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Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: glutamate-cysteine ligase activity
Acc: GO:0004357
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.
Synonyms:
  • gamma-glutamylcysteinyl synthetase activity
  • gamma-glutamylcysteine synthetase activity
  • gamma-glutamyl-L-cysteine synthetase activity
  • L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
Proteins in PDR annotated with:
   This term: 22 [Search]
   Term or descendants: 22 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004357 - glutamate-cysteine ligase activity (interactive image map)
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