Protein Overview: HMDH_RAT

General Information:
Name(s) found:	HMDH_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|40538852\|ref\|NP_037266.2\| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Rattus norvegicus] [NCBI NR] gi\|40352928\|gb\|AAH64654.1\| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Rattus norvegicus] [NCBI NR] gi\|149059113\|gb\|EDM10120.1\| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Rattus norvegicus] [NCBI NR] gi\|118573791\|sp\|P51639.2\|HMDH_RAT RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase [NCBI NR] 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Rattus norvegicus GN=Hmgcr PE=1 SV=2 [Swiss-Prot] 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [HMR_022704-rand.fasta] 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Rattus norvegicus]gi\|40352928\|gb\|AAH64654.1\| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Hmgcr 3-hydroxy-3-methylglutaryl-coenzyme A reductase [rat-ipi-250309-contam.fasta] 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Rattus norvegicus GN=Hmgcr [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	887 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [UNKNOWN][IEA] membrane [IEA] microsome [UNKNOWN][IDA] integral to membrane [IEA] endoplasmic reticulum [IEA]
Biological Process:	embryonic development [UNKNOWN][IEA] farnesyl diphosphate biosynthetic process, mevalonate pathway [TAS] negative regulation of MAP kinase activity [UNKNOWN][IEA] positive regulation of skeletal muscle tissue development [IMP] cholesterol biosynthetic process [UNKNOWN][IDA] coenzyme A metabolic process [IEA] response to nutrient [IEP] visual learning [UNKNOWN][IEA] oxidation reduction [IEA] isoprenoid biosynthetic process [IDA] aging [IEP]
Molecular Function:	NADP or NADPH binding [IEA] protein homodimerization activity [IDA] hydroxymethylglutaryl-CoA reductase activity [IDA] oxidoreductase activity [IEA] hydroxymethylglutaryl-CoA reductase (NADPH) activity [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS  60
   61 DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG 120
  121 LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG 180
  181 VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR 240
  241 VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTAEQSKVS LGLAEDVSKR 300
  301 IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QAETESTLSL KNPITSPVVT 360
  361 PKKAQDNCCR REPLLVRRNQ KLSSVEEDPG VNQDRKVEVI KPLVAEAETS GRATFVLGAS 420
  421 AASPPLALGA QEPGIELPSE PRPNEECLQI LESAEKGAKF LSDAEIIQLV NAKHIPAYKL 480
  481 ETLMETHERG VSIRRQLLSA KLAEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA 540
  541 GPLCLDGKEY QVPMATTEGC LVASTNRGCR AISLGGGASS RVLADGMSRG PVVRLPRACD 600
  601 SAEVKSWLET PEGFAVVKEA FDSTSRFARL QKLHVTLAGR NLYIRLQSKT GDAMGMNMIS 660
  661 KGTEKALLKL QEFFPELQIL AVSGNYCTDK KPAAINWIEG RGKTVVCEAV IPAKVVREVL 720
  721 KTTTEAMVDV NINKNLVGSA MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM 780
  781 EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQML GVQGACKDNP GENARQLARI 840
  841 VCGTVMAGEL SLMAALAAGH LVRSHMVHNR SKINLQDLQG TCTKKAA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: HMDH_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: