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Protein Overview: Ndg-PB

General Information:
Name(s) found: Ndg-PB / FBpp0087439 [FlyBase]
Description(s) found:
Found 12 descriptions.
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  • The gene Nidogen/entactin is referred to in FlyBase by the symbol Dmel\Ndg (CG12908, FBgn0026403). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6201423..6209405. It has the cytological map location 47A1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: calcium ion binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein-chromophore linkage; bioluminescence; cell-matrix adhesion. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1370 amino acids

    Gene Ontology:
    Cellular Component: basement membrane [ISS]
    membrane [IEA]
    Biological Process: cell-matrix adhesion [IEA]
    protein-chromophore linkage [IEA]
    bioluminescence [IEA]
    Molecular Function: calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTFGSKLLA CLLLSSVILV SGQFEHYLDS LRASELYEFE DGSLGSIHLL PKGDSETIVL  60
   61 QLEQPIHFYG EQYEQLYINT NGILTFNSEF PEYLNQPFPL EYASIAAFYS NVDTSFSDEG 120
  121 TSISLFESKE QSILDRASSL VRYAFSSQSE FEARQVIVAT WRNVGYFDSK TDRLNTFQVA 180
  181 LIANEQSTFV QFIYPDGGLN WLQGETAGLG LPDIRAQAGF VAEDGRFYTL NGSGSENARF 240
  241 LSESTNLGVP GVWLFEVAPI ENEQNVRSPD NAESLTESPA LALSCQAHAH QCHEKAECHD 300
  301 KAEGYCCVCG SGFYGNGKSC LANDQPIRVT GTLTGELNKQ PVSEEAKLQS YVVTSEGRTY 360
  361 TTINPLTPEL GAQLRLVLPL LTTVPWLFAK SVGGVANGYQ LTGGVYTHVS RLQFDSGENL 420
  421 HVNQTFEGLN YWDQLSVKIE IYGEVPAVAA DAVLILPDYV EEYTFERPGE LKSVQVLNIN 480
  481 ITEEQRVLGL QVEQRILYRS CLRDDEADPS ATKVLQKISK VALDYVERDQ ALRIGAMSKV 540
  541 GVTPESNACN DGTADCVENS VCVPYEDTYR CDCYHGFAAQ LDERGVEVCL DIDECATGSH 600
  601 VCDENAVCDN TEGGFNCYCT EGFEGNGYRC LSNSTADNIE YPPAVEGQAE PTSEPSPNPS 660
  661 PYPDQGQDQE REREDDQYPQ PNPYPYPEEQ IPQHPDECYR CSKDADCYQG RCTCHEGFDG 720
  721 DGYTCTNICG HGEVWENGRC EPLLLERHDV DPLCDALGEC RCPYGYELSE DSQRCTYVQE 780
  781 FDGERNADLI PCDVDENCHI NATCNWYGQE LRHICTCQPG FRGDGYNCDP ISDDSCAIVS 840
  841 DYSPIYDIPM TASLKPLQRP DICDVHADCV YEEHLGKSEC QCQAGYTGNG FNCQLAAECQ 900
  901 SAEHCGENAF CDDGVCRCQA DFERDVSDRC VPAGRCGSVF CGSNAICKWD SAEGVQYCDC 960
  961 LDGYQGDALT GCTSKPLSCH VLNNCGIHAT CEPTEDPANY ECQCIAGFKG DGYVCIEEQN1020
 1021 CLNNPTLCDM NAQCRSTNSG LVCVCNQGFF GNGSLCQERQ HQDSDFLIVS QGVMIARVPL1080
 1081 NGRNVRPISV AQMAIGLDKD CVEGRVYWGD ISTKKIVSTK YDGTDLRPFI TTDIESPEGI1140
 1141 AIDVISRRLY WADSAKDTIE VASLDDPSLR AVIINKQLVN PRGIAVDPYR EKLFWSDWDR1200
 1201 ESPKIEMSNL DGTGRELLLG KDDVTLPNSL VVLENSGEVC YADAGTKKVE CIEPQNRQIR1260
 1261 TISNELSYPF GITFTHDQFY WTDWTTKKVE IVDSLGARQT PIQPPFFGSH KMYGMTVVEQ1320
 1321 HCPQYQSPCQ ISNGGCTDSR LCLVNRQAPS GKSCKCTSAS TGCTVLAPGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..146] deduced N/A No confident structure predictions are available.
    2 View Details [147..268] Pfam 18.537602 No description for PF06119.5 was found. No confident structure predictions are available.
    3 View Details [269..544] PSI-BLAST 35.69897 Domain G2 of nidogen-1; EGF-like domain of nidogen-1
    4 View Details [545..681] PSI-BLAST 10.0 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    5 View Details [682..1370] PSI-BLAST 114.0 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • lipoprotein binding
    		•  2.85368924610519 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  2.54260987806255 bayes_pls_golite062009
  • protein binding
    		•  2.53596086569239 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.52206476012132 bayes_pls_golite062009
  • binding
    		•  2.36338045524751 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.95292425479529 bayes_pls_golite062009
  • receptor activity
    		•  1.78685457669149 bayes_pls_golite062009
  • pattern binding
    		•  1.70736389292491 bayes_pls_golite062009
  • heparin binding
    		•  1.62255185635992 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  1.60646803688398 bayes_pls_golite062009
  • receptor binding
    		•  1.58134144073184 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.3592722174781 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.17408158237797 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  0.876048180035911 bayes_pls_golite062009
  • growth factor activity
    		•  0.453414378307559 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.369745969135526 bayes_pls_golite062009
  • signal transducer activity
    		•  0.369745969135526 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.230499048015879 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  0.103819681297094 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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