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Protein Overview: GPX2_MOUSE

General Information:
Name(s) found: GPX2_MOUSE [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Glutathione peroxidase 2 OS=Mus musculus GN=Gpx2 PE=2 SV=3 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 190 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    cytosol [TAS]
    Biological Process: negative regulation of inflammatory response to antigenic stimulus [IGI]
    response to oxidative stress [IEA]
    temperature homeostasis [IGI]
    response to symbiotic bacterium [IGI]
    oxidation reduction [IEA]
    interaction with symbiont [IGI]
    Molecular Function: peroxidase activity [IEA]
    glutathione peroxidase activity [UNKNOWN][IMP][ISS]
    oxidoreductase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYIAKSFYD LSAIGLDGEK IDFNTFRGRA VLIENVASLU GTTTRDYNQL NELQCRFPRR  60
   61 LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFS LTQKCDVNGQ NEHPVFAYLK 120
  121 DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV SWNFEKFLIG PEGEPFRRYS RSFQTINIEP 180
  181 DIKRLLKVAI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] PSI-BLAST 51.69897 Glutathione peroxidase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • selenium binding
    		•  3.88074839847028 bayes_pls_golite062009
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • glutathione binding
    		•  3.70571520983029 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  3.34867897786732 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  3.27312030654855 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  3.14026319569721 bayes_pls_golite062009
  • glutathione transferase activity
    		•  3.10261229787796 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  2.66666794593609 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.5141654924344 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.84647221968732 bayes_pls_golite062009
  • proteasome inhibitor activity
    		•  1.80247749812127 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • hydrolase activity
    		•  1.04103775676964 bayes_pls_golite062009
  • phospholipid-hydroperoxide glutathione peroxidase activity
    		•  0.874146425427531 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • signal transducer activity
    		•  0.588857285491299 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.588857285491299 bayes_pls_golite062009
  • transferase activity
    		•  0.245320538630117 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle