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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22.
Notes: From the published set of protein complexes (core proteins only)
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARX1
  • cytoplasm
  • nucleoplasm
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • FPR4
  • nucleus
  • chromatin
  • chromatin silencing at rDNA
  • negative regulation of histone H3-K36 methylation
  • ribosome biogenesis
  • histone peptidyl-prolyl isomerization
  • positive regulation of transcription from RNA polymerase II promoter
  • nucleosome assembly
  • peptidyl-prolyl cis-trans isomerase activity
  • histone binding
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOG2
  • nucleus
  • nucleolus
  • nucleoplasm
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • GTPase activity
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • SDA1
  • nucleus
  • ribosome biogenesis
  • traversing start control point of mitotic cell cycle
  • ribosome assembly
  • actin cytoskeleton organization
  • molecular_function
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 6.1882E-10 12 211 8 6292
    nuclear lumen 8.7176E-9 12 453 9 6292
    organelle lumen 2.4016E-7 12 660 9 6292
    intracellular organelle lumen 2.4016E-7 12 660 9 6292
    membrane-enclosed lumen 4.0143E-7 12 700 9 6292
    nucleus 1.3278E-6 12 2041 12 6292
    non-membrane-bounded organelle 6.103E-6 12 959 9 6292
    intracellular non-membrane-bounded organelle 6.103E-6 12 959 9 6292
    nuclear part 2.0097E-5 12 1103 9 6292
    preribosome, large subunit precursor 1.1916E-4 12 9 2 6292
    organelle part 1.1585E-3 12 2282 10 6292
    intracellular organelle part 1.1585E-3 12 2282 10 6292
    preribosome 1.8084E-3 12 34 2 6292
    membrane-bounded organelle 2.1329E-3 12 3771 12 6292
    intracellular membrane-bounded organelle 2.1329E-3 12 3771 12 6292
    intracellular organelle 5.3355E-3 12 4070 12 6292
    organelle 5.3513E-3 12 4071 12 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 6.3713E-16 12 346 12 6292
    ribonucleoprotein complex biogenesis 1.6448E-15 12 374 12 6292
    cellular component biogenesis 2.9777E-12 12 694 12 6292
    ribosomal large subunit biogenesis 6.8582E-12 12 65 7 6292
    processing of 27S pre-rRNA 2.9278E-6 12 16 3 6292
    ribosome assembly 4.5342E-6 12 64 4 6292
    organelle assembly 6.1378E-6 12 69 4 6292
    cellular macromolecular complex assembly 1.2874E-5 12 182 5 6292
    establishment of ribosome localization 1.3448E-5 12 26 3 6292
    ribosome localization 1.3448E-5 12 26 3 6292
    ribosomal subunit export from nucleus 1.3448E-5 12 26 3 6292
    ribonucleoprotein complex assembly 1.9376E-5 12 92 4 6292
    cellular macromolecular complex subunit organization 7.1002E-5 12 259 5 6292
    rRNA processing 7.1288E-5 12 128 4 6292
    rRNA metabolic process 9.2981E-5 12 137 4 6292
    macromolecular complex assembly 1.0483E-4 12 281 5 6292
    establishment of organelle localization 1.3153E-4 12 55 3 6292
    obsolete_biological_process 1.7064E-4 12 60 3 6292
    macromolecular complex subunit organization 3.2502E-4 12 357 5 6292
    cellular component assembly 4.624E-4 12 385 5 6292
    organelle localization 4.7942E-4 12 85 3 6292
    ncRNA processing 5.2873E-4 12 215 4 6292
    nuclear export 8.419E-4 12 103 3 6292
    ncRNA metabolic process 1.0381E-3 12 257 4 6292
    nuclear transport 1.6541E-3 12 130 3 6292
    nucleocytoplasmic transport 1.6541E-3 12 130 3 6292
    regulation of histone methylation 1.9072E-3 12 1 1 6292
    negative regulation of histone methylation 1.9072E-3 12 1 1 6292
    negative regulation of histone modification 1.9072E-3 12 1 1 6292
    regulation of histone modification 1.9072E-3 12 1 1 6292
    negative regulation of histone H3-K36 methylation 1.9072E-3 12 1 1 6292
    regulation of histone H3-K36 methylation 1.9072E-3 12 1 1 6292
    protein peptidyl-prolyl isomerization 1.9072E-3 12 1 1 6292
    histone peptidyl-prolyl isomerization 1.9072E-3 12 1 1 6292
    histone H3-K36 methylation 1.9072E-3 12 1 1 6292
    ribosomal large subunit assembly 2.6238E-3 12 41 2 6292
    histone lysine methylation 3.811E-3 12 2 1 6292
    regulation of chromosome organization 3.811E-3 12 2 1 6292
    RNA processing 4.3958E-3 12 380 4 6292
    ribosomal subunit assembly 4.6816E-3 12 55 2 6292
    negative regulation of protein modification process 7.6087E-3 12 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal large subunit binding 1.9072E-3 12 1 1 6292
    7S RNA binding 1.9072E-3 12 1 1 6292
    5S rRNA binding 3.811E-3 12 2 1 6292
    GTPase activity 5.7327E-3 12 61 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle