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Protein Overview: lola-PV

General Information:
Name(s) found: lola-PV / FBpp0088949 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene longitudinals lacking is referred to in FlyBase by the symbol Dmel\lola (CG12052, FBgn0005630). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6369712..6430767. It has the cytological map location 47A11-47A13. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; cell projection organization; cellular component movement; behavior; sensory organ development; organ morphogenesis; immune response; programmed cell death; neuromuscular process; behavioral interaction between organisms; locomotory behavior; regulation of metabolic process. 163 alleles are reported. The phenotypes of these alleles are annotated with 40 unique terms, many of which group under: peripheral nervous system; nervous system; abdominal lateral monoscolopidial chordotonal organ lch1; embryonic neuron; embryonic nervous system; organ system; multi-cell-component structure; adult segment; abdominal longitudinal muscle; ventral longitudinal muscle. It has 26 annotated transcripts and 26 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 549 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: regulation of gene-specific transcription [IMP]
    R7 cell development [IMP]
    axon guidance [IGI][IMP][NAS]
    nurse cell apoptosis [IMP]
    brain morphogenesis [IMP]
    R3/R4 cell fate commitment [IMP]
    inter-male aggressive behavior [IMP]
    regulation of transcription from RNA polymerase II promoter [NAS]
    locomotion involved in locomotory behavior [IMP]
    startle response [IMP]
    positive regulation of transcription, DNA-dependent [ISS]
    axonogenesis [IMP]
    axon midline choice point recognition [IGI][IMP]
    antimicrobial humoral response [IMP]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [NAS]
    specific RNA polymerase II transcription factor activity [ISS][NAS]
    transcription activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL  60
   61 LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
  121 GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR 180
  181 KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS 240
  241 STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN 300
  301 VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS 360
  361 SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ 420
  421 GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQDVSTNQ TVVLPHYSIY HYYSNIYYLL 480
  481 SHTTIYEADR TVSVSCPGKL NCLPQRNDLQ ETKSVTVLYT IHFFLYILMI YIFVLCKILP 540
  541 RIVFVWVST

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 30.221849 No description for 2nn2A was found.
    2 View Details [195..312] deduced N/A No confident structure predictions are available.
    3 View Details [313..377] deduced N/A No confident structure predictions are available.
    4 View Details [378..463] deduced N/A No confident structure predictions are available.
    5 View Details [464..549] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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