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View Structure Prediction Details

Protein: Ndg-PA, FBpp0308545
Organism: Drosophila melanogaster
Length: 1350 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ndg-PA, FBpp0308545.

Description E-value Query
Range
Subject
Range
Ndg-PB - The gene Nidogen/entactin is referred to in FlyBase by the symbol Dmel\Ndg (CG12908, FBgn0026403). I...
873.0 [0..1] [1350..1]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTFGSKLLA CLLLSSVILV SGQFEHYLDS LRASELYEFE DGSLGSIHLL PKGDSETIVL  60
   61 QLEQPIHFYG EQYEQLYINT NGILTFNSEF PEYLNQPFPL EYASIAAFYS NVDTSFSDEG 120
  121 TSISLFESKE QSILDRASSL VRYAFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [147-267]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQSEFEARQV IVATWRNVGY FDSKTDRLNT FQVALIANEQ STFVQFIYPD GGLNWLQGET  60
   61 AGLGLPDIRA QAGFVAEDGR FYTLNGSGSE NARFLSESTN LGVPGVWLFE VAPIENEQNV 120
  121 R

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 18.537602
Match: PF06119.5
Description: No description for PF06119.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [268-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPDNAESLTE SPALALSCQA HAHQCHEKAE CHDKAEGYCC VCGSGFYGNG KSCLANDQPI  60
   61 RVTGTLTGEL NKQPVSEEAK LQSYVVTSEG RTYTTINPLT PELGAQLRLV LPLLTTVPWL 120
  121 FAKSVGGVAN GYQLTGGVYT HVSRLQFDSG ENLHVNQTFE GLNYWDQLSV KIEIYGEVPA 180
  181 VAADAVLILP DYVEEYTFER PGELKSVQVL NINITEEQRV LGLQVEQRIL YRSCLRDDEA 240
  241 DPSATKVLQK ISKVALDYVE RDQALRIGAM SKVGVT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1gl4A
Description: Domain G2 of nidogen-1; EGF-like domain of nidogen-1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [544-638]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PESNACNDGT ADCVENSVCV PYEDTYRCDC YHGFAAQLDE RGVEVCLDID ECATGSHVCD  60
   61 ENAVCDNTEG GFNCYCTEGF EGNGYRCLSN STADN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1yo8A
Description: Strucuture of the C-terminal domain of human thrombospondin-2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [639-1350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEYPPAVEGQ AEPTSEPSPN PSPYPDQGQD QEREREDDQY PQPNPYPYPE EQIPQHPDEC  60
   61 YRCSKDADCY QGRCTCHEGF DGDGYTCTNI CGHGEVWENG RCEPLLLERH DVDPLCDALG 120
  121 ECRCPYGYEL SEDSQRCTYV QEFDGERNAD LIPCDVDENC HINATCNWYG QELRHICTCQ 180
  181 PGFRGDGYNC DPISDDSCAI RPDICDVHAD CVYEEHLGKS ECQCQAGYTG NGFNCQLAAE 240
  241 CQSAEHCGEN AFCDDGVCRC QADFERDVSD RCVPAGRCGS VFCGSNAICK WDSAEGVQYC 300
  301 DCLDGYQGDA LTGCTSKPLS CHVLNNCGIH ATCEPTEDPA NYECQCIAGF KGDGYVCIEE 360
  361 QNCLNNPTLC DMNAQCRSTN SGLVCVCNQG FFGNGSLCQE RQHQDSDFLI VSQGVMIARV 420
  421 PLNGRNVRPI SVAQMAIGLD KDCVEGRVYW GDISTKKIVS TKYDGTDLRP FITTDIESPE 480
  481 GIAIDVISRR LYWADSAKDT IEVASLDDPS LRAVIINKQL VNPRGIAVDP YREKLFWSDW 540
  541 DRESPKIEMS NLDGTGRELL LGKDDVTLPN SLVVLENSGE VCYADAGTKK VECIEPQNRQ 600
  601 IRTISNELSY PFGITFTHDQ FYWTDWTTKK VEIVDSLGAR QTPIQPPFFG SHKMYGMTVV 660
  661 EQHCPQYQSP CQISNGGCTD SRLCLVNRQA PSGKSCKCTS ASTGCTVLAP GY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 117.0
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.18507256704458 bayes_pls_golite062009
lipoprotein binding 2.85368924610519 bayes_pls_golite062009
growth factor activity 2.65714307626854 bayes_pls_golite062009
low-density lipoprotein binding 2.54260987806255 bayes_pls_golite062009
glycosaminoglycan binding 2.52206476012132 bayes_pls_golite062009
protein binding 2.39474188157708 bayes_pls_golite062009
binding 2.23348590722752 bayes_pls_golite062009
polysaccharide binding 1.95292425479529 bayes_pls_golite062009
receptor activity 1.78685457669149 bayes_pls_golite062009
pattern binding 1.70736389292491 bayes_pls_golite062009
heparin binding 1.62255185635992 bayes_pls_golite062009
extracellular matrix structural constituent 1.60646803688398 bayes_pls_golite062009
collagen binding 1.3611207932336 bayes_pls_golite062009
transmembrane receptor activity 1.3592722174781 bayes_pls_golite062009
epidermal growth factor receptor binding 1.27162188822674 bayes_pls_golite062009
carbohydrate binding 1.17408158237797 bayes_pls_golite062009
lipoprotein receptor activity 0.876048180035911 bayes_pls_golite062009
extracellular matrix binding 0.3265100728106 bayes_pls_golite062009
glycoprotein binding 0.230499048015879 bayes_pls_golite062009
low-density lipoprotein receptor activity 0.103819681297094 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle