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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOG2
  • nucleus
  • nucleolus
  • nucleoplasm
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • GTPase activity
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.8756E-17 13 211 12 6292
    nuclear lumen 2.0573E-13 13 453 12 6292
    organelle lumen 1.9073E-11 13 660 12 6292
    intracellular organelle lumen 1.9073E-11 13 660 12 6292
    membrane-enclosed lumen 3.8613E-11 13 700 12 6292
    non-membrane-bounded organelle 1.6587E-9 13 959 12 6292
    intracellular non-membrane-bounded organelle 1.6587E-9 13 959 12 6292
    nuclear part 8.749E-9 13 1103 12 6292
    nucleus 4.29E-7 13 2041 13 6292
    organelle part 4.4049E-5 13 2282 12 6292
    intracellular organelle part 4.4049E-5 13 2282 12 6292
    preribosome, large subunit precursor 1.4073E-4 13 9 2 6292
    nuclear envelope 5.5461E-4 13 199 4 6292
    nuclear outer membrane 6.3872E-4 13 86 3 6292
    nuclear membrane 9.0814E-4 13 97 3 6292
    membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    preribosome 2.13E-3 13 34 2 6292
    intracellular organelle 3.4477E-3 13 4070 13 6292
    organelle 3.4587E-3 13 4071 13 6292
    outer membrane 5.1649E-3 13 178 3 6292
    organelle outer membrane 5.1649E-3 13 178 3 6292
    endomembrane system 7.1331E-3 13 398 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 3.3886E-17 13 346 13 6292
    ribonucleoprotein complex biogenesis 9.4812E-17 13 374 13 6292
    ribosomal large subunit biogenesis 5.2259E-16 13 65 9 6292
    cellular component biogenesis 3.2337E-13 13 694 13 6292
    processing of 27S pre-rRNA 3.8002E-6 13 16 3 6292
    ribosome assembly 6.4995E-6 13 64 4 6292
    organelle assembly 8.7925E-6 13 69 4 6292
    establishment of ribosome localization 1.7434E-5 13 26 3 6292
    ribosome localization 1.7434E-5 13 26 3 6292
    ribosomal subunit export from nucleus 1.7434E-5 13 26 3 6292
    ribonucleoprotein complex assembly 2.7675E-5 13 92 4 6292
    rRNA processing 1.0135E-4 13 128 4 6292
    rRNA metabolic process 1.3204E-4 13 137 4 6292
    establishment of organelle localization 1.6993E-4 13 55 3 6292
    obsolete_biological_process 2.2032E-4 13 60 3 6292
    cellular macromolecular complex assembly 3.9465E-4 13 182 4 6292
    organelle localization 6.1717E-4 13 85 3 6292
    ncRNA processing 7.4339E-4 13 215 4 6292
    nuclear export 1.0815E-3 13 103 3 6292
    ncRNA metabolic process 1.4518E-3 13 257 4 6292
    cellular macromolecular complex subunit organization 1.4943E-3 13 259 4 6292
    macromolecular complex assembly 2.0214E-3 13 281 4 6292
    nuclear transport 2.1181E-3 13 130 3 6292
    nucleocytoplasmic transport 2.1181E-3 13 130 3 6292
    ribosomal large subunit assembly 3.088E-3 13 41 2 6292
    macromolecular complex subunit organization 4.8383E-3 13 357 4 6292
    ribosomal subunit assembly 5.5019E-3 13 55 2 6292
    RNA processing 6.0507E-3 13 380 4 6292
    actomyosin structure organization 6.1865E-3 13 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 6.1865E-3 13 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 6.1865E-3 13 3 1 6292
    cellular component assembly 6.3393E-3 13 385 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 1.4452E-3 13 28 2 6292
    RNA-dependent ATPase activity 1.5505E-3 13 29 2 6292
    ribosomal large subunit binding 2.0661E-3 13 1 1 6292
    7S RNA binding 2.0661E-3 13 1 1 6292
    RNA helicase activity 3.2387E-3 13 42 2 6292
    nucleoside-triphosphatase activity 3.6016E-3 13 329 4 6292
    5S rRNA binding 4.1283E-3 13 2 1 6292
    ATP-dependent helicase activity 4.2134E-3 13 48 2 6292
    purine NTP-dependent helicase activity 4.2134E-3 13 48 2 6292
    hydrolase activity, acting on acid anhydrides 4.646E-3 13 353 4 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.646E-3 13 353 4 6292
    pyrophosphatase activity 4.646E-3 13 353 4 6292
    GTPase activity 6.7329E-3 13 61 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle