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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC40
  • spliceosomal complex
  • nuclear mRNA branch site recognition
  • nuclear mRNA 3'-splice site recognition
  • second spliceosomal transesterification activity
  • CLF1
  • chromatin
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC22
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • PRP45
  • nucleus
  • spliceosomal complex
  • positive regulation of transcription from RNA polymerase II promoter
  • nuclear mRNA splicing, via spliceosome
  • transcription activator activity
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SNT309
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SYF1
  • spliceosomal complex
  • cell cycle
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    spliceosomal complex 1.7226E-15 12 45 8 6292
    ribonucleoprotein complex 1.0889E-11 12 514 11 6292
    nuclear part 4.6507E-8 12 1103 11 6292
    macromolecular complex 3.2574E-6 12 1635 11 6292
    organelle part 5.0851E-6 12 2282 12 6292
    intracellular organelle part 5.0851E-6 12 2282 12 6292
    nucleus 3.4695E-5 12 2041 11 6292
    small nuclear ribonucleoprotein complex 1.9738E-4 12 63 3 6292
    U2 snRNP 2.571E-4 12 13 2 6292
    intracellular organelle 5.3355E-3 12 4070 12 6292
    organelle 5.3513E-3 12 4071 12 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 1.1622E-22 12 99 12 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.3207E-22 12 100 12 6292
    RNA splicing, via transesterification reactions 3.1165E-22 12 107 12 6292
    RNA splicing 4.3877E-21 12 132 12 6292
    mRNA processing 3.5331E-20 12 156 12 6292
    mRNA metabolic process 1.6695E-18 12 213 12 6292
    RNA processing 1.9966E-15 12 380 12 6292
    RNA metabolic process 1.3916E-10 12 954 12 6292
    gene expression 4.9591E-9 12 1283 12 6292
    nucleic acid metabolic process 1.6138E-8 12 1415 12 6292
    spliceosome assembly 2.2888E-8 12 18 4 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.4733E-8 12 1566 12 6292
    cellular nitrogen compound metabolic process 2.3908E-7 12 1770 12 6292
    nitrogen compound metabolic process 2.7555E-7 12 1791 12 6292
    ribonucleoprotein complex assembly 4.377E-7 12 92 5 6292
    cellular macromolecule metabolic process 5.1661E-6 12 2285 12 6292
    macromolecule metabolic process 7.2022E-6 12 2349 12 6292
    cellular macromolecular complex assembly 1.2874E-5 12 182 5 6292
    cellular macromolecular complex subunit organization 7.1002E-5 12 259 5 6292
    primary metabolic process 8.9282E-5 12 2896 12 6292
    macromolecular complex assembly 1.0483E-4 12 281 5 6292
    cellular metabolic process 1.5563E-4 12 3033 12 6292
    metabolic process 2.5194E-4 12 3157 12 6292
    macromolecular complex subunit organization 3.2502E-4 12 357 5 6292
    ribonucleoprotein complex biogenesis 4.0398E-4 12 374 5 6292
    cellular component assembly 4.624E-4 12 385 5 6292
    nuclear mRNA 3'-splice site recognition 3.811E-3 12 2 1 6292
    cis assembly of pre-catalytic spliceosome 3.811E-3 12 2 1 6292
    nuclear mRNA cis splicing, via spliceosome 5.7116E-3 12 3 1 6292
    generation of catalytic spliceosome for first transesterification step 5.7116E-3 12 3 1 6292
    nuclear mRNA branch site recognition 5.7116E-3 12 3 1 6292
    cellular component biogenesis 6.5683E-3 12 694 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    snRNA binding 3.3242E-5 12 5 2 6292
    U2 snRNA binding 1.9072E-3 12 1 1 6292
    U5 snRNA binding 3.811E-3 12 2 1 6292
    RNA binding 3.8749E-3 12 367 4 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle