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Protein Overview: SMUG1_MOUSE

General Information:
Name(s) found: SMUG1_MOUSE [Swiss-Prot]
Description(s) found:
Found 22 descriptions.
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  • Single-strand selective monofunctional uracil DNA glycosylase OS=Mus musculus GN=Smug1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 279 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    soluble fraction [UNKNOWN]
    nucleolus [ISS]
    Biological Process: DNA repair [UNKNOWN]
    base-excision repair [UNKNOWN][ISS]
    metabolic process [IEA]
    response to DNA damage stimulus [IEA]
    Molecular Function: DNA binding [IEA]
    uracil DNA N-glycosylase activity [UNKNOWN][ISS]
    single-strand selective uracil DNA N-glycosylase activity [UNKNOWN][ISS]
    oxidized base lesion DNA N-glycosylase activity [UNKNOWN]
    DNA N-glycosylase activity [ISS]
    hydrolase activity [IEA]
    hydrolase activity, acting on glycosyl bonds [IEA]
    single-stranded DNA binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAASQTFPLG PTHEPASALM EPLPCTRSLA EGFLEEELRL NAELSQLQFP EPVGVIYNPV  60
   61 DYAWEPHRNY VTRYCQGPKE VLFLGMNPGP FGMAQTGVPF GEVNVVRDWL GVGGPVLTPP 120
  121 QEHPKRPVLG LECPQSEVSG ARFWGFFRTL CGQPQVFFRH CFVHNLCPLL FLAPSGRNLT 180
  181 PAELPAKQRE QLLSICDAAL CRQVQLLGVR LVVGVGRLAE QRARRALAGL TPEVQVEGLL 240
  241 HPSPRSAQAN KGWEAAARER LQELGLLPLL TDEGSARPT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..279] PSI-BLAST 120.0 Single-strand selective monofunctional uracil-DNA glycosylase SMUG1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  5.22461096584694 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  4.68115068202636 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  4.48822773983461 bayes_pls_golite062009
  • single-strand selective uracil DNA N-glycosylase activity
    		•  3.83194769747125 bayes_pls_golite062009
  • hydrolase activity
    		•  2.80752243868997 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.59556365302624 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.75635693402802 bayes_pls_golite062009
  • catalytic activity
    		•  1.59111295908728 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  1.34999321643757 bayes_pls_golite062009
  • binding
    		•  1.2276262882727 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.14199628308287 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.901890891144085 bayes_pls_golite062009
  • DNA binding
    		•  0.850361767185031 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.543168797464517 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.44704532195099 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.307323249123648 bayes_pls_golite062009
  • protein binding
    		•  0.272261244770552 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle