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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
FUN12
  • mitochondrion
  • translational initiation
  • translation initiation factor activity
  • GTPase activity
  • IMD3
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • RPL15A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL4B
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL5
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPP0
  • ribosomal large subunit assembly
  • translational elongation
  • translation
  • structural constituent of ribosome
  • RPS1B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS3
  • preribosome, small subunit precursor
  • response to DNA damage stimulus
  • translation
  • structural constituent of ribosome
  • RPS4B, RPS4A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • STM1
  • cytoplasm
  • nuclear telomere cap complex
  • anti-apoptosis
  • telomere maintenance
  • DNA binding
  • telomeric DNA binding
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    preribosome 2.31E-5 11 34 3 6292
    90S preribosome 3.7257E-4 11 17 2 6292
    cytosolic ribosome 6.033E-4 11 101 3 6292
    cytosolic part 1.0475E-3 11 122 3 6292
    ribonucleoprotein complex 1.088E-3 11 514 5 6292
    cytosolic small ribosomal subunit 1.8876E-3 11 38 2 6292
    ribosomal subunit 3.3612E-3 11 183 3 6292
    small ribosomal subunit 6.8247E-3 11 73 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.1303E-8 11 376 8 6292
    gene expression 2.1916E-5 11 1283 9 6292
    cellular protein metabolic process 7.1339E-5 11 1074 8 6292
    protein metabolic process 1.0851E-4 11 1136 8 6292
    cellular biosynthetic process 1.2033E-4 11 1567 9 6292
    biosynthetic process 1.4499E-4 11 1602 9 6292
    cellular macromolecule biosynthetic process 1.5044E-4 11 1187 8 6292
    macromolecule biosynthetic process 1.5233E-4 11 1189 8 6292
    primary metabolic process 1.9438E-4 11 2896 11 6292
    cellular macromolecule metabolic process 2.9073E-4 11 2285 10 6292
    cellular metabolic process 3.2347E-4 11 3033 11 6292
    macromolecule metabolic process 3.7814E-4 11 2349 10 6292
    metabolic process 5.03E-4 11 3157 11 6292
    negative regulation of programmed cell death 1.7483E-3 11 1 1 6292
    negative regulation of cell death 1.7483E-3 11 1 1 6292
    anti-apoptosis 1.7483E-3 11 1 1 6292
    negative regulation of apoptosis 1.7483E-3 11 1 1 6292
    ribosomal large subunit assembly 2.1955E-3 11 41 2 6292
    GTP biosynthetic process 3.4937E-3 11 2 1 6292
    ribosomal subunit assembly 3.9232E-3 11 55 2 6292
    ribosome assembly 5.2805E-3 11 64 2 6292
    ribosomal large subunit biogenesis 5.443E-3 11 65 2 6292
    organelle assembly 6.1157E-3 11 69 2 6292
    regulation of programmed cell death 6.9763E-3 11 4 1 6292
    regulation of cell death 6.9763E-3 11 4 1 6292
    regulation of apoptosis 6.9763E-3 11 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 1.3154E-8 11 212 7 6292
    structural molecule activity 3.3934E-7 11 339 7 6292
    nucleic acid binding 3.9815E-4 11 666 6 6292
    RNA binding 2.7066E-3 11 367 4 6292
    IMP dehydrogenase activity 5.2364E-3 11 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle