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Protein Overview: Pk92B-PB

General Information:
Name(s) found: Pk92B-PB / FBpp0089256 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene Protein kinase at 92B is referred to in FlyBase by the symbol Dmel\Pk92B (CG4720, FBgn0014006). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15705441..15711758. It has the cytological map location 92B4. Based on sequence similarity, it is predicted to have molecular function</span>: MAP/ERK kinase kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1196 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of cell shape [IMP]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    programmed cell death [NAS]
    Molecular Function: MAP/ERK kinase kinase activity [ISS]
    ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    protein serine/threonine kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREKFLSDMR TARDTYATNG AKLQSILHEM RKRLDDPHVL SGEVVHSFMC SLRDVQDYDA  60
   61 MVRLVNDLKN IPNTRKYVET GNMSFLYAFA LNRRNRKGDR EKALESSLKA LEKKENHFPD 120
  121 MLCLCGRIYK DIFVESDYTD ATSLAHAIKW YRQSFEVQPN EYAGINLATL LVIEGKEFTN 180
  181 TEELQHIGMT LNNLIGKKGS LSSLSEYWDV ATFFEISVLA NDYAKAIQAA ECMFKLKPPN 240
  241 WYLKSTIGNI SLIHRFRKKP EERQPPIEEQ VFQFWMDFFL EATNTEEVKN SIRFPILILE 300
  301 PQKIYMPSYV TINMDADEKS IQIVNICLAH AKNACKKIHD FLFVASKIKS VSLYKRDDRC 360
  361 AYLYVHHNSD DFQIYFPSTE RRQKFYDMIL EMTADQVVFV NLSNDDANIE YEYDYDEQNR 420
  421 KMVLGKGTYG TVYAARDKQT QVRIAIKEVP EKNSQDVQPL HEEIKLHSQL RHRNIVRYLG 480
  481 SCSENGFFKI FMEQVPGGSL SDLLETKWGP LKDNESTMAF YSKQILEGLK YLHEQDIVHR 540
  541 DIKGDNVLVN TYSGVVKISD FGTSKRLARI NPMTETFTGT LQYMAPEVID QGVRGYGPAA 600
  601 DIWSFGCTNV EMATGKPPFI ELGSAHAAMF KVGFYKKHPN IPEELSANAK NFILRCFAIS 660
  661 VMDRPSASQL LEDPFLQDKP RKVRPALPIN TEFGRSISVP ADRFVHKTTP PLSYNTTCNT 720
  721 PTTPELDITH SSSVDIDELP SNQFMLERRN SHGFLLSPEI EPSTPSLRTS ISETSETDGF 780
  781 YRLKKDSQRR TTLSKVLALD ESKICDIWLK KVDADQNSIA IRKSDLEVLI RGLRDYIMNE 840
  841 NEKHLEATIN ELKQKLNNDA VALDHLHLAL YSFQDAVVCV LRYHCIKPHW MFALDNLVKR 900
  901 AVQAAVTIFS PELGANLADK DLSGNDDESL RTSLMQKGST ESQEKQSLEK VLPTSNTREG 960
  961 VGLTPAESGG DALSSSMECA RILRDIRDNQ QKLQRQLLEQ QRQSMRALHN ISQELAHIYM1020
 1021 GGRKRLRRTI NGFNKKCHRM STSVGGTSGV RPNIAGNPRR QLNKHHFGLH EVDEQLEQWL1080
 1081 TQQEIDEFSK TLILNEGFTF DDFIYNMEKL DLMRLGLRVG IEVRLWKLII QERVCTSSDC1140
 1141 VDSPPSTYHK PIGGNSSFAL IDNNNTLPSP TTTTPGTPGI KTKIKKSESE YDSCSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..178] MSA 1.027931 View MSA. No confident structure predictions are available.
    2 View Details [179..410] PSI-BLAST 5.69897 FERM domain of Focal Adhesion Kinase
    3 View Details [411..679] PSI-BLAST 67.0 No description for 2clqA was found.
    4 View Details [680..1068] PSI-BLAST 10.69897 No description for 2i1jA was found.
    5 View Details [1069..1196] PSI-BLAST 7.0 Tropomyosin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.10982733424055 bayes_pls_golite062009
  • actin binding
    		•  1.78191579080253 bayes_pls_golite062009
  • protein kinase activity
    		•  1.34246406302496 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.07522371528074 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.07023555877478 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.0400654988662 bayes_pls_golite062009
  • kinase activity
    		•  1.02766245357265 bayes_pls_golite062009
  • transporter activity
    		•  0.766644888267526 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.611829373978789 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • transferase activity
    		•  0.351512711954014 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.324566338715835 bayes_pls_golite062009
  • structural molecule activity
    		•  0.320527491838187 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.242570396032937 bayes_pls_golite062009
  • actin filament binding
    		•  0.191274448522781 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.189879136353541 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.18522369054108 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.173125467317897 bayes_pls_golite062009
  • DNA binding
    		•  0.136435190086451 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle