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Protein Overview: loco-PA

General Information:
Name(s) found: loco-PA / FBpp0083667 [FlyBase]
Description(s) found:
Found 13 descriptions.
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  • The gene locomotion defects is referred to in FlyBase by the symbol Dmel\loco (CG5248, FBgn0020278). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18445690..18465082. It has the cytological map location 94B6-94B8. There is experimental evidence that it has the molecular function</span>: G-protein alpha-subunit binding; GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of G-protein coupled receptor protein signaling pathway; glial cell differentiation; asymmetric neuroblast division; asymmetric protein localization; dorsal/ventral axis specification, ovarian follicular epithelium; establishment of glial blood-brain barrier; cytoplasmic transport, nurse cell to oocyte; cortical actin cytoskeleton organization; septate junction assembly; ventral cord development. 34 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; yolk; embryonic head; embryonic glial cell; neuroblast; embryonic midgut; egg; longitudinal connective; embryonic foregut; dorsal appendage. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1008 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    apical cortex [IDA]
    plasma membrane [IDA]
    Biological Process: cortical actin cytoskeleton organization [IMP]
    ventral cord development [IMP]
    septate junction assembly [IMP]
    dorsal/ventral axis specification, ovarian follicular epithelium [IMP]
    asymmetric neuroblast division [IMP]
    establishment of glial blood-brain barrier [IMP]
    regulation of G-protein coupled receptor protein signaling pathway [IGI][NAS]
    glial cell differentiation [IMP]
    cytoplasmic transport, nurse cell to oocyte [IMP]
    asymmetric protein localization [IMP]
    Molecular Function: G-protein alpha-subunit binding [IPI]
    GTPase activator activity [IDA]
    receptor signaling protein activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPDHSALLRS PPASSSLRRP NLLASFNLIQ SPATNLTSTR SCDDVLNLFV DDSPRTLAAV  60
   61 ASMDDISLHS AAPSLDEGHT FAHPACVPRK MRRSLALETP TTPHKLSAQV FGQPGSRHSL 120
  121 GFEAIDSVQS SVSGACMDQT MDTWASLQNL HKSHKDRTSM SASSSSHCLL EATNSEPDLG 180
  181 NRALPANASP FRRAWGQSSF RTPRSDKVAK EQQQLGQSSP VRRTASMNAS DNDMYIKTLM 240
  241 LDSDLKSSRS QHQLSLLQVP KVLTTPAPPS AITASVAAEG AAQDHGCPSS WAGSFERMLQ 300
  301 DAAGMQTFSE FLKKEFSAEN IYFWTACERY RLLESEADRV AQAREIFAKH LANNSSDPVN 360
  361 VDSQARSLTE EKLADAAPDI FAPAQKQIFS LMKFDSYQRF IRSDLYKSCV EAEQKNQPLP 420
  421 YSGLDLDELL KTNFHLGAFS KLKKSASNAE DRRRKSLLPW HRKTRSKSRD RTEIMADMQH 480
  481 ALMPAPPVPQ NAPLTSASLK LVCGQNSLSD LHSSRSSLSS FDAGTATGGQ GASTESVYSL 540
  541 CRVILTDGAT TIVQTRPGET VGELVERLLE KRNLVYPYYD IVFQGSTKSI DVQQPSQILA 600
  601 GKEVVIERRV AFKLDLPDPK VISVKSKPKK QLHEVIRPIL SKYNYKMEQV QVIMRDTQVP 660
  661 IDLNQPVTMA DGQRLRIVMV NSDFQVGGGS SMPPKQSKPM KPLPQGHLDE LTNKVFNELL 720
  721 ASKADAAASE KSRPVDLCSM KSNEAPSETS SLFERMRRQQ RDGGNIPASK LPKLKKKSTS 780
  781 SSQQSEEAAT TQAVADPKKP IIAKLKAGVK LQVTERVAEH QDELLEGLKR AQLARLEDQR 840
  841 GTEINFDLPD FLKNKENLSA AVSKLRKVRA SLSPVSKVPA TPTEIPQPAP RLSITRSQQP 900
  901 VSPMKVDQEP ETDLPAATQD QTEFAKAPPP LPPKPKVLPI KPSNWGVAQP TGNYCNKYSP 960
  961 SKQVPTSPKE ASKPGTFASK IPLDLGRKSL EEAGSRCAYL DEPSSSFV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..225] deduced N/A No confident structure predictions are available.
    2 View Details [226..417] PSI-BLAST 57.0 Regulator of G-protein signalling 4, RGS4
    3 View Details [418..521] deduced N/A No confident structure predictions are available.
    4 View Details [522..615] FFAS03 4.31 THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
    5 View Details [616..700] PSI-BLAST 11.0 Solution structure of the Ras-binding domain of mouse RGS14
    6 View Details [701..797] deduced N/A No confident structure predictions are available.
    7 View Details [798..1008] MSA 9.247997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • GTPase regulator activity
    		•  1.92987277493861 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.90800479999702 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.87534424848905 bayes_pls_golite062009
  • binding
    		•  1.71250041369331 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.62073651679221 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.49796137854909 bayes_pls_golite062009
  • protein binding
    		•  1.34804002381061 bayes_pls_golite062009
  • signal transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.59248827140739 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.28306198153429 bayes_pls_golite062009
  • binding
    		•  2.0688320293797 bayes_pls_golite062009
  • protein binding
    		•  1.72968950672856 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07208466109379 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07208466109379 bayes_pls_golite062009
  • receptor binding
    		•  0.286966350616338 bayes_pls_golite062009
    5
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.3713276381973 bayes_pls_golite062009
  • binding
    		•  2.14676646738549 bayes_pls_golite062009
  • protein binding
    		•  1.86841453215444 bayes_pls_golite062009
  • signal transducer activity
    		•  1.05682194741929 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.05682194741929 bayes_pls_golite062009
  • receptor binding
    		•  0.298046142314417 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

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