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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sir3. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADH6
  • soluble fraction
  • cellular aldehyde metabolic process
  • alcohol metabolic process
  • alcohol dehydrogenase (NADP+) activity
  • COR1
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • CYS4
  • cytoplasm
  • mitochondrion
  • response to drug
  • cysteine biosynthetic process
  • cystathionine beta-synthase activity
  • GAS1
  • fungal-type cell wall
  • mitochondrion
  • plasma membrane
  • filamentous growth
  • cellular cell wall organization
  • 1,3-beta-glucanosyltransferase activity
  • ILV5
  • mitochondrion
  • mitochondrial nucleoid
  • branched chain family amino acid biosynthetic process
  • mitochondrial genome maintenance
  • ketol-acid reductoisomerase activity
  • RNR2
  • nucleus
  • cytoplasm
  • ribonucleoside-diphosphate reductase complex
  • DNA replication
  • ribonucleoside-diphosphate reductase activity
  • SAH1
  • cytoplasm
  • methionine metabolic process
  • selenocysteine metabolic process
  • adenosylhomocysteinase activity
  • SES1
  • cytoplasm
  • seryl-tRNA aminoacylation
  • serine-tRNA ligase activity
  • SIR1
  • chromatin silencing complex
  • establishment of chromatin silencing
  • chromatin silencing at silent mating-type cassette
  • DNA binding
  • chromatin binding
  • SIR3
  • nuclear telomeric heterochromatin
  • mitochondrion
  • nucleolus
  • chromatin silencing complex
  • nuclear telomere cap complex
  • loss of chromatin silencing involved in replicative cell aging
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • structural constituent of chromatin
  • histone binding
  • TEF4
  • mitochondrion
  • ribosome
  • eukaryotic translation elongation factor 1 complex
  • translational elongation
  • translation elongation factor activity
  • TMA29
  • nucleus
  • cytoplasm
  • ribosome
  • metabolic process
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromatin silencing complex 1.1916E-4 12 9 2 6292
    ribonucleoside-diphosphate reductase complex 7.6087E-3 12 4 1 6292
    eukaryotic translation elongation factor 1 complex 9.5026E-3 12 5 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cellular amino acid metabolic process 3.9365E-4 12 199 4 6292
    cellular amine metabolic process 5.9721E-4 12 222 4 6292
    amine metabolic process 8.4079E-4 12 243 4 6292
    cellular amino acid and derivative metabolic process 8.4079E-4 12 243 4 6292
    serine family amino acid metabolic process 1.1399E-3 12 27 2 6292
    sulfur amino acid metabolic process 1.8084E-3 12 34 2 6292
    selenocysteine metabolic process 1.9072E-3 12 1 1 6292
    selenium metabolic process 1.9072E-3 12 1 1 6292
    carboxylic acid metabolic process 2.7174E-3 12 333 4 6292
    organic acid metabolic process 2.7174E-3 12 333 4 6292
    oxoacid metabolic process 2.7174E-3 12 333 4 6292
    cellular ketone metabolic process 3.1264E-3 12 346 4 6292
    metabolic process 3.2647E-3 12 3157 11 6292
    cysteine biosynthetic process 3.811E-3 12 2 1 6292
    seryl-tRNA aminoacylation 3.811E-3 12 2 1 6292
    establishment of chromatin silencing 5.7116E-3 12 3 1 6292
    cysteine metabolic process 7.6087E-3 12 4 1 6292
    small molecule metabolic process 9.6932E-3 12 760 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    oxidoreductase activity 1.0483E-4 12 281 5 6292
    trialkylsulfonium hydrolase activity 1.9072E-3 12 1 1 6292
    cystathionine beta-synthase activity 1.9072E-3 12 1 1 6292
    adenosylhomocysteinase activity 1.9072E-3 12 1 1 6292
    ketol-acid reductoisomerase activity 1.9072E-3 12 1 1 6292
    serine-tRNA ligase activity 3.811E-3 12 2 1 6292
    structural constituent of chromatin 3.811E-3 12 2 1 6292
    catalytic activity 4.6325E-3 12 2150 9 6292
    hydrolase activity, acting on ether bonds 5.7116E-3 12 3 1 6292
    alcohol dehydrogenase (NADP+) activity 5.7116E-3 12 3 1 6292
    oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 7.6087E-3 12 4 1 6292
    ribonucleoside-diphosphate reductase activity 7.6087E-3 12 4 1 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8.1285E-3 12 73 2 6292
    oxidoreductase activity, acting on CH or CH2 groups 9.5026E-3 12 5 1 6292
    glucanosyltransferase activity 9.5026E-3 12 5 1 6292
    1,3-beta-glucanosyltransferase activity 9.5026E-3 12 5 1 6292
    oxidoreductase activity, acting on CH-OH group of donors 9.9369E-3 12 81 2 6292

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