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Protein Overview: Ndg-PA, FBpp0308545

General Information:
Name(s) found: FBpp0308545 [FlyBase]
Ndg-PA / FBpp0087438 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • type=protein; loc=2R:join(6201779..6202009,6203906..6204385,6204481..6205242,6205349..6205972,6206233..6206503,6206567..6206712,6206773..6207182,6207376..6207533,6208078..6208332,6208389..6208563,6208626..6208910,6208974..6209229); ID=FBpp0308545; name=Ndg-PC; parent=FBgn0026403,FBtr0339459; dbxref=FlyBase:FBpp0308545,FlyBase_Annotation_IDs:CG12908-PC; MD5=d120ce1693a0618b464991ddae3512f2; length=1350; release=r5.56; species=Dmel; [FlyBase]
  • The gene Nidogen/entactin is referred to in FlyBase by the symbol Dmel\Ndg (CG12908, FBgn0026403). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6201423..6209405. It has the cytological map location 47A1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: calcium ion binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein-chromophore linkage; bioluminescence; cell-matrix adhesion. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1350 amino acids

    Gene Ontology:
    Cellular Component: basement membrane [ISS]
    membrane [IEA]
    Biological Process: cell-matrix adhesion [IEA]
    protein-chromophore linkage [IEA]
    bioluminescence [IEA]
    Molecular Function: calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTFGSKLLA CLLLSSVILV SGQFEHYLDS LRASELYEFE DGSLGSIHLL PKGDSETIVL  60
   61 QLEQPIHFYG EQYEQLYINT NGILTFNSEF PEYLNQPFPL EYASIAAFYS NVDTSFSDEG 120
  121 TSISLFESKE QSILDRASSL VRYAFSSQSE FEARQVIVAT WRNVGYFDSK TDRLNTFQVA 180
  181 LIANEQSTFV QFIYPDGGLN WLQGETAGLG LPDIRAQAGF VAEDGRFYTL NGSGSENARF 240
  241 LSESTNLGVP GVWLFEVAPI ENEQNVRSPD NAESLTESPA LALSCQAHAH QCHEKAECHD 300
  301 KAEGYCCVCG SGFYGNGKSC LANDQPIRVT GTLTGELNKQ PVSEEAKLQS YVVTSEGRTY 360
  361 TTINPLTPEL GAQLRLVLPL LTTVPWLFAK SVGGVANGYQ LTGGVYTHVS RLQFDSGENL 420
  421 HVNQTFEGLN YWDQLSVKIE IYGEVPAVAA DAVLILPDYV EEYTFERPGE LKSVQVLNIN 480
  481 ITEEQRVLGL QVEQRILYRS CLRDDEADPS ATKVLQKISK VALDYVERDQ ALRIGAMSKV 540
  541 GVTPESNACN DGTADCVENS VCVPYEDTYR CDCYHGFAAQ LDERGVEVCL DIDECATGSH 600
  601 VCDENAVCDN TEGGFNCYCT EGFEGNGYRC LSNSTADNIE YPPAVEGQAE PTSEPSPNPS 660
  661 PYPDQGQDQE REREDDQYPQ PNPYPYPEEQ IPQHPDECYR CSKDADCYQG RCTCHEGFDG 720
  721 DGYTCTNICG HGEVWENGRC EPLLLERHDV DPLCDALGEC RCPYGYELSE DSQRCTYVQE 780
  781 FDGERNADLI PCDVDENCHI NATCNWYGQE LRHICTCQPG FRGDGYNCDP ISDDSCAIRP 840
  841 DICDVHADCV YEEHLGKSEC QCQAGYTGNG FNCQLAAECQ SAEHCGENAF CDDGVCRCQA 900
  901 DFERDVSDRC VPAGRCGSVF CGSNAICKWD SAEGVQYCDC LDGYQGDALT GCTSKPLSCH 960
  961 VLNNCGIHAT CEPTEDPANY ECQCIAGFKG DGYVCIEEQN CLNNPTLCDM NAQCRSTNSG1020
 1021 LVCVCNQGFF GNGSLCQERQ HQDSDFLIVS QGVMIARVPL NGRNVRPISV AQMAIGLDKD1080
 1081 CVEGRVYWGD ISTKKIVSTK YDGTDLRPFI TTDIESPEGI AIDVISRRLY WADSAKDTIE1140
 1141 VASLDDPSLR AVIINKQLVN PRGIAVDPYR EKLFWSDWDR ESPKIEMSNL DGTGRELLLG1200
 1201 KDDVTLPNSL VVLENSGEVC YADAGTKKVE CIEPQNRQIR TISNELSYPF GITFTHDQFY1260
 1261 WTDWTTKKVE IVDSLGARQT PIQPPFFGSH KMYGMTVVEQ HCPQYQSPCQ ISNGGCTDSR1320
 1321 LCLVNRQAPS GKSCKCTSAS TGCTVLAPGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..146] deduced N/A No confident structure predictions are available.
    2 View Details [147..267] Pfam 18.537602 No description for PF06119.5 was found. No confident structure predictions are available.
    3 View Details [268..543] PSI-BLAST 35.0 Domain G2 of nidogen-1; EGF-like domain of nidogen-1
    4 View Details [544..638] PSI-BLAST 4.69897 Strucuture of the C-terminal domain of human thrombospondin-2
    5 View Details [639..1350] PSI-BLAST 117.0 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • receptor binding
    		•  4.18507256704458 bayes_pls_golite062009
  • lipoprotein binding
    		•  2.85368924610519 bayes_pls_golite062009
  • growth factor activity
    		•  2.65714307626854 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  2.54260987806255 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.52206476012132 bayes_pls_golite062009
  • protein binding
    		•  2.39474188157708 bayes_pls_golite062009
  • binding
    		•  2.23348590722752 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.95292425479529 bayes_pls_golite062009
  • receptor activity
    		•  1.78685457669149 bayes_pls_golite062009
  • pattern binding
    		•  1.70736389292491 bayes_pls_golite062009
  • heparin binding
    		•  1.62255185635992 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  1.60646803688398 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.3592722174781 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.27162188822674 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.17408158237797 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  0.876048180035911 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.230499048015879 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  0.103819681297094 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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