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Protein Overview: gro-PE

General Information:
Name(s) found: gro-PE / FBpp0089115 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene groucho is referred to in FlyBase by the symbol Dmel\gro (CG8384, FBgn0001139). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21867432..21875634. It has the cytological map location 96F10. There is experimental evidence that it has the molecular function</span>: protein binding; transcription corepressor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription; dendrite morphogenesis; nervous system development; negative regulation of transcription from RNA polymerase II promoter; actin filament organization. 113 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system; adult segment; peripheral nervous system; adult mesothoracic segment; nervous system; thoracic segment; external compound sense organ; cell projection; embryonic nervous system; neuron projection. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 730 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS][TAS]
    protein complex [IPI]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IPI][TAS]
    negative regulation of transcription [IGI][NAS][TAS]
    nervous system development [IMP][NAS]
    actin filament organization [IMP]
    negative regulation of Wnt receptor signaling pathway [NAS]
    sex determination, primary response to X:A ratio [TAS]
    regulation of transcription [IEA]
    dendrite morphogenesis [IMP]
    Molecular Function: [NOT]DNA binding [NAS]
    protein binding [IPI]
    transcription corepressor activity [IPI][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYPSPVRHPA AGGPPPQGPI KFTIADTLER IKEEFNFLQA QYHSIKLECE KLSNEKTEMQ  60
   61 RHYVMYYEMS YGLNVEMHKQ TEIAKRLNTL INQLLPFLQA DHQQQVLQAV ERAKQVTMQE 120
  121 LNLIIGHQQQ HGIQQLLQQI HAQQVPGGPP QPMGALNPFG ALGATMGLPH GPQGLLNKPP 180
  181 EHHRPDIKPT GLEGPAAAEE RLRNSVSPAD REKYRTRSPL DIENDSKRRK DEKLQEDEGE 240
  241 KSDQDLVVDV ANEMESHSPR PNGEHVSMEV RDRESLNGER LEKPSSSGIK QERPPSRSGS 300
  301 SSSRSTPSLK TKDMEKPGTP GAKARTPTPN AAAPAPGVNP KQMMPQGPPP AGYPGAPYQR 360
  361 PADPYQRPPS DPAYGRPPPM PYDPHAHVRT NGIPHPSALT GGKPAYSFHM NGEGSLQPVP 420
  421 FPPDALVGVG IPRHARQINT LSHGEVVCAV TISNPTKYVY TGGKGCVKVW DISQPGNKNP 480
  481 VSQLDCLQRD NYIRSVKLLP DGRTLIVGGE ASNLSIWDLA SPTPRIKAEL TSAAPACYAL 540
  541 AISPDSKVCF SCCSDGNIAV WDLHNEILVR QFQGHTDGAS CIDISPDGSR LWTGGLDNTV 600
  601 RSWDLREGRQ LQQHDFSSQI FSLGYCPTGD WLAVGMENSH VEVLHASKPD KYQLHLHESC 660
  661 VLSLRFAACG KWFVSTGKDN LLNAWRTPYG ASIFQSKETS SVLSCDISTD DKYIVTGSGD 720
  721 KKATVYEVIY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] Pfam 89.481486 No description for PF03920.6 was found. No confident structure predictions are available.
    2 View Details [145..646] PSI-BLAST 43.0 Actin interacting protein 1
    3 View Details [647..730] PSI-BLAST 81.522879 Groucho/tle1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • GTPase activity
    		•  2.60028864890135 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.39923391651476 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.900963766598159 bayes_pls_golite062009
  • actin binding
    		•  0.708446291495757 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • receptor binding
    		•  0.316169754698691 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
    		• 0.0430091774124504 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle