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Protein Overview: wfs1-PA

General Information:
Name(s) found: wfs1-PA / FBpp0083727 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene wolfram syndrome 1 is referred to in FlyBase by the symbol Dmel\wfs1 (CG4917, FBgn0039003). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18513264..18516055. It has the cytological map location 94C1. Based on sequence similarity, it is predicted to have molecular function</span>: glutamate-cysteine ligase activity. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 853 amino acids

    Gene Ontology:
    Cellular Component: glutamate-cysteine ligase complex [ISS]
    Biological Process: NONE FOUND
    Molecular Function: glutamate-cysteine ligase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATWTQNEPT GVTKRRRWNL EDRASLNKLK HHIAEEGCPQ MQYDLAKELL DNSIVEPNLA  60
   61 KGNQSQKAVN WLVSAAHNGH EDAVKLLRQC YNDGSGITAE NTDEVRRCLA MTPGERAARK 120
  121 AARELFACLS NGNEHITPKQ LERKMRRIYN LQRKRRRRDD DRSSSSSEGE QEPECEPLED 180
  181 VPTIDLANVE RRRLITEAHL VSAASNYSAG QMPSVNDALT LSVPDPRSLD HVPCFYRMIF 240
  241 HPLIFFTLFY HRLLNLIVSI PNVIPLSVRC SVLVAISWWS SRHMLPLVSY YLSLGIMIWA 300
  301 TCKMLKTKQQ FVDFRIWSGL FLSYGDQNIE ADIAEHRFLR NNMKPYLYFF CAFICNLIVY 360
  361 PLVTDAWLPH SELTIISGAL TFITMCVSMY ASSHQLPDWL VIVSFAVNVL AKYPYEMDEV 420
  421 VSTRWRFLDL RVPTFSSFVI GNGIEFCLNC RTALYLFIPV LLIMMAKRSR WHGVYTFLIP 480
  481 HCVTLSWLQV CIATSQSSTV FGVMRAALGL AGIVLFLPLF GIVALLVPVF VAIDSLGLAS 540
  541 EQLRWGSTAL ACGLVVVLSC ILALNRATQK YITMLQLITA ITTACLLVLP YMTSSFKDTP 600
  601 RFNAMPRAGL HSLSETNTLP WDRFHALCAQ PVHEQPNKIK AQLRCSLLNG MPVIWEGSVT 660
  661 KVEISRVSNF LEDTIANYLP VWLGRMLRCL HGENISQHFK CDPKLDAQCE EWRSVFKTFN 720
  721 AQSGSCTLQR WNRYEYELLV KVGTKRSGRL LGRSTTTDVI LRAHHDFGNF TRLLSEGDVV 780
  781 LFYGILHNSR LLADNVQVKL KTIECVECRS RDLGTASIER VVAASPMDAR LQDLMRGIKY 840
  841 LLNALLNPLI TFK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..231] PSI-BLAST 41.522879 Helicobacter cysteine rich protein C (HcpC)
    2 View Details [232..410] deduced N/A No confident structure predictions are available.
    3 View Details [411..615] deduced N/A No confident structure predictions are available.
    4 View Details [616..695] deduced N/A No confident structure predictions are available.
    5 View Details [696..751] deduced N/A No confident structure predictions are available.
    6 View Details [752..853] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.54024956659061 bayes_pls_golite062009
  • protein binding
    		•  0.559882636047776 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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