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Protein Overview: wfs1-PB

General Information:
Name(s) found: wfs1-PB / FBpp0083728 [FlyBase]
Description(s) found:
Found 12 descriptions.
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  • The gene wolfram syndrome 1 is referred to in FlyBase by the symbol Dmel\wfs1 (CG4917, FBgn0039003). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18513264..18516055. It has the cytological map location 94C1. Based on sequence similarity, it is predicted to have molecular function</span>: glutamate-cysteine ligase activity. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 872 amino acids

    Gene Ontology:
    Cellular Component: glutamate-cysteine ligase complex [ISS]
    Biological Process: NONE FOUND
    Molecular Function: glutamate-cysteine ligase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATWTQNEPT GVTKRRRWNL EDRASLNKLK HHIAEEGCPQ MQYDLAKELL DNSIGECKDL  60
   61 LENYKIMKIA MSAVEPNLAK GNQSQKAVNW LVSAAHNGHE DAVKLLRQCY NDGSGITAEN 120
  121 TDEVRRCLAM TPGERAARKA ARELFACLSN GNEHITPKQL ERKMRRIYNL QRKRRRRDDD 180
  181 RSSSSSEGEQ EPECEPLEDV PTIDLANVER RRLITEAHLV SAASNYSAGQ MPSVNDALTL 240
  241 SVPDPRSLDH VPCFYRMIFH PLIFFTLFYH RLLNLIVSIP NVIPLSVRCS VLVAISWWSS 300
  301 RHMLPLVSYY LSLGIMIWAT CKMLKTKQQF VDFRIWSGLF LSYGDQNIEA DIAEHRFLRN 360
  361 NMKPYLYFFC AFICNLIVYP LVTDAWLPHS ELTIISGALT FITMCVSMYA SSHQLPDWLV 420
  421 IVSFAVNVLA KYPYEMDEVV STRWRFLDLR VPTFSSFVIG NGIEFCLNCR TALYLFIPVL 480
  481 LIMMAKRSRW HGVYTFLIPH CVTLSWLQVC IATSQSSTVF GVMRAALGLA GIVLFLPLFG 540
  541 IVALLVPVFV AIDSLGLASE QLRWGSTALA CGLVVVLSCI LALNRATQKY ITMLQLITAI 600
  601 TTACLLVLPY MTSSFKDTPR FNAMPRAGLH SLSETNTLPW DRFHALCAQP VHEQPNKIKA 660
  661 QLRCSLLNGM PVIWEGSVTK VEISRVSNFL EDTIANYLPV WLGRMLRCLH GENISQHFKC 720
  721 DPKLDAQCEE WRSVFKTFNA QSGSCTLQRW NRYEYELLVK VGTKRSGRLL GRSTTTDVIL 780
  781 RAHHDFGNFT RLLSEGDVVL FYGILHNSRL LADNVQVKLK TIECVECRSR DLGTASIERV 840
  841 VAASPMDARL QDLMRGIKYL LNALLNPLIT FK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] FFAS03 2.09 Cysteine rich protein B (HcpB)
    2 View Details [177..400] deduced N/A No confident structure predictions are available.
    3 View Details [401..634] deduced N/A No confident structure predictions are available.
    4 View Details [635..714] deduced N/A No confident structure predictions are available.
    5 View Details [715..872] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.5440224443384 bayes_pls_golite062009
  • protein binding
    		•  0.552010800232555 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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