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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rpc40. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADR1
  • nucleus
  • regulation of carbohydrate metabolic process
  • transcription
  • peroxisome organization
  • negative regulation of transcription from RNA polymerase II promoter by glucose
  • transcription factor activity
  • DOP1
  • cytoplasm
  • mitochondrion
  • cell morphogenesis
  • molecular_function
  • ECM29
  • nucleus
  • cytoplasm
  • proteasome complex
  • protein catabolic process
  • protein binding
  • KAP122
  • cytoplasm
  • nuclear pore
  • protein import into nucleus
  • response to drug
  • regulation of cell size
  • protein transmembrane transporter activity
  • MET18
  • nucleoplasm
  • telomere maintenance
  • nucleotide-excision repair
  • transcription from RNA polymerase II promoter
  • methionine metabolic process
  • RNA polymerase II transcription factor activity
  • RPA135
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPA190
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • DNA-directed RNA polymerase activity
  • RPC40
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPO31
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • DNA-directed RNA polymerase activity
  • SRY1
  • cellular_component
  • cellular amino acid derivative catabolic process
  • threo-3-hydroxyaspartate ammonia-lyase activity
  • serine racemase activity
  • YER138C
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • DNA-directed DNA polymerase activity
  • RNA-directed DNA polymerase activity
  • RNA binding
  • protein binding
  • ribonuclease activity
  • peptidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase complex 1.5536E-7 11 31 4 6292
    nuclear DNA-directed RNA polymerase complex 1.5536E-7 11 31 4 6292
    DNA-directed RNA polymerase complex 1.5536E-7 11 31 4 6292
    DNA-directed RNA polymerase I complex 1.4322E-6 11 14 3 6292
    nucleolar part 5.4203E-5 11 45 3 6292
    DNA-directed RNA polymerase III complex 3.7257E-4 11 17 2 6292
    nuclear lumen 6.0735E-4 11 453 5 6292
    nuclear part 8.5482E-4 11 1103 7 6292
    nucleus 1.0879E-3 11 2041 9 6292
    organelle lumen 3.369E-3 11 660 5 6292
    intracellular organelle lumen 3.369E-3 11 660 5 6292
    membrane-enclosed lumen 4.3723E-3 11 700 5 6292
    nucleolus 5.0257E-3 11 211 3 6292
    protein complex 6.9351E-3 11 1137 6 6292
    nucleoplasm 9.3783E-3 11 264 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription from RNA polymerase I promoter 1.5733E-5 11 30 3 6292
    transcription, DNA-dependent 8.2682E-5 11 503 6 6292
    RNA biosynthetic process 8.7445E-5 11 508 6 6292
    transcription 1.3973E-4 11 552 6 6292
    transcription from RNA polymerase III promoter 1.8876E-3 11 38 2 6292
    RNA metabolic process 2.7847E-3 11 954 6 6292
    cellular macromolecule biosynthetic process 8.6337E-3 11 1187 6 6292
    macromolecule biosynthetic process 8.7077E-3 11 1189 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase activity 2.2838E-7 11 34 4 6292
    DNA-directed RNA polymerase activity 2.2838E-7 11 34 4 6292
    nucleotidyltransferase activity 5.1881E-6 11 168 5 6292
    transferase activity, transferring phosphorus-containing groups 4.2699E-4 11 420 5 6292
    threo-3-hydroxyaspartate ammonia-lyase activity 1.7483E-3 11 1 1 6292
    serine racemase activity 1.7483E-3 11 1 1 6292
    racemase and epimerase activity, acting on amino acids and derivatives 3.4937E-3 11 2 1 6292
    amino-acid racemase activity 3.4937E-3 11 2 1 6292
    transferase activity 7.7048E-3 11 797 5 6292
    racemase and epimerase activity 8.7135E-3 11 5 1 6292

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