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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Bud20. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 28 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AFG2
  • intracellular
  • response to drug
  • ATPase activity
  • ALB1
  • nucleus
  • cytoplasm
  • ribosome
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • ARX1
  • cytoplasm
  • nucleoplasm
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • BUD20
  • nucleus
  • cellular bud site selection
  • ribosome biogenesis
  • molecular_function
  • EHD3
  • mitochondrion
  • fatty acid beta-oxidation
  • endocytosis
  • 3-hydroxyisobutyryl-CoA hydrolase activity
  • FYV4
  • mitochondrion
  • telomere maintenance
  • molecular_function
  • HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • HTA1
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • HTB1
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • postreplication repair
  • DNA binding
  • HTB2
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • DNA binding
  • LHP1
  • nucleus
  • nucleolus
  • nucleoplasm
  • tRNA processing
  • RNA binding
  • MAM33
  • mitochondrial matrix
  • mitochondrion
  • response to drug
  • aerobic respiration
  • molecular_function
  • MNP1
  • mitochondrion
  • mitochondrial ribosome
  • aerobic respiration
  • translation
  • structural constituent of ribosome
  • MRPS16
  • mitochondrion
  • mitochondrial small ribosomal subunit
  • translation
  • structural constituent of ribosome
  • NMD3
  • cytosol
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • RNA binding
  • protein binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP13
  • nucleolus
  • nucleoplasm
  • ribosome biogenesis
  • RNA binding
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • PWP1
  • nucleus
  • cytoplasm
  • nucleolus
  • rRNA processing
  • molecular_function
  • RIX1
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • RSM24
  • mitochondrion
  • mitochondrial small ribosomal subunit
  • aerobic respiration
  • translation
  • structural constituent of ribosome
  • RSM25
  • mitochondrion
  • mitochondrial small ribosomal subunit
  • translation
  • structural constituent of ribosome
  • YBL044W
  • cellular_component
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    organelle lumen 1.642E-9 28 660 16 6292
    intracellular organelle lumen 1.642E-9 28 660 16 6292
    membrane-enclosed lumen 3.9288E-9 28 700 16 6292
    non-membrane-bounded organelle 4.5919E-8 28 959 17 6292
    intracellular non-membrane-bounded organelle 4.5919E-8 28 959 17 6292
    nuclear nucleosome 1.5159E-7 28 12 4 6292
    nucleosome 1.5159E-7 28 12 4 6292
    nuclear lumen 1.6678E-6 28 453 11 6292
    nucleolus 2.441E-6 28 211 8 6292
    nuclear part 1.5818E-5 28 1103 15 6292
    protein-DNA complex 1.0542E-4 28 57 4 6292
    intracellular organelle part 1.604E-4 28 2282 20 6292
    organelle part 1.604E-4 28 2282 20 6292
    nuclear chromatin 2.766E-4 28 73 4 6292
    chromatin 3.3972E-4 28 77 4 6292
    mitochondrial small ribosomal subunit 4.6968E-4 28 35 3 6292
    organellar small ribosomal subunit 4.6968E-4 28 35 3 6292
    nucleus 5.2755E-4 28 2041 18 6292
    mitochondrial ribosome 6.1645E-4 28 90 4 6292
    organellar ribosome 6.1645E-4 28 90 4 6292
    preribosome, large subunit precursor 6.7442E-4 28 9 2 6292
    membrane-bounded organelle 6.7993E-4 28 3771 25 6292
    intracellular membrane-bounded organelle 6.7993E-4 28 3771 25 6292
    mitochondrial matrix 9.4251E-4 28 176 5 6292
    mitochondrial lumen 9.4251E-4 28 176 5 6292
    ribonucleoprotein complex 1.345E-3 28 514 8 6292
    intracellular organelle 3.2839E-3 28 4070 25 6292
    organelle 3.3003E-3 28 4071 25 6292
    small ribosomal subunit 3.9863E-3 28 73 3 6292
    nucleoplasm 5.5642E-3 28 264 5 6292
    nuclear outer membrane 6.311E-3 28 86 3 6292
    ribosome 8.2423E-3 28 290 5 6292
    nuclear membrane 8.8005E-3 28 97 3 6292
    replication fork protection complex 8.8811E-3 28 2 1 6292
    nuclear chromosome part 9.3488E-3 28 190 4 6292
    preribosome 9.8121E-3 28 34 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal large subunit biogenesis 2.1997E-10 28 65 8 6292
    ribosome biogenesis 5.9525E-10 28 346 13 6292
    ribonucleoprotein complex biogenesis 1.5603E-9 28 374 13 6292
    cellular component biogenesis 3.1767E-7 28 694 14 6292
    chromatin assembly or disassembly 1.4946E-5 28 35 4 6292
    establishment of ribosome localization 1.9165E-4 28 26 3 6292
    ribosome localization 1.9165E-4 28 26 3 6292
    ribosomal subunit export from nucleus 1.9165E-4 28 26 3 6292
    rRNA metabolic process 2.9868E-4 28 137 5 6292
    ncRNA metabolic process 7.7257E-4 28 257 6 6292
    establishment of organelle localization 1.7739E-3 28 55 3 6292
    processing of 27S pre-rRNA 2.2052E-3 28 16 2 6292
    rRNA processing 2.2914E-3 28 128 4 6292
    ncRNA processing 2.298E-3 28 215 5 6292
    cellular process 4.1574E-3 28 4426 26 6292
    histone H3-K79 methylation 4.4501E-3 28 1 1 6292
    aerobic respiration 5.7167E-3 28 83 3 6292
    organelle localization 6.109E-3 28 85 3 6292
    cellular respiration 8.8005E-3 28 97 3 6292
    histone lysine methylation 8.8811E-3 28 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleic acid binding 1.7083E-3 28 666 9 6292
    3-hydroxyisobutyryl-CoA hydrolase activity 4.4501E-3 28 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle