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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADE8
  • nucleus
  • cytoplasm
  • adenine biosynthetic process
  • purine nucleotide biosynthetic process
  • 'de novo' IMP biosynthetic process
  • phosphoribosylglycinamide formyltransferase activity
  • CHZ1
  • nucleus
  • chromatin assembly complex
  • chromatin remodeling
  • histone binding
  • ECM2
  • nucleus
  • cellular cell wall organization
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HCR1
  • eukaryotic translation initiation factor 3 complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • translation
  • translation initiation factor activity
  • rRNA binding
  • HEM12
  • nucleus
  • cytoplasm
  • heme biosynthetic process
  • uroporphyrinogen decarboxylase activity
  • KAP122
  • cytoplasm
  • nuclear pore
  • protein import into nucleus
  • response to drug
  • regulation of cell size
  • protein transmembrane transporter activity
  • NIP1
  • multi-eIF complex
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • PRT1
  • multi-eIF complex
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • RPG1
  • incipient cellular bud site
  • cytoplasm
  • ribosome
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • SUI1
  • multi-eIF complex
  • translational initiation
  • translation initiation factor activity
  • SYH1
  • cytoplasm
  • mitochondrion
  • ribosome
  • biological_process
  • molecular_function
  • TIF34
  • multi-eIF complex
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • TIF35
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • TIF5
  • multi-eIF complex
  • mature ribosome assembly
  • regulation of translational initiation
  • translation initiation factor activity
  • GTPase activator activity
  • YOR052C
  • nucleus
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 3 complex 4.0701E-16 15 7 6 6292
    multi-eIF complex 2.0415E-12 15 8 5 6292
    ribonucleoprotein complex 8.3964E-5 15 514 7 6292
    macromolecular complex 1.6522E-4 15 1635 11 6292
    protein complex 2.1412E-3 15 1137 8 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translational initiation 2.1625E-12 15 42 7 6292
    translation 6.7124E-7 15 376 8 6292
    cellular biosynthetic process 7.5786E-4 15 1567 10 6292
    gene expression 8.9699E-4 15 1283 9 6292
    biosynthetic process 9.1567E-4 15 1602 10 6292
    pigment biosynthetic process 9.8331E-4 15 20 2 6292
    pigment metabolic process 1.1922E-3 15 22 2 6292
    cellular protein metabolic process 1.4572E-3 15 1074 8 6292
    protein metabolic process 2.1286E-3 15 1136 8 6292
    mature ribosome assembly 2.384E-3 15 1 1 6292
    cellular macromolecule biosynthetic process 2.8537E-3 15 1187 8 6292
    macromolecule biosynthetic process 2.8858E-3 15 1189 8 6292
    adenine biosynthetic process 4.7627E-3 15 2 1 6292
    adenine metabolic process 7.136E-3 15 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation initiation factor activity 2.3114E-16 15 27 8 6292
    translation factor activity, nucleic acid binding 1.8143E-14 15 44 8 6292
    nucleic acid binding 4.9401E-5 15 666 8 6292
    binding 1.4204E-4 15 1294 10 6292
    uroporphyrinogen decarboxylase activity 2.384E-3 15 1 1 6292
    phosphoribosylglycinamide formyltransferase activity 2.384E-3 15 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle