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Protein Overview: PROF1_RAT

General Information:
Name(s) found: PROF1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|51702769|sp|P62963.2|PROF1_RAT RecName: Full=Profilin-1; AltName: Full=Profilin I [NCBI NR]
  • gi|42476144|ref|NP_071956.2| profilin 1 [Rattus norvegicus] [NCBI NR]
  • gi|38382852|gb|AAH62405.1| Profilin 1 [Rattus norvegicus] [NCBI NR]
  • gi|149053223|gb|EDM05040.1| profilin 1, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149053222|gb|EDM05039.1| profilin 1, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149053218|gb|EDM05035.1| profilin 1, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • Profilin-1 OS=Rattus norvegicus GN=Pfn1 PE=1 SV=2 [Swiss-Prot]
  • profilin [HMR_022704-rand.fasta]
  • profilin 1 [Rattus norvegicus]gi|6755040|ref|NP_035202.1| profilin 1 [Mus musculus]gi|38382852|gb|AAH62405.1| Profilin 1 [Rattus norvegicus]gi|12805237|gb|AAH02080.1| Profilin 1 [Mus musculus]gi|91197|pir||S04067 profilin - mousegi|53782|emb|CAA32586 [nrdb_11152004_Chlamydomonas]
  • Profilin-1 (Profilin I) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • profilin 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • profilin 1, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Profilin 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 PROFILIN 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Pfn1 Profilin-1 [rat-ipi-250309-contam.fasta]
  • Profilin-1 OS=Rattus norvegicus GN=Pfn1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 140 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    synaptosome [IDA]
    cytoplasm [UNKNOWN][IDA][TAS]
    actin cytoskeleton [IEA]
    synapse [IDA]
    Biological Process: response to organic substance [IEP]
    neural tube closure [UNKNOWN][IEA]
    actin polymerization or depolymerization [TAS]
    positive regulation of stress fiber assembly [IMP]
    cellular response to growth factor stimulus [IEP]
    positive regulation of DNA metabolic process [IDA]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    actin cytoskeleton organization [IEA]
    positive regulation of viral transcription [IMP]
    regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    Molecular Function: phosphatidylinositol-4,5-bisphosphate binding [IDA]
    proline-rich region binding [UNKNOWN][IEA]
    protein binding [UNKNOWN][IPI]
    actin binding [UNKNOWN][TAS]
    Rho GTPase binding [IEA]
    receptor binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGWNAYIDS LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VSITPAEVGV LVGKDRSSFF  60
   61 VNGLTLGGQK CSVIRDSLLQ DGEFTMDLRT KSTGGAPTFN VTVTMTAKTL VLLMGKEGVH 120
  121 GGLINKKCYE MASHLRRSQY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] PSI-BLAST 50.0 Profilin (actin-binding protein)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  7.981958446142 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.51470611165788 bayes_pls_golite062009
  • actin monomer binding
    		•  3.80837480536839 bayes_pls_golite062009
  • binding
    		•  3.26636517628678 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  3.08913463974786 bayes_pls_golite062009
  • protein binding
    		•  2.14534188091242 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle