YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes:	MIPS hand-curated complex set. MIPS complex ID: 500.40.10
Complex Size:	70 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
RPL10	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	structural constituent of ribosome
RPL11A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	structural constituent of ribosome
RPL11B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	structural constituent of ribosome
RPL12B, RPL12A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome	regulation of translation translational termination ribosomal large subunit assembly translation	RNA binding structural constituent of ribosome
RPL13A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL13B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	telomere maintenance translation	structural constituent of ribosome
RPL14A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL14B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL15A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL15B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL16A	ribonucleoprotein complex cytoplasm large ribosomal subunit cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL16B	ribonucleoprotein complex cytoplasm large ribosomal subunit cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL17A	cytoplasm	translation	structural constituent of ribosome
RPL17B	ribonucleoprotein complex cytoplasm large ribosomal subunit cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL18A, RPL18B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	regulation of translation translation	structural constituent of ribosome
RPL19B, RPL19A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL1A, RPL1B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	regulation of translation RNA processing translation	RNA binding structural constituent of ribosome
RPL20A		translation	structural constituent of ribosome
RPL20B		ribosome biogenesis translation	structural constituent of ribosome
RPL21A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL21B	ribonucleoprotein complex cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL22A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL22B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL23B, RPL23A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	response to drug translation	structural constituent of ribosome
RPL24A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL24B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL25	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	RNA binding structural constituent of ribosome
RPL26A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL26B		translation	RNA binding structural constituent of ribosome
RPL27A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL27B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL28	nucleus	translation	RNA binding structural constituent of ribosome
RPL29	cytoplasm	translation	structural constituent of ribosome
RPL2A, RPL2B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	regulation of translation response to drug translation	RNA binding structural constituent of ribosome rRNA binding
RPL3	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	structural constituent of ribosome
RPL30	cytoplasm	negative regulation of nuclear mRNA splicing, via spliceosome rRNA processing negative regulation of translation translation	structural constituent of ribosome
RPL31A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL31B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL32	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL33A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL33B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL34A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL34B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	telomere maintenance translation	structural constituent of ribosome
RPL35A, RPL35B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular preribosome, large subunit precursor	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation	structural constituent of ribosome
RPL36A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL36B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL37A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL37B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL38	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL39	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL40B, RPL40A
RPL41A, RPL41B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome	translation	structural constituent of ribosome
RPL42B, RPL42A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	response to antibiotic response to cycloheximide translation	structural constituent of ribosome
RPL43B, RPL43A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome metal ion binding
RPL4A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL4B	cytoplasm	translation	structural constituent of ribosome
RPL5		ribosomal large subunit assembly translation	RNA binding structural constituent of ribosome
RPL6A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	RNA binding structural constituent of ribosome
RPL6B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	RNA binding structural constituent of ribosome
RPL7A	ribonucleoprotein complex cytoplasm large ribosomal subunit cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL7B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit large ribosomal subunit ribosome nucleolus intracellular	translation	structural constituent of ribosome
RPL8A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome	translation	structural constituent of ribosome
RPL8B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome	translation	structural constituent of ribosome
RPL9A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL9B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPP0		ribosomal large subunit assembly translational elongation translation	structural constituent of ribosome
RPP1A		telomere maintenance translational elongation translation	structural constituent of ribosome
RPP1B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translational elongation translation	structural constituent of ribosome
RPP2A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translational elongation translation	structural constituent of ribosome
RPP2B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translational elongation translation	structural constituent of ribosome

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
cytosolic large ribosomal subunit	2.6859E-126	70	60	58	6292
cytosolic ribosome	9.3172E-101	70	101	58	6292
large ribosomal subunit	1.1559E-97	70	110	58	6292
cytosolic part	4.4649E-94	70	122	58	6292
ribosomal subunit	3.2821E-81	70	183	58	6292
cytosol	1.5729E-68	70	284	58	6292
ribosome	6.0083E-68	70	290	58	6292
ribonucleoprotein complex	1.6083E-52	70	514	58	6292
non-membrane-bounded organelle	1.5628E-36	70	959	58	6292
intracellular non-membrane-bounded organelle	1.5628E-36	70	959	58	6292
macromolecular complex	1.8225E-23	70	1635	58	6292
organelle part	1.0619E-15	70	2282	58	6292
intracellular organelle part	1.0619E-15	70	2282	58	6292
cytoplasmic part	8.1099E-14	70	2482	58	6292
cytoplasm	4.9675E-9	70	3552	62	6292
intracellular organelle	2.183E-4	70	4070	59	6292
organelle	2.2048E-4	70	4071	59	6292
intracellular part	9.1894E-3	70	4938	63	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
translation	4.6385E-86	70	376	69	6292
cellular protein metabolic process	9.676E-53	70	1074	69	6292
protein metabolic process	5.2051E-51	70	1136	69	6292
cellular macromolecule biosynthetic process	1.1703E-49	70	1187	69	6292
macromolecule biosynthetic process	1.3185E-49	70	1189	69	6292
gene expression	2.8671E-47	70	1283	69	6292
cellular biosynthetic process	3.7449E-41	70	1567	69	6292
biosynthetic process	1.7654E-40	70	1602	69	6292
cellular macromolecule metabolic process	1.0379E-29	70	2285	69	6292
macromolecule metabolic process	7.0714E-29	70	2349	69	6292
primary metabolic process	1.3892E-22	70	2896	69	6292
cellular metabolic process	3.362E-21	70	3033	69	6292
metabolic process	5.301E-20	70	3157	69	6292
ribosomal large subunit assembly	1.2751E-11	70	41	10	6292
ribosomal subunit assembly	2.9434E-10	70	55	10	6292
cellular process	5.318E-10	70	4426	69	6292
ribosome assembly	1.4089E-9	70	64	10	6292
ribosomal large subunit biogenesis	1.6506E-9	70	65	10	6292
organelle assembly	3.0273E-9	70	69	10	6292
ribonucleoprotein complex assembly	5.2478E-8	70	92	10	6292
translational elongation	1.4237E-5	70	29	5	6292
cellular macromolecular complex assembly	2.8182E-5	70	182	10	6292
ribosome biogenesis	9.1583E-5	70	346	13	6292
ribonucleoprotein complex biogenesis	2.0058E-4	70	374	13	6292
regulation of translation	3.944E-4	70	57	5	6292
cellular macromolecular complex subunit organization	5.2467E-4	70	259	10	6292
posttranscriptional regulation of gene expression	5.4143E-4	70	61	5	6292
regulation of cellular protein metabolic process	8.9336E-4	70	68	5	6292
macromolecular complex assembly	9.8964E-4	70	281	10	6292
regulation of protein metabolic process	1.3113E-3	70	74	5	6292
macromolecular complex subunit organization	5.7255E-3	70	357	10	6292
cellular component assembly	9.5934E-3	70	385	10	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
structural constituent of ribosome	9.3432E-106	70	212	69	6292
structural molecule activity	1.6779E-89	70	339	69	6292
RNA binding	1.365E-9	70	367	20	6292
nucleic acid binding	2.2759E-5	70	666	20	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis