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Protein Overview: PUT2

General Information:
Name(s) found: PUT2 / YHR037W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 575 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Biological Process: glutamate biosynthetic process [TASLink to PubMed article]
    proline catabolic process [TASLink to PubMed article]
    proline catabolic process to glutamate [IMPLink to PubMed article]
    Molecular Function: 1-pyrroline-5-carboxylate dehydrogenase activity [IMPLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSARCLKSI YFKRSFSQLG HIKPPKHIRN EPVKPFRNID LKDWDLLRAS LMKFKSSSLE  60
   61 VPLVINGERI YDNNERALFP QTNPANHQQV LANVTQATEK DVMNAVKAAK DAKKDWYNLP 120
  121 FYDRSAIFLK AADLISTKYR YDMLAATMLG QGKNVYQAEI DCITELSDFF RYYVKYASDL 180
  181 YAQQPVESAD GTWNKAEYRP LEGFVYAVSP FNFTAIAANL IGAPALMGNT VVWKPSQTAA 240
  241 LSNYLLMTVL EEAGLPKGVI NFIPGDPVQV TDQVLADKDF GALHFTGSTN VFKSLYGKIQ 300
  301 SGVVEGKYRD YPRIIGETGG KNFHLVHPSA NISHAVLSTI RGTFEFQGQK CSAASRLYLP 360
  361 ESKSEEFLSD MFGILQSQNV VPMNTSASPI SGGNLRGFMG PVIHEQSFDK LVKVIEDAKK 420
  421 DPELEILYGG QYDKSQGWFV GPTVIKAKRP DHPYMSTEFF GPILTVYEYP DTEFNEICDI 480
  481 IDNTSQYALT GAIFAKDRKA IEYADEKLKF SAGNFYINDK CTGAVVSQQW FGGARMSGTD 540
  541 DKAGGPNILS RFVSIRNTKE NFYELTDFKY PSNYE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PUT2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..318]
    [525..575]    		 PSI-BLAST 1366.9897 Aldehyde reductase (dehydrogenase), ALDH
    2 View Details [319..524] PSI-BLAST 1366.9897 Aldehyde reductase (dehydrogenase), ALDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  5.09598561374689 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  4.35175408702761 bayes_pls_golite062009
  • malonate-semialdehyde dehydrogenase (acetylating) activity
    		•  4.2273960318884 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  3.87605237828483 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  3.27180265380824 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  2.99564252244797 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  2.70230501280821 bayes_pls_golite062009
  • aldehyde dehydrogenase [NAD(P)+] activity
    		•  2.43250909158896 bayes_pls_golite062009
  • aminobutyraldehyde dehydrogenase activity
    		•  2.35958138496479 bayes_pls_golite062009
  • acyl-CoA binding
    		•  2.26220696569489 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  1.6559690223037 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  1.42867174920845 bayes_pls_golite062009
  • binding
    		•  1.06673666884196 bayes_pls_golite062009
  • retinoid binding
    		•  0.983782635681687 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.900374761028287 bayes_pls_golite062009
  • protein binding
    		•  0.894945263794726 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.258030369394064 bayes_pls_golite062009
  • benzaldehyde dehydrogenase (NAD+) activity
    		•  0.23487570676521 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle