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View Structure Prediction Details

Protein: Ndg-PB
Organism: Drosophila melanogaster
Length: 1370 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ndg-PB.

Description E-value Query
Range
Subject
Range
Ndg-PA, FBpp0308545 - The gene Nidogen/entactin is referred to in FlyBase by the symbol Dmel\Ndg (CG12908, FBgn0026403). I...
863.0 [0..1] [1370..1]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTFGSKLLA CLLLSSVILV SGQFEHYLDS LRASELYEFE DGSLGSIHLL PKGDSETIVL  60
   61 QLEQPIHFYG EQYEQLYINT NGILTFNSEF PEYLNQPFPL EYASIAAFYS NVDTSFSDEG 120
  121 TSISLFESKE QSILDRASSL VRYAFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [147-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQSEFEARQV IVATWRNVGY FDSKTDRLNT FQVALIANEQ STFVQFIYPD GGLNWLQGET  60
   61 AGLGLPDIRA QAGFVAEDGR FYTLNGSGSE NARFLSESTN LGVPGVWLFE VAPIENEQNV 120
  121 RS

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 18.537602
Match: PF06119.5
Description: No description for PF06119.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [269-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDNAESLTES PALALSCQAH AHQCHEKAEC HDKAEGYCCV CGSGFYGNGK SCLANDQPIR  60
   61 VTGTLTGELN KQPVSEEAKL QSYVVTSEGR TYTTINPLTP ELGAQLRLVL PLLTTVPWLF 120
  121 AKSVGGVANG YQLTGGVYTH VSRLQFDSGE NLHVNQTFEG LNYWDQLSVK IEIYGEVPAV 180
  181 AADAVLILPD YVEEYTFERP GELKSVQVLN INITEEQRVL GLQVEQRILY RSCLRDDEAD 240
  241 PSATKVLQKI SKVALDYVER DQALRIGAMS KVGVTP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 1gl4A
Description: Domain G2 of nidogen-1; EGF-like domain of nidogen-1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [545-681]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESNACNDGTA DCVENSVCVP YEDTYRCDCY HGFAAQLDER GVEVCLDIDE CATGSHVCDE  60
   61 NAVCDNTEGG FNCYCTEGFE GNGYRCLSNS TADNIEYPPA VEGQAEPTSE PSPNPSPYPD 120
  121 QGQDQERERE DDQYPQP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.0
Match: 1jv2B
Description: Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [682-1370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPYPYPEEQI PQHPDECYRC SKDADCYQGR CTCHEGFDGD GYTCTNICGH GEVWENGRCE  60
   61 PLLLERHDVD PLCDALGECR CPYGYELSED SQRCTYVQEF DGERNADLIP CDVDENCHIN 120
  121 ATCNWYGQEL RHICTCQPGF RGDGYNCDPI SDDSCAIVSD YSPIYDIPMT ASLKPLQRPD 180
  181 ICDVHADCVY EEHLGKSECQ CQAGYTGNGF NCQLAAECQS AEHCGENAFC DDGVCRCQAD 240
  241 FERDVSDRCV PAGRCGSVFC GSNAICKWDS AEGVQYCDCL DGYQGDALTG CTSKPLSCHV 300
  301 LNNCGIHATC EPTEDPANYE CQCIAGFKGD GYVCIEEQNC LNNPTLCDMN AQCRSTNSGL 360
  361 VCVCNQGFFG NGSLCQERQH QDSDFLIVSQ GVMIARVPLN GRNVRPISVA QMAIGLDKDC 420
  421 VEGRVYWGDI STKKIVSTKY DGTDLRPFIT TDIESPEGIA IDVISRRLYW ADSAKDTIEV 480
  481 ASLDDPSLRA VIINKQLVNP RGIAVDPYRE KLFWSDWDRE SPKIEMSNLD GTGRELLLGK 540
  541 DDVTLPNSLV VLENSGEVCY ADAGTKKVEC IEPQNRQIRT ISNELSYPFG ITFTHDQFYW 600
  601 TDWTTKKVEI VDSLGARQTP IQPPFFGSHK MYGMTVVEQH CPQYQSPCQI SNGGCTDSRL 660
  661 CLVNRQAPSG KSCKCTSAST GCTVLAPGY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 114.0
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lipoprotein binding 2.85368924610519 bayes_pls_golite062009
low-density lipoprotein binding 2.54260987806255 bayes_pls_golite062009
protein binding 2.53596086569239 bayes_pls_golite062009
glycosaminoglycan binding 2.52206476012132 bayes_pls_golite062009
binding 2.36338045524751 bayes_pls_golite062009
polysaccharide binding 1.95292425479529 bayes_pls_golite062009
receptor activity 1.78685457669149 bayes_pls_golite062009
pattern binding 1.70736389292491 bayes_pls_golite062009
heparin binding 1.62255185635992 bayes_pls_golite062009
extracellular matrix structural constituent 1.60646803688398 bayes_pls_golite062009
receptor binding 1.58134144073184 bayes_pls_golite062009
collagen binding 1.3611207932336 bayes_pls_golite062009
transmembrane receptor activity 1.3592722174781 bayes_pls_golite062009
carbohydrate binding 1.17408158237797 bayes_pls_golite062009
lipoprotein receptor activity 0.876048180035911 bayes_pls_golite062009
growth factor activity 0.453414378307559 bayes_pls_golite062009
molecular transducer activity 0.369745969135526 bayes_pls_golite062009
signal transducer activity 0.369745969135526 bayes_pls_golite062009
extracellular matrix binding 0.3265100728106 bayes_pls_golite062009
glycoprotein binding 0.230499048015879 bayes_pls_golite062009
low-density lipoprotein receptor activity 0.103819681297094 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle