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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 14 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
ADA2
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
    		•
  • chromatin modification
  • histone acetylation
    		•
  • transcription coactivator activity
    		•
    GCN5
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
    		•
  • chromatin modification
  • histone acetylation
    		•
  • histone acetyltransferase activity
  • transcription coactivator activity
    		•
    HFI1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
    		•
  • chromatin modification
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • histone acetylation
    		•
  • transcription cofactor activity
  • transcription coactivator activity
    		•
    NGG1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
    		•
  • chromatin modification
  • response to drug
  • histone acetylation
    		•
  • transcription cofactor activity
    		•
    SGF73
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • histone acetylation
    		•
  • histone acetyltransferase activity
  • structural molecule activity
    		•
    SPT3
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • ascospore formation
  • conjugation with cellular fusion
  • pseudohyphal growth
  • histone acetylation
  • invasive growth in response to glucose limitation
    		•
  • transcription cofactor activity
    		•
    SPT7
  • SLIK (SAGA-like) complex
  • mitochondrion
  • SAGA complex
    		•
  • chromatin modification
  • protein complex assembly
  • conjugation with cellular fusion
  • histone acetylation
    		•
  • structural molecule activity
    		•
    SPT8
  • nucleus
  • SAGA complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of transcription from RNA polymerase II promoter
    		•
  • transcription cofactor activity
  • TATA-binding protein binding
    		•
    TAF10
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TAF11
  • transcription factor TFIID complex
    		•
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TAF12
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TAF5
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TAF6
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TAF9
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    SAGA complex 1.81E-33 14 22 13 6292
    SAGA-type complex 4.1625E-33 14 23 13 6292
    SLIK (SAGA-like) complex 2.0799E-32 14 16 12 6292
    histone acetyltransferase complex 1.883E-28 14 44 13 6292
    nucleoplasm part 1.28E-20 14 245 14 6292
    nucleoplasm 3.7444E-20 14 264 14 6292
    nuclear lumen 8.3271E-17 14 453 14 6292
    organelle lumen 1.7241E-14 14 660 14 6292
    intracellular organelle lumen 1.7241E-14 14 660 14 6292
    membrane-enclosed lumen 3.9609E-14 14 700 14 6292
    transcription factor TFIID complex 1.7311E-13 14 15 6 6292
    nuclear part 2.4173E-11 14 1103 14 6292
    protein complex 3.7067E-11 14 1137 14 6292
    Ada2/Gcn5/Ada3 transcription activator complex 7.6616E-11 14 5 4 6292
    DNA-directed RNA polymerase II, holoenzyme 1.0737E-9 14 56 6 6292
    transcription factor complex 4.6587E-9 14 71 6 6292
    macromolecular complex 6.1412E-9 14 1635 14 6292
    nucleus 1.3856E-7 14 2041 14 6292
    organelle part 6.6422E-7 14 2282 14 6292
    intracellular organelle part 6.6422E-7 14 2282 14 6292
    membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone acetylation 1.422E-26 14 36 12 6292
    protein amino acid acetylation 4.4075E-25 14 46 12 6292
    protein amino acid acylation 1.2632E-23 14 59 12 6292
    covalent chromatin modification 2.2975E-21 14 88 12 6292
    histone modification 2.2975E-21 14 88 12 6292
    chromatin modification 7.7099E-18 14 168 12 6292
    chromatin organization 7.9325E-17 14 203 12 6292
    post-translational protein modification 7.6522E-14 14 357 12 6292
    regulation of transcription involved in G1 phase of mitotic cell cycle 1.0398E-13 14 14 6 6292
    protein modification process 4.2949E-12 14 499 12 6292
    G1 phase 1.0105E-11 14 27 6 6292
    G1 phase of mitotic cell cycle 1.0105E-11 14 27 6 6292
    chromosome organization 1.5325E-11 14 555 12 6292
    macromolecule modification 2.0634E-11 14 569 12 6292
    transcription initiation from RNA polymerase II promoter 3.5861E-10 14 47 6 6292
    transcription initiation 1.3355E-9 14 58 6 6292
    protein complex biogenesis 1.4284E-8 14 155 7 6292
    protein complex assembly 1.4284E-8 14 155 7 6292
    interphase of mitotic cell cycle 3.1236E-8 14 97 6 6292
    interphase 3.1236E-8 14 97 6 6292
    cellular protein metabolic process 3.7676E-8 14 1074 12 6292
    organelle organization 6.6117E-8 14 1127 12 6292
    protein metabolic process 7.2543E-8 14 1136 12 6292
    transcription from RNA polymerase II promoter 1.3481E-7 14 335 8 6292
    cellular component organization 1.6627E-7 14 1582 13 6292
    regulation of transcription from RNA polymerase II promoter 2.0689E-7 14 228 7 6292
    cellular macromolecule metabolic process 6.7658E-7 14 2285 14 6292
    macromolecular complex assembly 8.6229E-7 14 281 7 6292
    macromolecule metabolic process 9.9712E-7 14 2349 14 6292
    transcription, DNA-dependent 3.0808E-6 14 503 8 6292
    RNA biosynthetic process 3.3213E-6 14 508 8 6292
    macromolecular complex subunit organization 4.3342E-6 14 357 7 6292
    regulation of transcription, DNA-dependent 4.4161E-6 14 358 7 6292
    regulation of RNA metabolic process 4.8456E-6 14 363 7 6292
    transcription 6.2289E-6 14 552 8 6292
    regulation of transcription 7.0532E-6 14 384 7 6292
    cellular component assembly 7.1765E-6 14 385 7 6292
    mitotic cell cycle 9.5414E-6 14 255 6 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.1814E-5 14 415 7 6292
    regulation of nitrogen compound metabolic process 1.2004E-5 14 416 7 6292
    regulation of gene expression 1.8736E-5 14 445 7 6292
    primary metabolic process 1.8826E-5 14 2896 14 6292
    regulation of macromolecule biosynthetic process 2.2003E-5 14 456 7 6292
    regulation of cellular biosynthetic process 2.7594E-5 14 472 7 6292
    regulation of biosynthetic process 2.7979E-5 14 473 7 6292
    regulation of macromolecule metabolic process 3.4324E-5 14 488 7 6292
    cellular metabolic process 3.6009E-5 14 3033 14 6292
    regulation of primary metabolic process 4.8153E-5 14 514 7 6292
    metabolic process 6.3176E-5 14 3157 14 6292
    regulation of cellular metabolic process 6.3214E-5 14 536 7 6292
    regulation of metabolic process 7.2099E-5 14 547 7 6292
    cell cycle phase 8.7167E-5 14 376 6 6292
    biological regulation 2.8019E-4 14 1213 9 6292
    cellular component biogenesis 3.294E-4 14 694 7 6292
    RNA metabolic process 3.4699E-4 14 954 8 6292
    cell cycle process 3.7814E-4 14 490 6 6292
    cell cycle 5.5047E-4 14 525 6 6292
    regulation of cellular process 7.7405E-4 14 796 7 6292
    regulation of biological process 9.5741E-4 14 824 7 6292
    cellular macromolecule biosynthetic process 1.5934E-3 14 1187 8 6292
    macromolecule biosynthetic process 1.6118E-3 14 1189 8 6292
    gene expression 2.6989E-3 14 1283 8 6292
    nucleic acid metabolic process 5.169E-3 14 1415 8 6292
    cellular process 7.2188E-3 14 4426 14 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.9462E-3 14 1566 8 6292
    cellular biosynthetic process 9.9866E-3 14 1567 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription regulator activity 4.0947E-14 14 339 12 6292
    transcription cofactor activity 1.2918E-10 14 40 6 6292
    transcription factor binding 2.045E-10 14 43 6 6292
    general RNA polymerase II transcription factor activity 2.4576E-9 14 64 6 6292
    RNA polymerase II transcription factor activity 1.8175E-7 14 130 6 6292
    transcription coactivator activity 1.1394E-5 14 21 3 6292
    transcription activator activity 2.9253E-4 14 61 3 6292
    histone acetyltransferase activity 6.135E-4 14 17 2 6292
    lysine N-acetyltransferase activity 6.135E-4 14 17 2 6292
    protein binding 1.2532E-3 14 612 6 6292
    N-acetyltransferase activity 2.3339E-3 14 33 2 6292
    N-acyltransferase activity 3.0877E-3 14 38 2 6292
    TATA-binding protein binding 4.4455E-3 14 2 1 6292
    acetyltransferase activity 5.299E-3 14 50 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle