Protein Overview: par-1-PH

General Information:
Name(s) found:	par-1-PH / FBpp0085653 [FlyBase]
Description(s) found: Found 36 descriptions. SHOW ALL	The gene par-1 is referred to in FlyBase by the symbol Dmel\par-1 (CG8201, FBgn0260934). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15343679..15371978. It has the cytological map location 56D9-57D12. There is experimental evidence that it has the molecular function</span>: tau-protein kinase activity; protein kinase activity. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; organelle organization; ovarian follicle cell development; regulation of developmental process; multicellular organism reproduction; regulation of cell morphogenesis; oocyte axis specification; regulation of cellular component organization; microtubule cytoskeleton organization; immune response; actin filament-based process; delamination. 59 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; external compound sense organ; peripheral nervous system; female germline cyst; cuticle; abdominal ventral denticle belt; nervous system; compound cell cluster organ; blastoderm embryo; abdominal 5 ventral denticle belt; embryonic segment. It has 19 annotated transcripts and 19 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	993 amino acids
Gene Ontology:
Cellular Component:	germline ring canal [IDA] cell cortex [IDA] fusome [IDA] basolateral plasma membrane [IDA]
Biological Process:	regulation of cell shape [IMP] germarium-derived oocyte fate determination [IMP][TAS] axis specification [IMP] border follicle cell delamination [IMP] actin filament organization [IMP] gamete generation [IMP] border follicle cell migration [IMP] oocyte differentiation [TAS] microtubule cytoskeleton organization [IMP] protein amino acid phosphorylation [ISS][NAS] oocyte anterior/posterior axis specification [TAS] anterior/posterior axis specification [TAS] maintenance of protein location [TAS] regulation of pole plasm oskar mRNA localization [IMP] pole plasm protein localization [IMP] oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [IMP] ovarian follicle cell development [IMP] pole plasm oskar mRNA localization [TAS] regulation of Wnt receptor signaling pathway [TAS] antimicrobial humoral response [IMP] oocyte microtubule cytoskeleton organization [IMP][TAS]
Molecular Function:	tau-protein kinase activity [IDA] ATP binding [IEA] protein kinase activity [IDA] protein serine/threonine kinase activity [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQTSSHRQM HHSSNNNNKE EPPQPASQFG NRRTSTRKST SSSKHYPTLV QPLRKDELSL  60
   61 LRDSLLRNGS IMRKNPERRP VTISELKPVN TGQGTSGSVL PITAEDAAGG SSSSITQLMA 120
  121 FQLPVDRSAK TDDLAAESSA SAAAAVAPKE GRNEFYIVGD GYHRTDHCYY RSPNGDFHKL 180
  181 PSDSFHKMSE GCFVRMADGV FRRLEVPTKA QISRRSSRAE EIGDATSQGN GSAATNVKSQ 240
  241 LMRFLKRSKS HTPATIAKLQ REKEEARAER KQRLSNALRQ KNLAATNAAS AAAANSSYAS 300
  301 GGGGGTVSSR NNKIVVTMIE NGGLPIVATS KAERPKAKES ASSSDKARNS RGSPNMQMRS 360
  361 SAPMRWRATE EHIGKYKLIK TIGKGNFAKV KLAKHLPTGK EVAIKIIDKT QLNPGSLQKL 420
  421 FREVRIMKML DHPNIVKLFQ VIETEKTLYL IMEYASGGEV FDYLVLHGRM KEKEARVKFR 480
  481 QIVSAVQYCH QKRIIHRDLK AENLLLDSEL NIKIADFGFS NEFTPGSKLD TFCGSPPYAA 540
  541 PELFQGKKYD GPEVDVWSLG VILYTLVSGS LPFDGSTLRE LRERVLRGKY RIPFYMSTDC 600
  601 ENLLRKFLVL NPAKRASLET IMGDKWMNMG FEEDELKPYI EPKADLADPK RIEALVAMGY 660
  661 NRSEIEASLS QVRYDDVFAT YLLLGRKSTD PESDGSRSGS SLSLRNISGN DAGANAGSAS 720
  721 VQSPTHRGVH RSISASSTKP SRRASSGAET LRVGPTNAAA TVAAATGAVG AVNPSNNYNA 780
  781 AGSAADRASV GSNFKRQNTI DSATIKENTA RLAAQNQRPA SATQKMLTTA DTTLNSPAKP 840
  841 RTATKYDPTN GNRTVSGTSG IIPRRSTTLY EKTSSTEKTN VIPAETNSGS AAPAGKGHTK 900
  901 SASVSSPRPS TDGCVSVSND PLGTRMASAV KSSRHFPRNV PSRSTFHSGQ TRARNNTALE 960
  961 YSGTSGASGD SSHPGRMSFF SKLSSRFSKR PNQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
protein kinase activity	5.4586557943719	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	5.04467222534257	bayes_pls_golite062009
kinase activity	4.85903980916957	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.63692708178478	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.26787750561728	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
molecular adaptor activity	1.33740973673697	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.2323381312171	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
cytoskeletal protein binding	1.22172815474021	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
tubulin binding	0.525721160726465	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
actin binding	0.456340967230669	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
microtubule binding	0.191960933574742	bayes_pls_golite062009
MAP kinase activity	0.08504542461349	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.0556163711947139	bayes_pls_golite062009
transmembrane receptor activity	0.00652065412910241	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..109]	deduced	N/A	No confident structure predictions are available.
2	View Details	[110..637]	PSI-BLAST	59.221849	No description for 2h8hA was found.
3	View Details	[638..729]	PSI-BLAST	100.0	No description for 2qnjA was found.
4	View Details	[730..904]	deduced	N/A	No confident structure predictions are available.
5	View Details	[905..993]	deduced	N/A	No confident structure predictions are available.

Protein Overview: par-1-PH

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: