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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ela1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
EBP2
  • nucleolus
  • nuclear division
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • ELA1
  • transcription elongation factor complex
  • Cul3-RING ubiquitin ligase complex
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • RNA elongation from RNA polymerase II promoter
  • transcription elongation regulator activity
  • IMD3
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • IMD4
  • cytoplasm
  • biological_process
  • IMP dehydrogenase activity
  • MSS116
  • mitochondrial matrix
  • mitochondrion
  • RNA splicing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP1
  • nuclear outer membrane
  • nucleolus
  • ribosome
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • RNA methylation
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • snoRNA 3'-end processing
  • methyltransferase activity
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • PET127
  • mitochondrion
  • mitochondrial envelope
  • RNA processing
  • molecular_function
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • PWP1
  • nucleus
  • cytoplasm
  • nucleolus
  • rRNA processing
  • molecular_function
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • RRP12
  • nucleus
  • ribosome
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • TIS11
  • nucleus
  • cytoplasm
  • cellular iron ion homeostasis
  • mRNA catabolic process
  • mRNA binding
  • YER077C
  • mitochondrion
  • biological_process
  • molecular_function
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 8.7226E-10 17 211 9 6292
    nuclear lumen 4.1733E-8 17 453 10 6292
    organelle lumen 1.0701E-7 17 660 11 6292
    intracellular organelle lumen 1.0701E-7 17 660 11 6292
    membrane-enclosed lumen 1.9761E-7 17 700 11 6292
    non-membrane-bounded organelle 4.5136E-5 17 959 10 6292
    intracellular non-membrane-bounded organelle 4.5136E-5 17 959 10 6292
    nuclear part 1.5531E-4 17 1103 10 6292
    nucleus 1.4135E-3 17 2041 12 6292
    intracellular organelle part 4.1965E-3 17 2282 12 6292
    organelle part 4.1965E-3 17 2282 12 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 6.8175E-8 17 346 9 6292
    ribonucleoprotein complex biogenesis 1.3385E-7 17 374 9 6292
    ribosomal large subunit biogenesis 5.6606E-7 17 65 5 6292
    rRNA metabolic process 9.7053E-7 17 137 6 6292
    RNA metabolic process 4.7296E-6 17 954 11 6292
    rRNA processing 1.6387E-5 17 128 5 6292
    cellular component biogenesis 2.462E-5 17 694 9 6292
    RNA processing 3.1795E-5 17 380 7 6292
    ncRNA metabolic process 3.7077E-5 17 257 6 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.3083E-5 17 1566 12 6292
    ncRNA processing 1.9661E-4 17 215 5 6292
    nucleic acid metabolic process 2.2727E-4 17 1415 11 6292
    cellular nitrogen compound metabolic process 3.3419E-4 17 1770 12 6292
    nitrogen compound metabolic process 3.7731E-4 17 1791 12 6292
    maturation of SSU-rRNA 4.8512E-4 17 59 3 6292
    gene expression 2.9315E-3 17 1283 9 6292
    ribosomal large subunit assembly 5.2962E-3 17 41 2 6292
    GTP biosynthetic process 5.3968E-3 17 2 1 6292
    ribosomal subunit assembly 9.3809E-3 17 55 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    IMP dehydrogenase activity 2.0582E-5 17 3 2 6292
    RNA binding 2.267E-3 17 367 5 6292
    7S RNA binding 2.7018E-3 17 1 1 6292
    mRNA binding 3.8798E-3 17 35 2 6292
    5S rRNA binding 5.3968E-3 17 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle