Protein Overview: SH2B2_RAT

General Information:
Name(s) found:	SH2B2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|62286455\|sp\|Q9Z200.1\|SH2B2_RAT RecName: Full=SH2B adapter protein 2; AltName: Full=SH2 and PH domain-containing adapter protein APS; AltName: Full=Adapter protein with pleckstrin homology and Src homology 2 domains [NCBI NR] gi\|3766234\|gb\|AAC64408.1\| APS protein [Rattus norvegicus] [NCBI NR] gi\|16758940\|ref\|NP_446121.1\| SH2B adaptor protein 2 [Rattus norvegicus] [NCBI NR] gi\|149062992\|gb\|EDM13315.1\| adaptor protein with pleckstrin homology and src homology 2 domains, isoform CRA_a [Rattus norvegicus] [NCBI NR] SH2B adapter protein 2 OS=Rattus norvegicus GN=Sh2b2 PE=1 SV=1 [Swiss-Prot] (Q9Z200) SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains) [Swiss-Prot] adaptor protein with pleckstrin homology and src homology 2 domains [HMR_022704-rand.fasta] adaptor protein with pleckstrin homology and src homology 2 domains [Rattus norvegicus]gi\|3766234\|gb\|AAC64408.1\| APS protein [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] (NM_053669) adaptor protein with pleckstrin homology and src homology 2 domains [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] SH2B adapter protein 2 (SH2 and PH domain-containing adapter protein APS) (Adapter protein with pleckstrin homology and Src homology 2 domains) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] SH2B adaptor protein 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] adaptor protein with pleckstrin homology and src homology 2 domains, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] APS protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] adaptor protein with pleckstrin homology and src homology 2 domains [Rattus norvegicus] [nr-271106-contam.fasta] SH2B adapter protein 2 OS=Rattus norvegicus GN=Sh2b2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	621 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [UNKNOWN][IEA] stress fiber [UNKNOWN][IEA] ruffle [UNKNOWN][IEA] actin filament [UNKNOWN][IEA] plasma membrane [UNKNOWN][IEA]
Biological Process:	antigen receptor-mediated signaling pathway [UNKNOWN][IEA] brown fat cell differentiation [UNKNOWN][IEA] intracellular signaling pathway [UNKNOWN][IEA] insulin receptor signaling pathway [UNKNOWN][IEA] B-1 B cell homeostasis [UNKNOWN][IEA] cytokine-mediated signaling pathway [UNKNOWN][IEA] nervous system development [IMP] regulation of Ras protein signal transduction [IDA] regulation of metabolic process [UNKNOWN][IEA] actin cytoskeleton organization [UNKNOWN][IEA] regulation of immune response [UNKNOWN][IEA]
Molecular Function:	SH3/SH2 adaptor activity [UNKNOWN][IEA] protein binding [UNKNOWN][IEA] JAK pathway signal transduction adaptor activity [UNKNOWN][IEA] transmembrane receptor protein tyrosine kinase adaptor protein activity [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGATPGSAA APAPVPDWRQ FCELHAQVAA VDFAHKFCRF LRDNPTYDTP DAGTSFSRHF  60
   61 AANFLAVFSE EVRRVLGTAA DTMEPEPAVT SVTSALKTAT YGHSRSSEDV SAHVATKARV 120
  121 RKGFSLRNMS LCVVDGVRDL WHRRASPEPE GGATPKTTEP VSEPRDKWTR RLRLARTLAA 180
  181 KVELVDIQRE GALRFMVADD AASGPGGTAQ WQKCRLLLRR AVAGERFRLE FFVPPKASRP 240
  241 KVSIPLSAII EVRTTMPLEM PEKDNTFVLK VENGAEYILE TIDSLQKHSW VADIQGCVDP 300
  301 GDSEEDTGLS CARGGCLASR VTSCSCELLT EADMPRPPET MTAVGAVVTA PHGRARDTVG 360
  361 ESLAHVPLET FLQTLESSGG VSESNNTGDE GAELDPDAEA ELELSDYPWF HGTLSRVKAA 420
  421 QLVLAGGPRS HGLFVIRQSE TRPGECVLTF NFQGKAKHLR LSLNGHGQCH VQHLWFQSVF 480
  481 DMLRHFHTHP IPLESGGSAD ITLRSYVRAQ GPPPDPGPAP NTAAPVPACW TEPAGQHYFS 540
  541 SLATATCPPT SPSNGAGASS SSGSSSSATS VPPRPAEGPL SARSRSNSTE HLLEAASGAT 600
  601 EEPADATLGR ARAVENQYSF Y

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: SH2B2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: