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Protein Overview: Psi-PA

General Information:
Name(s) found: Psi-PA / FBpp0086221 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene P-element somatic inhibitor is referred to in FlyBase by the symbol Dmel\Psi (CG8912, FBgn0014870). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12750470..12755218. It has the cytological map location 53D14. There is experimental evidence that it has the molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: mRNA processing; negative regulation of nuclear mRNA splicing, via spliceosome; regulation of nuclear mRNA splicing, via spliceosome; regulation of alternative nuclear mRNA splicing, via spliceosome; spermatogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: onion stage spermatid; spermatid; testis. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 716 amino acids

    Gene Ontology:
    Cellular Component: U1 snRNP [IPI]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    negative regulation of nuclear mRNA splicing, via spliceosome [IDA][IMP]
    spermatogenesis [IMP]
    regulation of nuclear mRNA splicing, via spliceosome [IMP]
    mRNA processing [IDA]
    Molecular Function: mRNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGSGGGGG GGGGPGGASI TQAIAQAAAV AARLAASAGT SCEEQIRLPE SVAGAFMGRS  60
   61 SNDTITHIQA ESGVKVQVMQ DQDRVIMLRG QRDTVTKGRE MIQNMANRAG GGQVEVLLTI 120
  121 NMPPPGPSGY PPYQEIMIPG AKVGLVIGKG GDTIKQLQEK TGAKMIIIQD GPNQELIKPL 180
  181 RISGEAQKIE HAKQMVLDLI AQKDAQGQQQ GGRGGGGGGG GPGMGFNNFN NGNGGESTEV 240
  241 FVPKIAVGVV IGKGGDMIRK IQTECGCKLQ FIQGKNDEMG DRRCVIQGTR QQVDDAKRTI 300
  301 DGLIENVMQR NGMNRNGNGG GGGPGGDSGN SNYGYGYGVN HAQGGREEIT FLVPASKCGI 360
  361 VIGRGGETIK LINQQSGAHT EMDRNASNPP NEKLFKSKGT TDQVEAARQM ISEKINMELN 420
  421 VISRKPIGGG PGGGGGNSGG GQNNSHHNQQ QGGYGGQNQM QGGDPNSGAG YQQQPWGGPY 480
  481 GQQGWDPSGQ QQQMAMANQG GSAAGGASGG QDYSAQWIEY YKQMGCHREA EMIEQQMKAK 540
  541 QAGGSSGPVQ QQQPQQQQQS QQQTGGAGAG GADYSAQWAE YYRSVGKIEE AEAIEKTLKN 600
  601 KQNGSGGQSS TPNPSQGGSG QQQPNPAAAA AAAAAAAAAA GGYGQSMTPT QYAQYSQYYA 660
  661 AAAAAGGQPQ GAPQPGGGQS GGPPGNYPGN YPGAGYGGYP GAPGQQQQKS HKNDNH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] PSI-BLAST 13.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    2 View Details [121..321] PSI-BLAST 28.0 No description for 2annA was found.
    3 View Details [322..424] PSI-BLAST 20.522879 Far upstream binding element, FBP, KH3 and KH4 domains
    4 View Details [425..607] deduced N/A No confident structure predictions are available.
    5 View Details [608..716] PSI-BLAST 6.522879 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  0.766407798661875 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.1608635436815 bayes_pls_golite062009
  • RNA binding
    		•  0.0205643208063799 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle