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View Structure Prediction Details

Protein: rnh1-PB
Organism: Drosophila melanogaster
Length: 314 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rnh1-PB.

Description E-value Query
Range
Subject
Range
POL_HV196 - Gag-Pol polyprotein OS=Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) GN...
255.0 [0..26] [308..878]

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Predicted Domain #1
Region A:
Residues: [1-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLPRYFCWN LQRCTMAFYA VASGRRSGVY GSWAECEEQV KGFKNAKYKK FKTRQEADQF  60
   61 VNGCKSYAPQ DVAVPLGKEK ASLASWKNSI EVNKNPKYTD EWPEEDHDLA EDDLPDILNR 120
  121 KRKGTTSGDK RNKIPRHASQ VSEATGLKQV GAFQFEIDAE GYVIVYTDGS CIGNGRAGAC 180
  181 AGYGVYFGKN HQLNAAKPVE GRVTNNVGEI QAAIHAIKTA LDLGIQKLCI STDSQFLINS 240
  241 ITLWVAGWKK RDWKLKNNQP VKNVVDFKEL DKLLQENNIT VKWNYVEAHK GIEGNEMADK 300
  301 LARQGSALYK QKNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.69897
Match: 1jkhA
Description: HIV RNase H (Domain of reverse transcriptase); HIV-1 reverse transcriptase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease activity 4.81599779544001 bayes_pls_golite062009
exoribonuclease activity 3.01417328311605 bayes_pls_golite062009
ribonuclease H activity 2.91966688044755 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 2.89077854960958 bayes_pls_golite062009
exonuclease activity 2.69024175413643 bayes_pls_golite062009
nuclease activity 2.65398446409354 bayes_pls_golite062009
endonuclease activity 2.63074055051349 bayes_pls_golite062009
endoribonuclease activity 2.59247838057313 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.57498413015114 bayes_pls_golite062009
3'-5'-exoribonuclease activity 2.49957333962564 bayes_pls_golite062009
hydrolase activity 2.41899414621161 bayes_pls_golite062009
DNA polymerase activity 1.82615627615268 bayes_pls_golite062009
DNA-directed DNA polymerase activity 1.68530265026203 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.61250137150057 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
binding 1.20709976964365 bayes_pls_golite062009
nucleic acid binding 1.12235348738959 bayes_pls_golite062009
deoxyribonuclease activity 1.1219517187744 bayes_pls_golite062009
transcription regulator activity 1.10433412699603 bayes_pls_golite062009
3'-5' exonuclease activity 0.86862629020506 bayes_pls_golite062009
DNA binding 0.710663468386339 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
nucleotidyltransferase activity 0.623018247078448 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
transcription factor activity 0.332903382446869 bayes_pls_golite062009
exodeoxyribonuclease activity 0.278838342302102 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.261428436029202 bayes_pls_golite062009
protein binding 0.242714557118293 bayes_pls_golite062009

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