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Protein Overview: C15-PA

General Information:
Name(s) found: C15-PA / FBpp0083510 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene C15 is referred to in FlyBase by the symbol Dmel\C15 (CG7937, FBgn0004863). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17325977..17338054. It has the cytological map location 93E3. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process</span>: bristle development; negative regulation of transcription; elongation of arista core; antennal morphogenesis; positive regulation of Notch signaling pathway; leg disc development; imaginal disc-derived leg morphogenesis; positive regulation of transcription. 7 alleles are reported. The phenotypes of these alleles are annotated with: unguis; ocellar bristle; empodium; tarsal segment 5; tarsal segment 4; arista; pulvillus; mesothoracic bristle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 339 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    protein complex [IPI]
    Biological Process: imaginal disc-derived leg morphogenesis [IMP]
    negative regulation of transcription [IMP]
    regulation of transcription, DNA-dependent [IEA][ISS]
    leg disc development [IMP]
    positive regulation of transcription [IMP]
    antennal morphogenesis [IMP]
    bristle development [IMP]
    regulation of transcription [IEA]
    elongation of arista core [IMP]
    positive regulation of Notch signaling pathway [IEP]
    mesodermal cell fate specification [NAS]
    Molecular Function: transcription factor activity [ISS]
    sequence-specific DNA binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSHEEDDHE HENEHGEEVE EQEIHVDVDS DSRMSCGSGS DVDMDGGSCY DESETPLSES  60
   61 LQSEQTRSSS SENLPFSISR LLSKPFETSH HHHNNNNHLL SSSPGSSSNN NNSGEKGEEK 120
  121 ELLQQEDHDL AYKLATSIAN STYGSAAALY SYPHLYPSAA GGHVLRVPPQ RTPLTWALPP 180
  181 LHHAALAHQA VKDRLAAAFP IARRIGHPYQ NRTPPKRKKP RTSFTRIQVA ELEKRFHKQK 240
  241 YLASAERAAL ARGLKMTDAQ VKTWFQNRRT KWRRQTAEER EAERQAANRL MLSLQAEAIS 300
  301 KGFAPPSAPL GSQGGVNGAP LAALHGLQPW AEASHAAGC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] MSA 5.897996 View MSA. No confident structure predictions are available.
    2 View Details [177..339] PSI-BLAST 27.09691 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle