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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
KEM1
  • cytoplasm
  • cytoplasmic mRNA processing body
  • nuclear outer membrane
  • filamentous growth
  • response to exogenous dsRNA
  • telomere maintenance
  • traversing start control point of mitotic cell cycle
  • karyogamy involved in conjugation with cellular fusion
  • mRNA catabolic process
  • 5'-3' exoribonuclease activity
  • deoxyribonuclease activity
  • recombinase activity
  • LSM1
  • mRNA cap binding complex
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • RNA binding
  • RNA cap binding
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM3
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM4
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM5
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM6
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM7
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • telomere maintenance
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM8
  • nucleus
  • U4/U6 x U5 tri-snRNP complex
  • U6 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PAT1
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • chromosome segregation
  • regulation of translational initiation
  • molecular_function
  • PRP24
  • U6 snRNP
  • spliceosome assembly
  • assembly of spliceosomal tri-snRNP
  • nucleic acid binding
  • nucleotide binding
  • U6 snRNA binding
  • RNA binding
  • snRNA binding
  • YGR054W
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U6 snRNP 1.3443E-21 12 11 8 6292
    small nuclear ribonucleoprotein complex 3.0635E-14 12 63 8 6292
    U4/U6 x U5 tri-snRNP complex 3.3932E-14 12 32 7 6292
    ribonucleoprotein complex 7.8427E-14 12 514 12 6292
    small nucleolar ribonucleoprotein complex 1.5905E-9 12 72 6 6292
    macromolecular complex 9.1989E-8 12 1635 12 6292
    nucleolus 1.0345E-6 12 211 6 6292
    cytoplasmic mRNA processing body 2.3814E-6 12 15 3 6292
    nuclear part 2.0097E-5 12 1103 9 6292
    nuclear lumen 8.566E-5 12 453 6 6292
    organelle lumen 6.9054E-4 12 660 6 6292
    intracellular organelle lumen 6.9054E-4 12 660 6 6292
    non-membrane-bounded organelle 7.3226E-4 12 959 7 6292
    intracellular non-membrane-bounded organelle 7.3226E-4 12 959 7 6292
    membrane-enclosed lumen 9.4976E-4 12 700 6 6292
    nucleus 3.0954E-3 12 2041 9 6292
    mRNA cap binding complex 5.7116E-3 12 3 1 6292
    organelle part 7.3047E-3 12 2282 9 6292
    intracellular organelle part 7.3047E-3 12 2282 9 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA catabolic process 2.8688E-16 12 69 9 6292
    mRNA metabolic process 6.0458E-16 12 213 11 6292
    RNA catabolic process 1.1683E-15 12 80 9 6292
    nuclear mRNA splicing, via spliceosome 1.3266E-12 12 99 8 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.4412E-12 12 100 8 6292
    RNA splicing, via transesterification reactions 2.5142E-12 12 107 8 6292
    RNA splicing 1.4001E-11 12 132 8 6292
    mRNA processing 5.4356E-11 12 156 8 6292
    cellular macromolecule catabolic process 7.1899E-11 12 265 9 6292
    macromolecule catabolic process 1.8321E-10 12 294 9 6292
    cellular catabolic process 4.0021E-9 12 415 9 6292
    RNA metabolic process 9.5918E-9 12 954 11 6292
    catabolic process 1.9467E-8 12 496 9 6292
    RNA processing 6.5836E-8 12 380 8 6292
    nucleic acid metabolic process 6.8885E-7 12 1415 11 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0509E-6 12 1566 11 6292
    cellular macromolecule metabolic process 5.1661E-6 12 2285 12 6292
    gene expression 5.3098E-6 12 1283 10 6292
    macromolecule metabolic process 7.2022E-6 12 2349 12 6292
    cellular nitrogen compound metabolic process 7.6146E-6 12 1770 11 6292
    nitrogen compound metabolic process 8.6368E-6 12 1791 11 6292
    primary metabolic process 8.9282E-5 12 2896 12 6292
    cellular metabolic process 1.5563E-4 12 3033 12 6292
    deadenylation-dependent decapping of nuclear-transcribed mRNA 1.8167E-4 12 11 2 6292
    metabolic process 2.5194E-4 12 3157 12 6292
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1.1399E-3 12 27 2 6292
    nuclear-transcribed mRNA catabolic process 2.2566E-3 12 38 2 6292
    translational initiation 2.752E-3 12 42 2 6292
    spliceosomal snRNP assembly 3.811E-3 12 2 1 6292
    assembly of spliceosomal tri-snRNP 3.811E-3 12 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 1.3376E-9 12 367 9 6292
    nucleic acid binding 8.9829E-9 12 666 10 6292
    binding 5.7622E-6 12 1294 10 6292
    U6 snRNA binding 1.9072E-3 12 1 1 6292
    RNA cap binding 3.811E-3 12 2 1 6292
    5'-3' exoribonuclease activity 3.811E-3 12 2 1 6292
    recombinase activity 7.6087E-3 12 4 1 6292
    snRNA binding 9.5026E-3 12 5 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle