3 13 113 3 6292
    actin filament-based process 1.5643E-3 13 117 3 6292
    response to abiotic stimulus 1.5643E-3 13 117 3 6292
    cell morphogenesis 1.8925E-3 13 125 3 6292
    cellular component morphogenesis 2.5129E-3 13 138 3 6292
    carbohydrate transport 2.797E-3 13 39 2 6292
    cell division 2.8937E-3 13 145 3 6292
    vesicle-mediated transport 4.0576E-3 13 340 4 6292
    tricarboxylic acid transport 4.1283E-3 13 2 1 6292
    galactose transport 4.1283E-3 13 2 1 6292
    reproduction of a single-celled organism 8.9563E-3 13 217 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoskeletal protein binding 2.0956E-4 13 59 3 6292
    transmembrane transporter activity 2.4533E-4 13 306 5 6292
    glucose transmembrane transporter activity 5.9184E-4 13 18 2 6292
    protein binding, bridging 7.3325E-4 13 20 2 6292
    hexose transmembrane transporter activity 8.0949E-4 13 21 2 6292
    monosaccharide transmembrane transporter activity 8.0949E-4 13 21 2 6292
    transporter activity 8.9058E-4 13 404 5 6292
    sugar transmembrane transporter activity 9.7297E-4 13 23 2 6292
    secondary active transmembrane transporter activity 1.2455E-3 13 26 2 6292
    carbohydrate transmembrane transporter activity 1.6593E-3 13 30 2 6292
    substrate-specific transmembrane transporter activity 1.673E-3 13 267 4 6292
    active transmembrane transporter activity 1.7235E-3 13 121 3 6292
    substrate-specific transporter activity 3.8874E-3 13 336 4 6292
    tricarboxylate secondary active transmembrane transporter activity 4.1283E-3 13 2 1 6292
    endopeptidase activity 5.308E-3 13 54 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle