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View Structure Prediction Details

Protein: wfs1-PA
Organism: Drosophila melanogaster
Length: 853 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for wfs1-PA.

Description E-value Query
Range
Subject
Range
wfs1-PB - The gene wolfram syndrome 1 is referred to in FlyBase by the symbol Dmel\wfs1 (CG4917, FBgn0039003)....
1056.0 [0..1] [853..1]

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Predicted Domain #1
Region A:
Residues: [1-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATWTQNEPT GVTKRRRWNL EDRASLNKLK HHIAEEGCPQ MQYDLAKELL DNSIVEPNLA  60
   61 KGNQSQKAVN WLVSAAHNGH EDAVKLLRQC YNDGSGITAE NTDEVRRCLA MTPGERAARK 120
  121 AARELFACLS NGNEHITPKQ LERKMRRIYN LQRKRRRRDD DRSSSSSEGE QEPECEPLED 180
  181 VPTIDLANVE RRRLITEAHL VSAASNYSAG QMPSVNDALT LSVPDPRSLD H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.522879
Match: 1ouvA
Description: Helicobacter cysteine rich protein C (HcpC)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.54024956659061 bayes_pls_golite062009
protein binding 0.559882636047776 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [232-410]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPCFYRMIFH PLIFFTLFYH RLLNLIVSIP NVIPLSVRCS VLVAISWWSS RHMLPLVSYY  60
   61 LSLGIMIWAT CKMLKTKQQF VDFRIWSGLF LSYGDQNIEA DIAEHRFLRN NMKPYLYFFC 120
  121 AFICNLIVYP LVTDAWLPHS ELTIISGALT FITMCVSMYA SSHQLPDWLV IVSFAVNVL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [411-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKYPYEMDEV VSTRWRFLDL RVPTFSSFVI GNGIEFCLNC RTALYLFIPV LLIMMAKRSR  60
   61 WHGVYTFLIP HCVTLSWLQV CIATSQSSTV FGVMRAALGL AGIVLFLPLF GIVALLVPVF 120
  121 VAIDSLGLAS EQLRWGSTAL ACGLVVVLSC ILALNRATQK YITMLQLITA ITTACLLVLP 180
  181 YMTSSFKDTP RFNAMPRAGL HSLSE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [616-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNTLPWDRFH ALCAQPVHEQ PNKIKAQLRC SLLNGMPVIW EGSVTKVEIS RVSNFLEDTI  60
   61 ANYLPVWLGR MLRCLHGENI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [696-751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQHFKCDPKL DAQCEEWRSV FKTFNAQSGS CTLQRWNRYE YELLVKVGTK RSGRLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [752-853]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRSTTTDVIL RAHHDFGNFT RLLSEGDVVL FYGILHNSRL LADNVQVKLK TIECVECRSR  60
   61 DLGTASIERV VAASPMDARL QDLMRGIKYL LNALLNPLIT FK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle