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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Dbf2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CYR1
  • mitochondrion
  • plasma membrane
  • G-protein signaling, coupled to cAMP nucleotide second messenger
  • Ras protein signal transduction
  • age-dependent response to oxidative stress involved in chronological cell aging
  • meiosis
  • adenylate cyclase activity
  • DBF2
  • cellular bud neck
  • spindle pole body
  • nuclear division
  • protein amino acid phosphorylation
  • protein serine/threonine kinase activity
  • FAA1
  • lipid particle
  • mitochondrion
  • mitochondrial outer membrane
  • lipid transport
  • lipid metabolic process
  • N-terminal protein myristoylation
  • long-chain fatty acid-CoA ligase activity
  • GPH1
  • cytoplasm
  • glycogen catabolic process
  • glycogen phosphorylase activity
  • MOB1
  • cellular bud neck
  • spindle pole body
  • regulation of exit from mitosis
  • protein amino acid phosphorylation
  • kinase regulator activity
  • NPA3
  • cytoplasm
  • biological_process
  • ATPase activity
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • protein metabolic process
  • vacuolar acidification
  • intron homing
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
  • TPS1
  • cytoplasm
  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
  • carbohydrate metabolic process
  • response to drug
  • trehalose biosynthetic process
  • response to stress
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome regulatory particle 9.1897E-6 12 23 3 6292
    proteasome accessory complex 9.1897E-6 12 23 3 6292
    proteasome complex 8.7367E-5 12 48 3 6292
    proteasome regulatory particle, base subcomplex 1.1916E-4 12 9 2 6292
    microtubule organizing center 6.105E-3 12 63 2 6292
    spindle pole body 6.105E-3 12 63 2 6292
    spindle pole 7.0833E-3 12 68 2 6292
    alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) 7.6087E-3 12 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    macromolecule catabolic process 1.7157E-3 12 294 4 6292
    protein metabolic process 2.0859E-3 12 1136 7 6292
    modification-dependent protein catabolic process 2.7899E-3 12 156 3 6292
    ubiquitin-dependent protein catabolic process 2.7899E-3 12 156 3 6292
    proteolysis involved in cellular protein catabolic process 2.9455E-3 12 159 3 6292
    modification-dependent macromolecule catabolic process 3.2166E-3 12 164 3 6292
    cellular protein catabolic process 3.6215E-3 12 171 3 6292
    proteolysis 4.7323E-3 12 188 3 6292
    protein catabolic process 4.8034E-3 12 189 3 6292
    G-protein signaling, coupled to cyclic nucleotide second messenger 5.7116E-3 12 3 1 6292
    G-protein signaling, coupled to cAMP nucleotide second messenger 5.7116E-3 12 3 1 6292
    cellular protein metabolic process 8.8666E-3 12 1074 6 6292
    protein myristoylation 9.5026E-3 12 5 1 6292
    N-terminal protein lipidation 9.5026E-3 12 5 1 6292
    N-terminal protein myristoylation 9.5026E-3 12 5 1 6292
    protein amino acid myristoylation 9.5026E-3 12 5 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATPase activity 4.9225E-4 12 211 4 6292
    glycogen phosphorylase activity 1.9072E-3 12 1 1 6292
    phosphorus-oxygen lyase activity 1.9072E-3 12 1 1 6292
    adenylate cyclase activity 1.9072E-3 12 1 1 6292
    phosphorylase activity 1.9072E-3 12 1 1 6292
    nucleoside-triphosphatase activity 2.5994E-3 12 329 4 6292
    hydrolase activity, acting on acid anhydrides 3.3636E-3 12 353 4 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 3.3636E-3 12 353 4 6292
    pyrophosphatase activity 3.3636E-3 12 353 4 6292
    cyclase activity 3.811E-3 12 2 1 6292
    endopeptidase activity 4.5161E-3 12 54 2 6292
    catalytic activity 4.6325E-3 12 2150 9 6292
    alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 5.7116E-3 12 3 1 6292
    transferase activity, transferring hexosyl groups 9.7018E-3 12 80 2 6292

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