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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BUD31
  • nucleus
  • RNA splicing
  • cellular bud site selection
  • molecular_function
  • CLF1
  • chromatin
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC22
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC23
  • spliceosomal complex
  • biological_process
  • molecular_function
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SNT309
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SYF1
  • spliceosomal complex
  • cell cycle
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    spliceosomal complex 1.7226E-15 12 45 8 6292
    ribonucleoprotein complex 6.9243E-10 12 514 10 6292
    nuclear part 1.2397E-6 12 1103 10 6292
    nucleus 3.4695E-5 12 2041 11 6292
    macromolecular complex 5.3141E-5 12 1635 10 6292
    organelle part 1.1283E-4 12 2282 11 6292
    intracellular organelle part 1.1283E-4 12 2282 11 6292
    intracellular organelle 5.3355E-3 12 4070 12 6292
    organelle 5.3513E-3 12 4071 12 6292
    small nuclear ribonucleoprotein complex 6.105E-3 12 63 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA splicing 7.4695E-16 12 132 10 6292
    nuclear mRNA splicing, via spliceosome 8.6491E-15 12 99 9 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9.5004E-15 12 100 9 6292
    RNA splicing, via transesterification reactions 1.7852E-14 12 107 9 6292
    RNA processing 3.8587E-13 12 380 11 6292
    mRNA processing 5.8092E-13 12 156 9 6292
    mRNA metabolic process 9.9585E-12 12 213 9 6292
    RNA metabolic process 9.5918E-9 12 954 11 6292
    gene expression 2.393E-7 12 1283 11 6292
    nucleic acid metabolic process 6.8885E-7 12 1415 11 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0509E-6 12 1566 11 6292
    cellular nitrogen compound metabolic process 7.6146E-6 12 1770 11 6292
    nitrogen compound metabolic process 8.6368E-6 12 1791 11 6292
    cellular macromolecule metabolic process 1.144E-4 12 2285 11 6292
    macromolecule metabolic process 1.5296E-4 12 2349 11 6292
    spliceosome assembly 5.0164E-4 12 18 2 6292
    ribonucleoprotein complex assembly 6.0496E-4 12 92 3 6292
    primary metabolic process 1.3504E-3 12 2896 11 6292
    cellular metabolic process 2.1697E-3 12 3033 11 6292
    metabolic process 3.2647E-3 12 3157 11 6292
    cis assembly of pre-catalytic spliceosome 3.811E-3 12 2 1 6292
    ribonucleoprotein complex biogenesis 4.1497E-3 12 374 4 6292
    cellular macromolecular complex assembly 4.3192E-3 12 182 3 6292
    nuclear mRNA cis splicing, via spliceosome 5.7116E-3 12 3 1 6292
    generation of catalytic spliceosome for first transesterification step 5.7116E-3 12 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    snRNA binding 3.3242E-5 12 5 2 6292
    U2 snRNA binding 1.9072E-3 12 1 1 6292
    U5 snRNA binding 3.811E-3 12 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle