YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes:	From the published set of core protein complex predictions.
Complex Size:	33 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
AAR2	U5 snRNP	assembly of spliceosomal tri-snRNP	molecular_function
BRR1	small nuclear ribonucleoprotein complex	spliceosome assembly	RNA binding
BRR2	U4/U6 x U5 tri-snRNP complex U5 snRNP	RNA splicing mRNA metabolic process auxin biosynthetic process mRNA processing spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	ATP-dependent RNA helicase activity
CSE1	nuclear envelope	protein export from nucleus	importin-alpha export receptor activity
LUC7	U1 snRNP	mRNA splice site selection	mRNA binding
MUD1	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
NAM8	commitment complex U1 snRNP	mRNA splice site selection nuclear mRNA splicing, via spliceosome	RNA binding mRNA binding
PRP2	nucleus spliceosomal complex	RNA splicing generation of catalytic spliceosome for first transesterification step mRNA processing	ATP-dependent RNA helicase activity
PRP3	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP31	mitochondrion U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
PRP39	commitment complex U1 snRNP	nuclear mRNA 5'-splice site recognition	pre-mRNA 5'-splice site binding
PRP40	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP42	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP6	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	binding molecular_function
PRP8	U4/U6 x U5 tri-snRNP complex U5 snRNP	nuclear mRNA 3'-splice site recognition nuclear mRNA splicing, via spliceosome	U5 snRNA binding
RRG7	mitochondrion	response to drug	molecular_function
SMB1	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMD1	commitment complex U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SMD2	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMD3	commitment complex U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SME1	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMX2	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMX3	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SNP1	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	U1 snRNA binding mRNA binding
SNU114	U4/U6 x U5 tri-snRNP complex U5 snRNP	generation of catalytic spliceosome for first transesterification step nuclear mRNA splicing, via spliceosome	GTP binding U5 snRNA binding GTPase activity
SNU56	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SNU66	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SNU71	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
TAD2	nucleus cytoplasm	tRNA modification	tRNA-specific adenosine deaminase activity
YDL085C-A	nucleus cytoplasm	biological_process	molecular_function
YHC1	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
YJU2	nucleus	nuclear mRNA splicing, via spliceosome	molecular_function
YNL092W	cellular_component	biological_process	S-adenosylmethionine-dependent methyltransferase activity

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
small nuclear ribonucleoprotein complex	1.0611E-48	33	63	26	6292
U1 snRNP	1.117E-41	33	17	17	6292
U4/U6 x U5 tri-snRNP complex	2.1287E-25	33	32	14	6292
ribonucleoprotein complex	1.5577E-24	33	514	27	6292
U5 snRNP	4.5915E-24	33	14	11	6292
nuclear part	4.832E-17	33	1103	28	6292
commitment complex	4.3037E-14	33	12	7	6292
U2-type spliceosomal complex	4.3037E-14	33	12	7	6292
nucleus	1.4946E-13	33	2041	31	6292
macromolecular complex	2.7053E-11	33	1635	27	6292
spliceosomal complex	4.327E-11	33	45	8	6292
organelle part	1.1758E-8	33	2282	28	6292
intracellular organelle part	1.1758E-8	33	2282	28	6292
membrane-bounded organelle	1.0115E-6	33	3771	32	6292
intracellular membrane-bounded organelle	1.0115E-6	33	3771	32	6292
intracellular organelle	1.0447E-5	33	4070	32	6292
organelle	1.0525E-5	33	4071	32	6292
intracellular part	3.3249E-3	33	4938	32	6292
intracellular	4.1243E-3	33	4975	32	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nuclear mRNA splicing, via spliceosome	1.1268E-47	33	99	28	6292
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1.5638E-47	33	100	28	6292
RNA splicing, via transesterification reactions	1.3991E-46	33	107	28	6292
RNA splicing	1.0866E-43	33	132	28	6292
mRNA processing	1.9026E-41	33	156	28	6292
mRNA metabolic process	2.2961E-37	33	213	28	6292
RNA processing	5.2002E-32	33	380	29	6292
RNA metabolic process	2.6776E-20	33	954	29	6292
gene expression	1.2636E-16	33	1283	29	6292
nucleic acid metabolic process	2.0118E-15	33	1415	29	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.4717E-14	33	1566	29	6292
cellular nitrogen compound metabolic process	1.0539E-12	33	1770	29	6292
nitrogen compound metabolic process	1.4616E-12	33	1791	29	6292
ribonucleoprotein complex assembly	5.937E-10	33	92	9	6292
cellular macromolecule metabolic process	1.1546E-9	33	2285	29	6292
macromolecule metabolic process	2.4321E-9	33	2349	29	6292
mRNA splice site selection	9.3387E-9	33	6	4	6292
spliceosome assembly	2.3614E-8	33	18	5	6292
cellular macromolecular complex assembly	2.4649E-7	33	182	9	6292
primary metabolic process	6.2048E-7	33	2896	29	6292
cellular metabolic process	2.0455E-6	33	3033	29	6292
cellular macromolecular complex subunit organization	4.7782E-6	33	259	9	6292
metabolic process	5.6883E-6	33	3157	29	6292
macromolecular complex assembly	9.3092E-6	33	281	9	6292
spliceosomal conformational changes to generate catalytic conformation	1.081E-5	33	9	3	6292
macromolecular complex subunit organization	6.2971E-5	33	357	9	6292
generation of catalytic spliceosome for first transesterification step	7.9771E-5	33	3	2	6292
ribonucleoprotein complex biogenesis	9.0487E-5	33	374	9	6292
cellular component assembly	1.1324E-4	33	385	9	6292
cellular process	4.6215E-3	33	4426	30	6292
regulation of hormone levels	5.2448E-3	33	1	1	6292
spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	5.2448E-3	33	1	1	6292
nuclear mRNA 5'-splice site recognition	5.2448E-3	33	1	1	6292
auxin biosynthetic process	5.2448E-3	33	1	1	6292
auxin metabolic process	5.2448E-3	33	1	1	6292
hormone metabolic process	5.2448E-3	33	1	1	6292
hormone biosynthetic process	5.2448E-3	33	1	1	6292
cellular component biogenesis	7.7118E-3	33	694	9	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA binding	4.1192E-20	33	367	22	6292
nucleic acid binding	1.5836E-14	33	666	22	6292
mRNA binding	4.8955E-12	33	35	8	6292
binding	1.5243E-10	33	1294	24	6292
snRNA binding	1.3054E-6	33	5	3	6292
U5 snRNA binding	2.6678E-5	33	2	2	6292
pre-mRNA 5'-splice site binding	5.2448E-3	33	1	1	6292
U1 snRNA binding	5.2448E-3	33	1	1	6292
ATP-dependent RNA helicase activity	9.2603E-3	33	28	2	6292
RNA-dependent ATPase activity	9.9138E-3	33	29	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis