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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC73
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
  • DNA recombination
  • histone methylation
  • telomere maintenance
  • RNA elongation from RNA polymerase II promoter
  • RNA polymerase II transcription elongation factor activity
  • CKA1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKA2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKB1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • CKB2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • CTR9
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
  • histone methylation
  • transcription from RNA polymerase II promoter
  • chromosome segregation
  • RNA elongation from RNA polymerase II promoter
  • RNA polymerase II transcription elongation factor activity
  • triplex DNA binding
  • LEO1
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
  • histone methylation
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • RNA polymerase II transcription elongation factor activity
  • PAF1
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
  • DNA recombination
  • histone methylation
  • telomere maintenance
  • RNA elongation from RNA polymerase II promoter
  • RNA polymerase II transcription elongation factor activity
  • POB3
  • nucleus
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • chromatin remodeling
  • DNA-dependent DNA replication
  • chromatin assembly or disassembly
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • chromatin binding
  • RTF1
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
  • histone methylation
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • RNA polymerase II transcription elongation factor activity
  • SPT16
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • transcription elongation factor complex
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription elongation regulator activity
  • RNA polymerase II transcription elongation factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription elongation factor complex 1.0386E-15 11 23 7 6292
    Cdc73/Paf1 complex 3.1457E-13 11 8 5 6292
    protein kinase CK2 complex 5.0581E-12 11 4 4 6292
    protein complex 6.4478E-9 11 1137 11 6292
    DNA-directed RNA polymerase II, holoenzyme 2.0651E-8 11 56 5 6292
    nucleoplasm part 3.602E-8 11 245 7 6292
    nucleoplasm 6.0476E-8 11 264 7 6292
    macromolecular complex 3.5578E-7 11 1635 11 6292
    nuclear lumen 2.453E-6 11 453 7 6292
    FACT complex 2.779E-6 11 2 2 6292
    organelle lumen 3.0633E-5 11 660 7 6292
    intracellular organelle lumen 3.0633E-5 11 660 7 6292
    membrane-enclosed lumen 4.5212E-5 11 700 7 6292
    alpha DNA polymerase:primase complex 5.8081E-5 11 7 2 6292
    nuclear replisome 4.1874E-4 11 18 2 6292
    replisome 4.1874E-4 11 18 2 6292
    nuclear replication fork 5.1901E-4 11 20 2 6292
    nuclear part 8.5482E-4 11 1103 7 6292
    replication fork 2.3031E-3 11 42 2 6292
    protein-DNA complex 4.2084E-3 11 57 2 6292
    nuclear chromatin 6.8247E-3 11 73 2 6292
    chromatin 7.5696E-3 11 77 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA elongation from RNA polymerase II promoter 6.458E-14 11 39 7 6292
    RNA elongation 1.899E-13 11 45 7 6292
    transcription, DNA-dependent 7.701E-13 11 503 11 6292
    RNA biosynthetic process 8.5956E-13 11 508 11 6292
    transcription 2.1622E-12 11 552 11 6292
    regulation of transcription from RNA polymerase I promoter 5.0581E-12 11 4 4 6292
    histone methylation 8.6263E-11 11 20 5 6292
    regulation of transcription from RNA polymerase III promoter 1.7656E-10 11 7 4 6292
    protein amino acid alkylation 2.3574E-10 11 24 5 6292
    protein amino acid methylation 2.3574E-10 11 24 5 6292
    post-translational protein modification 2.7492E-10 11 357 9 6292
    RNA metabolic process 9.2688E-10 11 954 11 6292
    flocculation via cell wall protein-carbohydrate interaction 1.0565E-9 11 10 4 6292
    flocculation 1.6588E-9 11 11 4 6292
    macromolecule methylation 5.2584E-9 11 43 5 6292
    methylation 5.2584E-9 11 43 5 6292
    protein modification process 5.5202E-9 11 499 9 6292
    cellular macromolecule biosynthetic process 1.0373E-8 11 1187 11 6292
    macromolecule biosynthetic process 1.0568E-8 11 1189 11 6292
    macromolecule modification 1.7764E-8 11 569 9 6292
    one-carbon metabolic process 1.8822E-8 11 55 5 6292
    gene expression 2.4488E-8 11 1283 11 6292
    homeostatic process 4.0603E-8 11 408 8 6292
    nucleic acid metabolic process 7.2197E-8 11 1415 11 6292
    G2/M transition of mitotic cell cycle 1.1748E-7 11 29 4 6292
    transcription from RNA polymerase I promoter 1.3544E-7 11 30 4 6292
    chromatin modification 1.3713E-7 11 168 6 6292
    covalent chromatin modification 2.0643E-7 11 88 5 6292
    histone modification 2.0643E-7 11 88 5 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.2108E-7 11 1566 11 6292
    cellular biosynthetic process 2.2264E-7 11 1567 11 6292
    biosynthetic process 2.841E-7 11 1602 11 6292
    transcription from RNA polymerase II promoter 3.1278E-7 11 335 7 6292
    transcription from RNA polymerase III promoter 3.622E-7 11 38 4 6292
    chromatin organization 4.2312E-7 11 203 6 6292
    regulation of biological quality 4.2867E-7 11 551 8 6292
    cellular nitrogen compound metabolic process 8.537E-7 11 1770 11 6292
    nitrogen compound metabolic process 9.7232E-7 11 1791 11 6292
    G1/S transition of mitotic cell cycle 1.118E-6 11 50 4 6292
    cellular protein metabolic process 4.7266E-6 11 1074 9 6292
    protein metabolic process 7.6839E-6 11 1136 9 6292
    cellular macromolecule metabolic process 1.4269E-5 11 2285 11 6292
    interphase of mitotic cell cycle 1.6126E-5 11 97 4 6292
    interphase 1.6126E-5 11 97 4 6292
    macromolecule metabolic process 1.9349E-5 11 2349 11 6292
    protein amino acid phosphorylation 2.0467E-5 11 103 4 6292
    cellular chemical homeostasis 3.6233E-5 11 119 4 6292
    cellular ion homeostasis 3.6233E-5 11 119 4 6292
    cellular homeostasis 3.7449E-5 11 120 4 6292
    chemical homeostasis 4.1276E-5 11 123 4 6292
    ion homeostasis 4.1276E-5 11 123 4 6292
    multi-organism process 7.4577E-5 11 143 4 6292
    chromosome organization 1.4405E-4 11 555 6 6292
    biological regulation 1.7666E-4 11 1213 8 6292
    phosphorylation 1.7875E-4 11 179 4 6292
    primary metabolic process 1.9438E-4 11 2896 11 6292
    cellular metabolic process 3.2347E-4 11 3033 11 6292
    phosphorus metabolic process 4.6098E-4 11 229 4 6292
    phosphate metabolic process 4.6098E-4 11 229 4 6292
    metabolic process 5.03E-4 11 3157 11 6292
    response to DNA damage stimulus 5.1708E-4 11 236 4 6292
    mitotic cell cycle 6.9404E-4 11 255 4 6292
    anatomical structure homeostasis 1.0703E-3 11 286 4 6292
    telomere organization 1.0703E-3 11 286 4 6292
    telomere maintenance 1.0703E-3 11 286 4 6292
    cellular response to stress 1.1276E-3 11 290 4 6292
    DNA metabolic process 1.9612E-3 11 585 5 6292
    regulation of transcription, DNA-dependent 2.4701E-3 11 358 4 6292
    regulation of RNA metabolic process 2.5996E-3 11 363 4 6292
    transcription initiation from RNA polymerase II promoter 2.8778E-3 11 47 2 6292
    cell cycle phase 2.9585E-3 11 376 4 6292
    cellular response to stimulus 3.046E-3 11 379 4 6292
    regulation of transcription 3.1958E-3 11 384 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.2414E-3 11 415 4 6292
    regulation of nitrogen compound metabolic process 4.2786E-3 11 416 4 6292
    transcription initiation 4.3546E-3 11 58 2 6292
    regulation of gene expression 5.4589E-3 11 445 4 6292
    regulation of macromolecule biosynthetic process 5.9597E-3 11 456 4 6292
    small molecule metabolic process 6.2697E-3 11 760 5 6292
    organelle organization 6.6286E-3 11 1127 6 6292
    regulation of cellular biosynthetic process 6.7432E-3 11 472 4 6292
    regulation of biosynthetic process 6.7944E-3 11 473 4 6292
    regulation of macromolecule metabolic process 7.5943E-3 11 488 4 6292
    cell cycle process 7.7055E-3 11 490 4 6292
    cellular component organization 7.7692E-3 11 1582 7 6292
    response to stress 8.1037E-3 11 497 4 6292
    regulation of primary metabolic process 9.1283E-3 11 514 4 6292
    cell cycle 9.8359E-3 11 525 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase II transcription elongation factor activity 9.1774E-15 11 13 6 6292
    transcription elongation regulator activity 1.4451E-13 11 19 6 6292
    protein kinase CK2 activity 2.779E-6 11 2 2 6292
    protein kinase CK2 regulator activity 2.779E-6 11 2 2 6292
    obsolete_molecular_function 4.1259E-6 11 69 4 6292
    transcription regulator activity 8.5919E-6 11 339 6 6292
    triplex DNA binding 1.7483E-3 11 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle