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View Structure Prediction Details

Protein: wfs1-PB
Organism: Drosophila melanogaster
Length: 872 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for wfs1-PB.

Description E-value Query
Range
Subject
Range
wfs1-PA - The gene wolfram syndrome 1 is referred to in FlyBase by the symbol Dmel\wfs1 (CG4917, FBgn0039003)....
1325.0 [0..1] [872..1]

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Predicted Domain #1
Region A:
Residues: [1-176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATWTQNEPT GVTKRRRWNL EDRASLNKLK HHIAEEGCPQ MQYDLAKELL DNSIGECKDL  60
   61 LENYKIMKIA MSAVEPNLAK GNQSQKAVNW LVSAAHNGHE DAVKLLRQCY NDGSGITAEN 120
  121 TDEVRRCLAM TPGERAARKA ARELFACLSN GNEHITPKQL ERKMRRIYNL QRKRRR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.09
Match: 1klxA
Description: Cysteine rich protein B (HcpB)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.5440224443384 bayes_pls_golite062009
protein binding 0.552010800232555 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [177-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDDDRSSSSS EGEQEPECEP LEDVPTIDLA NVERRRLITE AHLVSAASNY SAGQMPSVND  60
   61 ALTLSVPDPR SLDHVPCFYR MIFHPLIFFT LFYHRLLNLI VSIPNVIPLS VRCSVLVAIS 120
  121 WWSSRHMLPL VSYYLSLGIM IWATCKMLKT KQQFVDFRIW SGLFLSYGDQ NIEADIAEHR 180
  181 FLRNNMKPYL YFFCAFICNL IVYPLVTDAW LPHSELTIIS GALT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [401-634]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FITMCVSMYA SSHQLPDWLV IVSFAVNVLA KYPYEMDEVV STRWRFLDLR VPTFSSFVIG  60
   61 NGIEFCLNCR TALYLFIPVL LIMMAKRSRW HGVYTFLIPH CVTLSWLQVC IATSQSSTVF 120
  121 GVMRAALGLA GIVLFLPLFG IVALLVPVFV AIDSLGLASE QLRWGSTALA CGLVVVLSCI 180
  181 LALNRATQKY ITMLQLITAI TTACLLVLPY MTSSFKDTPR FNAMPRAGLH SLSE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [635-714]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNTLPWDRFH ALCAQPVHEQ PNKIKAQLRC SLLNGMPVIW EGSVTKVEIS RVSNFLEDTI  60
   61 ANYLPVWLGR MLRCLHGENI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [715-872]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQHFKCDPKL DAQCEEWRSV FKTFNAQSGS CTLQRWNRYE YELLVKVGTK RSGRLLGRST  60
   61 TTDVILRAHH DFGNFTRLLS EGDVVLFYGI LHNSRLLADN VQVKLKTIEC VECRSRDLGT 120
  121 ASIERVVAAS PMDARLQDLM RGIKYLLNAL LNPLITFK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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