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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
FUN12
  • mitochondrion
  • translational initiation
  • translation initiation factor activity
  • GTPase activity
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • RPL15A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL20B
  • ribosome biogenesis
  • translation
  • structural constituent of ribosome
  • RPS11A, RPS11B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPS1B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS4B, RPS4A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPS6A, RPS6B
  • small-subunit processome
  • nucleus
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • nucleolus
  • 90S preribosome
  • intracellular
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • translation
  • structural constituent of ribosome
  • RPS7A
  • small nucleolar ribonucleoprotein complex
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • STM1
  • cytoplasm
  • nuclear telomere cap complex
  • anti-apoptosis
  • telomere maintenance
  • DNA binding
  • telomeric DNA binding
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    90S preribosome 5.9069E-11 12 17 5 6292
    preribosome 2.6145E-9 12 34 5 6292
    cytosolic small ribosomal subunit 4.6987E-9 12 38 5 6292
    cytosolic ribosome 1.2596E-8 12 101 6 6292
    cytosolic part 3.9481E-8 12 122 6 6292
    small ribosomal subunit 1.3609E-7 12 73 5 6292
    ribosomal subunit 4.4578E-7 12 183 6 6292
    ribonucleoprotein complex 6.9393E-7 12 514 8 6292
    cytosol 5.8922E-6 12 284 6 6292
    non-membrane-bounded organelle 6.103E-6 12 959 9 6292
    intracellular non-membrane-bounded organelle 6.103E-6 12 959 9 6292
    ribosome 6.6531E-6 12 290 6 6292
    macromolecular complex 5.2917E-4 12 1635 9 6292
    nucleolus 6.5368E-3 12 211 3 6292
    intracellular organelle part 7.3047E-3 12 2282 9 6292
    organelle part 7.3047E-3 12 2282 9 6292
    small nucleolar ribonucleoprotein complex 7.9142E-3 12 72 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 1.6606E-9 12 376 9 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 5.3753E-9 12 13 4 6292
    maturation of SSU-rRNA 3.2646E-6 12 59 4 6292
    gene expression 5.3098E-6 12 1283 10 6292
    cellular protein metabolic process 1.6032E-5 12 1074 9 6292
    ribosome biogenesis 1.8454E-5 12 346 6 6292
    protein metabolic process 2.5792E-5 12 1136 9 6292
    ribonucleoprotein complex biogenesis 2.8833E-5 12 374 6 6292
    cellular macromolecule biosynthetic process 3.7358E-5 12 1187 9 6292
    macromolecule biosynthetic process 3.7891E-5 12 1189 9 6292
    rRNA processing 7.1288E-5 12 128 4 6292
    rRNA metabolic process 9.2981E-5 12 137 4 6292
    cellular macromolecule metabolic process 1.144E-4 12 2285 11 6292
    regulation of translation 1.4638E-4 12 57 3 6292
    macromolecule metabolic process 1.5296E-4 12 2349 11 6292
    posttranscriptional regulation of gene expression 1.7927E-4 12 61 3 6292
    regulation of cellular protein metabolic process 2.4776E-4 12 68 3 6292
    regulation of protein metabolic process 3.184E-4 12 74 3 6292
    cellular biosynthetic process 3.745E-4 12 1567 9 6292
    biosynthetic process 4.4838E-4 12 1602 9 6292
    ncRNA processing 5.2873E-4 12 215 4 6292
    cellular component biogenesis 9.0662E-4 12 694 6 6292
    ncRNA metabolic process 1.0381E-3 12 257 4 6292
    primary metabolic process 1.3504E-3 12 2896 11 6292
    negative regulation of programmed cell death 1.9072E-3 12 1 1 6292
    anti-apoptosis 1.9072E-3 12 1 1 6292
    negative regulation of cell death 1.9072E-3 12 1 1 6292
    negative regulation of apoptosis 1.9072E-3 12 1 1 6292
    cellular metabolic process 2.1697E-3 12 3033 11 6292
    metabolic process 3.2647E-3 12 3157 11 6292
    RNA processing 4.3958E-3 12 380 4 6292
    regulation of programmed cell death 7.6087E-3 12 4 1 6292
    regulation of apoptosis 7.6087E-3 12 4 1 6292
    regulation of cell death 7.6087E-3 12 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 6.4272E-10 12 212 8 6292
    structural molecule activity 2.6819E-8 12 339 8 6292
    rRNA binding 3.9428E-4 12 16 2 6292
    nucleic acid binding 7.2534E-4 12 666 6 6292
    RNA binding 3.8749E-3 12 367 4 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle