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Protein Overview: rnh1-PB

General Information:
Name(s) found: rnh1-PB / FBpp0089188 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene ribonuclease H1 is referred to in FlyBase by the symbol Dmel\rnh1 (CG8729, FBgn0023171). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3818530..3819891. It has the cytological map location 43F2. There is experimental evidence that it has the molecular function</span>: ribonuclease H activity. The biological processes in which it is involved are not known. 8 alleles are reported. The phenotypes of these alleles are annotated with: stage P4(ii) prepupa; melanotic mass; larval central nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 314 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: nucleic acid binding [IEA]
    magnesium ion binding [IEA]
    ribonuclease H activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLPRYFCWN LQRCTMAFYA VASGRRSGVY GSWAECEEQV KGFKNAKYKK FKTRQEADQF  60
   61 VNGCKSYAPQ DVAVPLGKEK ASLASWKNSI EVNKNPKYTD EWPEEDHDLA EDDLPDILNR 120
  121 KRKGTTSGDK RNKIPRHASQ VSEATGLKQV GAFQFEIDAE GYVIVYTDGS CIGNGRAGAC 180
  181 AGYGVYFGKN HQLNAAKPVE GRVTNNVGEI QAAIHAIKTA LDLGIQKLCI STDSQFLINS 240
  241 ITLWVAGWKK RDWKLKNNQP VKNVVDFKEL DKLLQENNIT VKWNYVEAHK GIEGNEMADK 300
  301 LARQGSALYK QKNG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..314] PSI-BLAST 60.69897 HIV RNase H (Domain of reverse transcriptase); HIV-1 reverse transcriptase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonuclease activity
    		•  4.81599779544001 bayes_pls_golite062009
  • exoribonuclease activity
    		•  3.01417328311605 bayes_pls_golite062009
  • ribonuclease H activity
    		•  2.91966688044755 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  2.89077854960958 bayes_pls_golite062009
  • exonuclease activity
    		•  2.69024175413643 bayes_pls_golite062009
  • nuclease activity
    		•  2.65398446409354 bayes_pls_golite062009
  • endonuclease activity
    		•  2.63074055051349 bayes_pls_golite062009
  • endoribonuclease activity
    		•  2.59247838057313 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.57498413015114 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.49957333962564 bayes_pls_golite062009
  • hydrolase activity
    		•  2.41899414621161 bayes_pls_golite062009
  • DNA polymerase activity
    		•  1.82615627615268 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.68530265026203 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.61250137150057 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • binding
    		•  1.20709976964365 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.12235348738959 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.1219517187744 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10433412699603 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.86862629020506 bayes_pls_golite062009
  • DNA binding
    		•  0.710663468386339 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.708753843279937 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.623018247078448 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.598360955770972 bayes_pls_golite062009
  • transcription factor activity
    		•  0.332903382446869 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.278838342302102 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.261428436029202 bayes_pls_golite062009
  • protein binding
    		•  0.242714557118293 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.68

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle