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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Mus81. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC5
  • nucleus
  • cellular bud neck
  • spindle pole
  • DNA-dependent DNA replication
  • protein amino acid phosphorylation
  • protein kinase activity
  • HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • HHO1
  • nucleus
  • nuclear nucleosome
  • regulation of transcription, DNA-dependent
  • negative regulation of DNA recombination
  • DNA binding
  • ICP55
  • mitochondrial matrix
  • mitochondrion
  • proteolysis
  • X-Pro aminopeptidase activity
  • metalloendopeptidase activity
  • LOC1
  • nucleus
  • intracellular mRNA localization
  • ribosomal large subunit biogenesis
  • mRNA binding
  • MGM101
  • mitochondrial chromosome
  • mitochondrion
  • mitochondrial nucleoid
  • DNA repair
  • mitochondrial genome maintenance
  • DNA binding
  • MUS81
  • nucleus
  • Holliday junction resolvase complex
  • DNA repair
  • reciprocal meiotic recombination
  • DNA topological change
  • response to DNA damage stimulus
  • endonuclease activity
  • crossover junction endodeoxyribonuclease activity
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • TAF14
  • SWI/SNF complex
  • transcription factor TFIID complex
  • Ino80 complex
  • transcription factor TFIIF complex
  • histone acetyltransferase complex
  • chromatin remodeling
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TMA29
  • nucleus
  • cytoplasm
  • ribosome
  • metabolic process
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
  • YRA1
  • transcription export complex
  • mRNA export from nucleus
  • RNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    non-membrane-bounded organelle 7.9037E-5 12 959 8 6292
    intracellular non-membrane-bounded organelle 7.9037E-5 12 959 8 6292
    nuclear nucleosome 2.1777E-4 12 12 2 6292
    nucleosome 2.1777E-4 12 12 2 6292
    nuclear chromatin 3.0582E-4 12 73 3 6292
    chromatin 3.5814E-4 12 77 3 6292
    nucleus 4.1872E-4 12 2041 10 6292
    organelle lumen 6.9054E-4 12 660 6 6292
    intracellular organelle lumen 6.9054E-4 12 660 6 6292
    membrane-enclosed lumen 9.4976E-4 12 700 6 6292
    chromosome 1.3197E-3 12 274 4 6292
    membrane-bounded organelle 2.1329E-3 12 3771 12 6292
    intracellular membrane-bounded organelle 2.1329E-3 12 3771 12 6292
    histone acetyltransferase complex 3.0173E-3 12 44 2 6292
    mitochondrial chromosome 3.811E-3 12 2 1 6292
    cytoplasmic chromosome 3.811E-3 12 2 1 6292
    replication fork protection complex 3.811E-3 12 2 1 6292
    nuclear chromosome part 4.8752E-3 12 190 3 6292
    protein-DNA complex 5.0209E-3 12 57 2 6292
    intracellular organelle 5.3355E-3 12 4070 12 6292
    organelle 5.3513E-3 12 4071 12 6292
    transcription factor TFIIF complex 5.7116E-3 12 3 1 6292
    Holliday junction resolvase complex 5.7116E-3 12 3 1 6292
    intracellular organelle part 7.3047E-3 12 2282 9 6292
    organelle part 7.3047E-3 12 2282 9 6292
    transcription export complex 7.6087E-3 12 4 1 6292
    nuclear chromosome 8.1053E-3 12 228 3 6292
    nuclear lumen 8.2402E-3 12 453 4 6292
    chromosomal part 9.0195E-3 12 237 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleic acid metabolic process 1.3186E-3 12 1415 8 6292
    histone H3-K79 methylation 1.9072E-3 12 1 1 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.6723E-3 12 1566 8 6292
    DNA metabolic process 3.1073E-3 12 585 5 6292
    histone lysine methylation 3.811E-3 12 2 1 6292
    DNA repair 5.0207E-3 12 192 3 6292
    DNA conformation change 5.1947E-3 12 58 2 6292
    cellular nitrogen compound metabolic process 6.1479E-3 12 1770 8 6292
    nitrogen compound metabolic process 6.653E-3 12 1791 8 6292
    response to DNA damage stimulus 8.915E-3 12 236 3 6292
    macromolecule metabolic process 9.0889E-3 12 2349 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleic acid binding 7.2534E-4 12 666 6 6292
    X-Pro aminopeptidase activity 3.811E-3 12 2 1 6292
    crossover junction endodeoxyribonuclease activity 5.7116E-3 12 3 1 6292
    endodeoxyribonuclease activity, producing 3'-phosphomonoesters 7.6087E-3 12 4 1 6292

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