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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Met30. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 5 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC53
  • SCF ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding, bridging
  • MET30
  • nucleus
  • SCF ubiquitin ligase complex
  • nuclear SCF ubiquitin ligase complex
  • response to arsenic
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • response to cadmium ion
  • cell cycle
  • protein ubiquitination
  • protein binding
  • MET4
  • nucleus
  • sulfur amino acid metabolic process
  • response to arsenic
  • response to cadmium ion
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription coactivator activity
  • SKP1
  • RAVE complex
  • nucleus
  • cytoplasm
  • CBF3 complex
  • SCF ubiquitin ligase complex
  • kinetochore
  • G2/M transition of mitotic cell cycle
  • protein complex assembly
  • regulation of exit from mitosis
  • G1/S transition of mitotic cell cycle
  • cytokinesis
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • regulation of protein complex assembly
  • protein neddylation
  • kinetochore assembly
  • vacuolar acidification
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding
  • UBI4
  • cytoplasm
  • protein deubiquitination
  • ascospore formation
  • protein polyubiquitination
  • protein monoubiquitination
  • response to stress
  • protein ubiquitination
  • protein tag
  • ATP-dependent protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF ubiquitin ligase complex 3.9687E-8 5 11 3 6292
    cullin-RING ubiquitin ligase complex 8.7489E-8 5 14 3 6292
    ubiquitin ligase complex 2.9457E-6 5 43 3 6292
    nuclear SCF ubiquitin ligase complex 1.5888E-3 5 2 1 6292
    RAVE complex 2.3825E-3 5 3 1 6292
    CBF3 complex 3.1756E-3 5 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 8.4265E-9 5 7 3 6292
    protein ubiquitination 5.1484E-8 5 65 4 6292
    protein modification by small protein conjugation 1.6105E-7 5 86 4 6292
    protein modification by small protein conjugation or removal 5.0423E-7 5 114 4 6292
    response to cadmium ion 5.0479E-6 5 5 2 6292
    proteasomal protein catabolic process 1.2428E-5 5 69 3 6292
    proteasomal ubiquitin-dependent protein catabolic process 1.2428E-5 5 69 3 6292
    response to arsenic 1.8149E-5 5 9 2 6292
    protein ubiquitination during ubiquitin-dependent protein catabolic process 2.771E-5 5 11 2 6292
    post-translational protein modification 4.8711E-5 5 357 4 6292
    response to metal ion 7.6913E-5 5 18 2 6292
    modification-dependent protein catabolic process 1.4416E-4 5 156 3 6292
    ubiquitin-dependent protein catabolic process 1.4416E-4 5 156 3 6292
    proteolysis involved in cellular protein catabolic process 1.5258E-4 5 159 3 6292
    modification-dependent macromolecule catabolic process 1.6732E-4 5 164 3 6292
    protein modification process 1.8329E-4 5 499 4 6292
    cellular protein catabolic process 1.895E-4 5 171 3 6292
    G2/M transition of mitotic cell cycle 2.0338E-4 5 29 2 6292
    proteolysis 2.5118E-4 5 188 3 6292
    protein catabolic process 2.5517E-4 5 189 3 6292
    response to inorganic substance 2.9749E-4 5 35 2 6292
    macromolecule modification 3.0739E-4 5 569 4 6292
    G1/S transition of mitotic cell cycle 6.0956E-4 5 50 2 6292
    cellular macromolecule catabolic process 6.9359E-4 5 265 3 6292
    macromolecule catabolic process 9.4145E-4 5 294 3 6292
    interphase of mitotic cell cycle 2.2823E-3 5 97 2 6292
    interphase 2.2823E-3 5 97 2 6292
    centromere complex assembly 2.3825E-3 5 3 1 6292
    kinetochore assembly 2.3825E-3 5 3 1 6292
    kinetochore organization 2.3825E-3 5 3 1 6292
    cellular catabolic process 2.5772E-3 5 415 3 6292
    cellular protein metabolic process 3.6498E-3 5 1074 4 6292
    catabolic process 4.3165E-3 5 496 3 6292
    protein metabolic process 4.528E-3 5 1136 4 6292
    cell cycle 5.0831E-3 5 525 3 6292
    protein neddylation 5.552E-3 5 7 1 6292
    cellular macromolecule metabolic process 6.2991E-3 5 2285 5 6292
    macromolecule metabolic process 7.2329E-3 5 2349 5 6292
    regulation of protein complex assembly 8.7135E-3 5 11 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein binding 8.5781E-6 5 612 5 6292
    DNA replication origin binding 3.9273E-5 5 13 2 6292
    binding 3.6564E-4 5 1294 5 6292
    sequence-specific DNA binding 6.0956E-4 5 50 2 6292
    ubiquitin-protein ligase activity 7.924E-4 5 57 2 6292
    ATP-dependent protein binding 7.9466E-4 5 1 1 6292
    small conjugating protein ligase activity 9.3736E-4 5 62 2 6292
    acid-amino acid ligase activity 1.2283E-3 5 71 2 6292
    ligase activity, forming carbon-nitrogen bonds 2.1446E-3 5 94 2 6292
    ligase activity 5.3853E-3 5 150 2 6292
    protein tag 6.3431E-3 5 8 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle