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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADA2
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • transcription coactivator activity
  • GCN5
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • histone acetyltransferase activity
  • transcription coactivator activity
  • HFI1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • histone acetylation
  • transcription cofactor activity
  • transcription coactivator activity
  • NGG1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • response to drug
  • histone acetylation
  • transcription cofactor activity
  • SGF29
  • SAGA complex
  • histone acetylation
  • molecular_function
  • SGF73
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • histone acetyltransferase activity
  • structural molecule activity
  • SPT20
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • transcription cofactor activity
  • SPT3
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • ascospore formation
  • conjugation with cellular fusion
  • pseudohyphal growth
  • histone acetylation
  • invasive growth in response to glucose limitation
  • transcription cofactor activity
  • SPT7
  • SLIK (SAGA-like) complex
  • mitochondrion
  • SAGA complex
  • chromatin modification
  • protein complex assembly
  • conjugation with cellular fusion
  • histone acetylation
  • structural molecule activity
  • SPT8
  • nucleus
  • SAGA complex
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription cofactor activity
  • TATA-binding protein binding
  • TAF10
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TAF12
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TAF5
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TAF6
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TAF9
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SAGA complex 2.3646E-40 15 22 15 6292
    SAGA-type complex 6.7982E-40 15 23 15 6292
    SLIK (SAGA-like) complex 1.529E-35 15 16 13 6292
    histone acetyltransferase complex 3.1877E-34 15 44 15 6292
    nucleoplasm part 4.7098E-22 15 245 15 6292
    nucleoplasm 1.4911E-21 15 264 15 6292
    nuclear lumen 5.8229E-18 15 453 15 6292
    organelle lumen 1.7741E-15 15 660 15 6292
    intracellular organelle lumen 1.7741E-15 15 660 15 6292
    membrane-enclosed lumen 4.3281E-15 15 700 15 6292
    nuclear part 4.193E-12 15 1103 15 6292
    protein complex 6.6306E-12 15 1137 15 6292
    Ada2/Gcn5/Ada3 transcription activator complex 1.0446E-10 15 5 4 6292
    transcription factor TFIID complex 1.0846E-10 15 15 5 6292
    macromolecular complex 1.5857E-9 15 1635 15 6292
    nucleus 4.4738E-8 15 2041 15 6292
    DNA-directed RNA polymerase II, holoenzyme 1.3064E-7 15 56 5 6292
    organelle part 2.3996E-7 15 2282 15 6292
    intracellular organelle part 2.3996E-7 15 2282 15 6292
    transcription factor complex 4.3647E-7 15 71 5 6292
    membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone acetylation 3.2937E-32 15 36 14 6292
    protein amino acid acetylation 2.0781E-30 15 46 14 6292
    protein amino acid acylation 1.1498E-28 15 59 14 6292
    covalent chromatin modification 5.5371E-26 15 88 14 6292
    histone modification 5.5371E-26 15 88 14 6292
    chromatin modification 7.9762E-22 15 168 14 6292
    chromatin organization 1.2381E-20 15 203 14 6292
    post-translational protein modification 3.9979E-17 15 357 14 6292
    protein modification process 4.5742E-15 15 499 14 6292
    chromosome organization 2.0475E-14 15 555 14 6292
    macromolecule modification 2.9073E-14 15 569 14 6292
    regulation of transcription involved in G1 phase of mitotic cell cycle 7.2404E-11 15 14 5 6292
    cellular protein metabolic process 2.0988E-10 15 1074 14 6292
    organelle organization 4.0974E-10 15 1127 14 6292
    protein metabolic process 4.5756E-10 15 1136 14 6292
    G1 phase 2.8697E-9 15 27 5 6292
    G1 phase of mitotic cell cycle 2.8697E-9 15 27 5 6292
    cellular component organization 4.4453E-8 15 1582 14 6292
    transcription initiation from RNA polymerase II promoter 5.3094E-8 15 47 5 6292
    transcription initiation 1.5629E-7 15 58 5 6292
    cellular macromolecule metabolic process 2.4475E-7 15 2285 15 6292
    macromolecule metabolic process 3.7086E-7 15 2349 15 6292
    protein complex biogenesis 8.4533E-7 15 155 6 6292
    protein complex assembly 8.4533E-7 15 155 6 6292
    interphase of mitotic cell cycle 2.0866E-6 15 97 5 6292
    interphase 2.0866E-6 15 97 5 6292
    transcription from RNA polymerase II promoter 5.0625E-6 15 335 7 6292
    regulation of transcription from RNA polymerase II promoter 8.0653E-6 15 228 6 6292
    primary metabolic process 8.6423E-6 15 2896 15 6292
    cellular metabolic process 1.7316E-5 15 3033 15 6292
    macromolecular complex assembly 2.677E-5 15 281 6 6292
    metabolic process 3.1628E-5 15 3157 15 6292
    transcription, DNA-dependent 7.3048E-5 15 503 7 6292
    RNA biosynthetic process 7.7854E-5 15 508 7 6292
    macromolecular complex subunit organization 1.0337E-4 15 357 6 6292
    regulation of transcription, DNA-dependent 1.05E-4 15 358 6 6292
    regulation of RNA metabolic process 1.1345E-4 15 363 6 6292
    transcription 1.3259E-4 15 552 7 6292
    regulation of transcription 1.5512E-4 15 384 6 6292
    cellular component assembly 1.5738E-4 15 385 6 6292
    mitotic cell cycle 2.2599E-4 15 255 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.3821E-4 15 415 6 6292
    regulation of nitrogen compound metabolic process 2.4139E-4 15 416 6 6292
    regulation of gene expression 3.4924E-4 15 445 6 6292
    regulation of macromolecule biosynthetic process 3.9896E-4 15 456 6 6292
    regulation of cellular biosynthetic process 4.8117E-4 15 472 6 6292
    regulation of biosynthetic process 4.8672E-4 15 473 6 6292
    regulation of macromolecule metabolic process 5.7625E-4 15 488 6 6292
    regulation of primary metabolic process 7.6188E-4 15 514 6 6292
    regulation of cellular metabolic process 9.5318E-4 15 536 6 6292
    regulation of metabolic process 1.062E-3 15 547 6 6292
    cell cycle phase 1.3522E-3 15 376 5 6292
    biological regulation 3.294E-3 15 1213 8 6292
    cellular component biogenesis 3.6715E-3 15 694 6 6292
    RNA metabolic process 3.7928E-3 15 954 7 6292
    cell cycle process 4.369E-3 15 490 5 6292
    cellular process 5.0732E-3 15 4426 15 6292
    cell cycle 5.8835E-3 15 525 5 6292
    regulation of cellular process 7.3152E-3 15 796 6 6292
    regulation of biological process 8.6743E-3 15 824 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription regulator activity 1.949E-13 15 339 12 6292
    transcription cofactor activity 1.4977E-12 15 40 7 6292
    transcription factor binding 2.5801E-12 15 43 7 6292
    general RNA polymerase II transcription factor activity 2.58E-7 15 64 5 6292
    RNA polymerase II transcription factor activity 8.867E-6 15 130 5 6292
    transcription coactivator activity 1.4212E-5 15 21 3 6292
    protein binding 2.5504E-4 15 612 7 6292
    transcription activator activity 3.6315E-4 15 61 3 6292
    histone acetyltransferase activity 7.0676E-4 15 17 2 6292
    lysine N-acetyltransferase activity 7.0676E-4 15 17 2 6292
    N-acetyltransferase activity 2.6841E-3 15 33 2 6292
    N-acyltransferase activity 3.5492E-3 15 38 2 6292
    TATA-binding protein binding 4.7627E-3 15 2 1 6292
    acetyltransferase activity 6.0833E-3 15 50 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle